Alata W, Ye Y, St-Amour I, Vandal M, Calon F. Human apolipoprotein E varepsilon4 expression impairs cerebral vascularization and blood–brain barrier function in mice. J Cereb Blood Flow Metab. 2015;35:86–94.
Article
CAS
PubMed
Google Scholar
Altmann A, Tian L, Henderson VW, Greicius MD. Sex modifies the APOE-related risk of developing Alzheimer disease. Ann Neurol. 2014;75:563–73.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ambrose CT. The role of capillaries in the lesser ailments of old age and in Alzheimer's disease and vascular dementia: the potential of Pro-therapeutic angiogenesis. J Alzheimers Dis. 2016;54:31–43.
Article
PubMed
Google Scholar
Bell RD, Winkler EA, Singh I, Sagare AP, Deane R, Wu Z, Holtzman DM, Betsholtz C, Armulik A, Sallstrom J, et al. Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature. 2012;485:512–6.
Article
CAS
PubMed
PubMed Central
Google Scholar
Benedictus MR, Goos JD, Binnewijzend MA, Muller M, Barkhof F, Scheltens P, Prins ND, van der Flier WM. Specific risk factors for microbleeds and white matter hyperintensities in Alzheimer's disease. Neurobiol Aging. 2013;34:2488–94.
Article
CAS
PubMed
Google Scholar
Berlanga-Acosta J, Gavilondo-Cowley J, Lopez-Saura P, Gonzalez-Lopez T, Castro-Santana MD, Lopez-Mola E, Guillen-Nieto G, Herrera-Martinez L. Epidermal growth factor in clinical practice - a review of its biological actions, clinical indications and safety implications. Int Wound J. 2009;6:331–46.
Article
PubMed
Google Scholar
Biron KE, Dickstein DL, Gopaul R, Jefferies WA. Amyloid triggers extensive cerebral angiogenesis causing blood brain barrier permeability and hypervascularity in Alzheimer's disease. PLoS One. 2011;6:e23789.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bjorkqvist M, Ohlsson M, Minthon L, Hansson O. Evaluation of a previously suggested plasma biomarker panel to identify Alzheimer's disease. PLoS One. 2012;7:e29868.
Article
PubMed
PubMed Central
Google Scholar
Boscolo E, Folin M, Nico B, Grandi C, Mangieri D, Longo V, Scienza R, Zampieri P, Conconi MT, Parnigotto PP, et al. Beta amyloid angiogenic activity in vitro and in vivo. Int J Mol Med. 2007;19:581–7.
CAS
PubMed
Google Scholar
Bretsky PM, Buckwalter JG, Seeman TE, Miller CA, Poirier J, Schellenberg GD, Finch CE, Henderson VW. Evidence for an interaction between apolipoprotein E genotype, gender, and Alzheimer disease. Alzheimer Dis Assoc Disord. 1999;13:216–21.
Article
CAS
PubMed
Google Scholar
Burger S, Noack M, Kirazov LP, Kirazov EP, Naydenov CL, Kouznetsova E, Yafai Y, Schliebs R. Vascular endothelial growth factor (VEGF) affects processing of amyloid precursor protein and beta-amyloidogenesis in brain slice cultures derived from transgenic Tg2576 mouse brain. Int J Dev Neurosci. 2009;27:517–23.
Article
PubMed
Google Scholar
Cacciottolo M, Christensen A, Moser A, Liu J, Pike CJ, Smith C, LaDu MJ, Sullivan PM, Morgan TE, Dolzhenko E, et al. The APOE4 allele shows opposite sex bias in microbleeds and Alzheimer's disease of humans and mice. Neurobiol Aging. 2016;37:47–57.
Article
CAS
PubMed
Google Scholar
Cameron DJ, Galvin C, Alkam T, Sidhu H, Ellison J, Luna S, Ethell DW. Alzheimer's-related peptide amyloid-beta plays a conserved role in angiogenesis. PLoS One. 2012;7:e39598.
Article
CAS
PubMed
PubMed Central
Google Scholar
Cantara S, Donnini S, Morbidelli L, Giachetti A, Schulz R, Memo M, Ziche M. Physiological levels of amyloid peptides stimulate the angiogenic response through FGF-2. Faseb j. 2004;18:1943–5.
CAS
PubMed
Google Scholar
Casey CS, Atagi Y, Yamazaki Y, Shinohara M, Tachibana M, Fu Y, Bu G, Kanekiyo T. Apolipoprotein E inhibits cerebrovascular pericyte mobility through a RhoA Protein-mediated pathway. J Biol Chem. 2015;290:14208–21.
Chen J, Zeng F, Forrester SJ, Eguchi S, Zhang M-Z, Harris RC. Expression and function of the epidermal growth factor receptor in physiology and disease. Physiol Rev. 2016;96:1025–69.
Google Scholar
Doecke JD, Laws SM, Faux NG, Wilson W, Burnham SC, Lam CP, Mondal A, Bedo J, Bush AI, Brown B, et al. Blood-based protein biomarkers for diagnosis of Alzheimer disease. Arch Neurol. 2012;69:1318–25.
Article
PubMed
Google Scholar
Donnini S, Solito R, Cetti E, Corti F, Giachetti A, Carra S, Beltrame M, Cotelli F, Ziche M. Abeta peptides accelerate the senescence of endothelial cells in vitro and in vivo, impairing angiogenesis. FASEB J. 2010;24:2385–95.
Article
CAS
PubMed
Google Scholar
Farrer LA, Cupples LA, Haines JL, Hyman B, Kukull WA, Mayeux R, Myers RH, Pericak-Vance MA, Risch N, van Duijn CM. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis APOE and Alzheimer disease meta analysis consortium. JAMA. 1997;278:1349–56.
Article
CAS
PubMed
Google Scholar
Finch CE, Shams S. Apolipoprotein E and sex bias in cerebrovascular aging of Men and mice. Trends Neurosci. 2016;39:625–37.
Article
CAS
PubMed
Google Scholar
Grootendorst J, Bour A, Vogel E, Kelche C, Sullivan PM, Dodart JC, Bales K, Mathis C. Human apoE targeted replacement mouse lines: h-apoE4 and h-apoE3 mice differ on spatial memory performance and avoidance behavior. Behav Brain Res. 2005;159:1–14.
Article
CAS
PubMed
Google Scholar
Halliday MR, Rege SV, Ma Q, Zhao Z, Miller CA, Winkler EA, Zlokovic BV. Accelerated pericyte degeneration and blood–brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer's disease. J Cereb Blood Flow Metab. 2016;36:216–27.
CAS
PubMed
Google Scholar
Huang Y, Mahley RW. Apolipoprotein E: structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases. Neurobiol Dis 72. 2014; Pt A: 3–12
Humpel C, Hochstrasser T. Cerebrospinal fluid and blood biomarkers in Alzheimer's disease. World J Psychiatry. 2011;1:8–18.
Article
PubMed
PubMed Central
Google Scholar
Jantaratnotai N, Ryu JK, Schwab C, McGeer PL, McLarnon JG. Comparison of vascular perturbations in an abeta-injected animal model and in AD brain. Int J Alzheimers Dis. 2011;2011:918280.
PubMed
PubMed Central
Google Scholar
Jefferies WA, Price KA, Biron KE, Fenninger F, Pfeifer CG, Dickstein DL. Adjusting the compass: new insights into the role of angiogenesis in Alzheimer's disease. Alzheimers Res Ther. 2013;5:64.
Article
PubMed
PubMed Central
Google Scholar
Kalaria RN, Ballard C. Overlap between pathology of Alzheimer disease and vascular dementia. Alzheimer Dis Assoc Disord. 1999;13 Suppl 3:S115–123.
Article
PubMed
Google Scholar
Kipp M, Hochstrasser T, Schmitz C, Beyer C. Female sex steroids and glia cells: Impact on multiple sclerosis lesion formation and fine tuning of the local neurodegenerative cellular network. Neurosci Biobehav Rev. 2016;67:125–36.
Article
CAS
PubMed
Google Scholar
Kitaguchi H, Ihara M, Saiki H, Takahashi R, Tomimoto H. Capillary beds are decreased in Alzheimer's disease, but not in Binswanger's disease. Neurosci Lett. 2007;417:128–31.
Article
CAS
PubMed
Google Scholar
Komurcu HF, Kilic N, Demirbilek ME, Akin KO. Plasma levels of vitamin B12, epidermal growth factor and tumor necrosis factor alpha in patients with alzheimer dementia. Int J Res Med Sci. 2016;4:734–8.
Article
Google Scholar
Koster KP, Thomas R, Morris AW, Tai LM. Epidermal growth factor prevents oligomeric amyloid-beta induced angiogenesis deficits in vitro. J Cereb Blood Flow Metab. 2016. [Epub ahead of print].
Lee ST, Chu K, Park JE, Jung KH, Jeon D, Lim JY, Lee SK, Kim M, Roh JK. Erythropoietin improves memory function with reducing endothelial dysfunction and amyloid-beta burden in Alzheimer's disease models. J Neurochem. 2012;120:115–24.
Article
CAS
PubMed
Google Scholar
Lim NS, Swanson CR, Cherng HR, Unger TL, Xie SX, Weintraub D, Marek K, Stern MB, Siderowf A, Investigators P, et al. Plasma EGF and cognitive decline in Parkinson's disease and Alzheimer's disease. Ann Clin Transl Neurol. 2016;3:346–55.
Article
CAS
PubMed
PubMed Central
Google Scholar
Liu CC, Kanekiyo T, Xu H, Bu G. Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy. Nat Rev Neurol. 2013;9:106–18.
Article
CAS
PubMed
PubMed Central
Google Scholar
Liu DS, Pan XD, Zhang J, Shen H, Collins NC, Cole AM, Koster KP, Ben Aissa M, Dai XM, Zhou M, et al. APOE4 enhances age-dependent decline in cognitive function by down-regulating an NMDA receptor pathway in EFAD-Tg mice. Mol Neurodegener. 2015;10:7.
Article
PubMed
PubMed Central
Google Scholar
Love S, Miners JS. Cerebrovascular disease in ageing and Alzheimer's disease. Acta Neuropathol. 2016;131:645–58.
Article
CAS
PubMed
Google Scholar
Mahley RW, Rall Jr SC. Apolipoprotein E: far more than a lipid transport protein. Annu Rev Genomics Hum Genet. 2000;1:507–37.
Article
CAS
PubMed
Google Scholar
Na W, Lee JY, Kim WS, Yune TY, Ju BG. 17beta-estradiol ameliorates tight junction disruption via repression of MMP transcription. Mol Endocrinol. 2015;29:1347–61.
Article
CAS
PubMed
Google Scholar
Paris D, Patel N, DelleDonne A, Quadros A, Smeed R, Mullan M. Impaired angiogenesis in a transgenic mouse model of cerebral amyloidosis. Neurosci Lett. 2004;366:80–5.
Article
CAS
PubMed
Google Scholar
Patel NS, Mathura VS, Bachmeier C, Beaulieu-Abdelahad D, Laporte V, Weeks O, Mullan M, Paris D. Alzheimer's beta-amyloid peptide blocks vascular endothelial growth factor mediated signaling via direct interaction with VEGFR-2. J Neurochem. 2010;112:66–76.
Article
CAS
PubMed
Google Scholar
Payami H, Zareparsi S, Montee KR, Sexton GJ, Kaye JA, Bird TD, Yu CE, Wijsman EM, Heston LL, Litt M, et al. Gender difference in apolipoprotein E-associated risk for familial Alzheimer disease: a possible clue to the higher incidence of Alzheimer disease in women. Am J Hum Genet. 1996;58:803–11.
CAS
PubMed
PubMed Central
Google Scholar
Perheentupa J, Lakshmanan J, Hoath SB, Beri U, Kim H, Macaso T, Fisher DA. Epidermal growth factor measurements in mouse plasma: method, ontogeny, and sex difference. Am J Physiol. 1985;248:E391–396.
CAS
PubMed
Google Scholar
Phillips MC. Apolipoprotein E isoforms and lipoprotein metabolism. IUBMB Life. 2014;66:616–23.
Article
CAS
PubMed
Google Scholar
Religa P, Cao R, Religa D, Xue Y, Bogdanovic N, Westaway D, Marti HH, Winblad B, Cao Y. VEGF significantly restores impaired memory behavior in Alzheimer's mice by improvement of vascular survival. Sci Rep. 2013;3:2053.
Article
PubMed
PubMed Central
Google Scholar
Riedel BC, Thompson PM, Brinton RD. Age, APOE and sex: triad of risk of Alzheimer's disease. J Steroid Biochem Mol Biol. 2016;160:134–47.
Article
CAS
PubMed
Google Scholar
Rodriguez GA, Burns MP, Weeber EJ, Rebeck GW. Young APOE4 targeted replacement mice exhibit poor spatial learning and memory, with reduced dendritic spine density in the medial entorhinal cortex. Learn Mem. 2013;20:256–66.
Article
CAS
PubMed
PubMed Central
Google Scholar
Solito R, Corti F, Fossati S, Mezhericher E, Donnini S, Ghiso J, Giachetti A, Rostagno A, Ziche M. Dutch and arctic mutant peptides of beta amyloid(1–40) differentially affect the FGF-2 pathway in brain endothelium. Exp Cell Res. 2009;315:385–95.
Article
CAS
PubMed
Google Scholar
Tai LM, Bilousova T, Jungbauer L, Roeske SK, Youmans KL, Yu C, Poon WW, Cornwell LB, Miller CA, Vinters HV, et al. Levels of soluble apolipoprotein E/amyloid-beta (Abeta) complex are reduced and oligomeric Abeta increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples. J Biol Chem. 2013;288:5914–26.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tai LM, Ghura S, Koster KP, Liakaite V, Maienschein-Cline M, Kanabar P, Collins N, Ben-Aissa M, Lei AZ, Bahroos N, et al. APOE-modulated Abeta-induced neuroinflammation in Alzheimer's disease: current landscape, novel data and future perspective. J Neurochem. 2015;133(4):465–88.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tai LM, Thomas R, Marottoli FM, Koster KP, Kanekiyo T, Morris AW, Bu G. The role of APOE in cerebrovascular dysfunction. Acta Neuropathol. 2016;131(5):709–23.
Article
CAS
PubMed
Google Scholar
Tai LM, Youmans KL, Jungbauer L, Yu C, Ladu MJ. Introducing human APOE into abeta transgenic mouse models. Int J Alzheimers Dis. 2011;2011:810981.
PubMed
PubMed Central
Google Scholar
Tuomela T, Miettinen P, Pesonen K, Viinikka L, Perheentupa J. Epidermal growth factor in mice: effects of estradiol, testosterone and dexamethasone. Acta Endocrinol (Copenh). 1990;123:211–7.
CAS
Google Scholar
Tuomela T, Viinikka L, Perheentupa J. Epidermal growth factor in mice: changes during circadian and female reproductive cycles. Acta Endocrinol (Copenh). 1990;123:643–8.
CAS
Google Scholar
Vagnucci Jr AH, Li WW. Alzheimer's disease and angiogenesis. Lancet. 2003;361:605–8.
Article
CAS
PubMed
Google Scholar
Verghese PB, Castellano JM, Holtzman DM. Apolipoprotein E in Alzheimer's disease and other neurological disorders. Lancet Neurol. 2011;10:241–52.
Article
CAS
PubMed
PubMed Central
Google Scholar
Villasana L, Acevedo S, Poage C, Raber J. Sex- and APOE isoform-dependent effects of radiation on cognitive function. Radiat Res. 2006;166:883–91.
Article
CAS
PubMed
Google Scholar
Wang L, Chiang HC, Wu W, Liang B, Xie Z, Yao X, Ma W, Du S, Zhong Y. Epidermal growth factor receptor is a preferred target for treating amyloid-beta-induced memory loss. Proc Natl Acad Sci U S A. 2012;109:16743–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wang P, Xie ZH, Guo YJ, Zhao CP, Jiang H, Song Y, Zhu ZY, Lai C, Xu SL, Bi JZ. VEGF-induced angiogenesis ameliorates the memory impairment in APP transgenic mouse model of Alzheimer's disease. Biochem Biophys Res Commun. 2011;411:620–6.
Article
CAS
PubMed
Google Scholar
Weisgraber KH, Innerarity TL, Mahley RW. Abnormal lipoprotein receptor-binding activity of the human E apoprotein due to cysteine-arginine interchange at a single site. J Biol Chem. 1982;257:2518–21.
CAS
PubMed
Google Scholar
Yadav M, Singh AK, Kumar H, Rao G, Chakravarti B, Gurjar A, Dogra S, Kushwaha S, Vishwakarma AL, Yadav PN, et al. Epidermal growth factor receptor inhibitor cancer drug gefitinib modulates cell growth and differentiation of acute myeloid leukemia cells via histamine receptors. Biochim Biophys Acta Gen Subj. 2016;1860:2178–90.
Article
CAS
Google Scholar
Youmans KL, Tai LM, Nwabuisi-Heath E, Jungbauer L, Kanekiyo T, Gan M, Kim J, Eimer WA, Estus S, Rebeck GW, et al. APOE4-specific changes in abeta accumulation in a New transgenic mouse model of Alzheimer disease. J Biol Chem. 2012;287:41774–86.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yuede CM, Zimmerman SD, Dong H, Kling MJ, Bero AW, Holtzman DM, Timson BF, Csernansky JG. Effects of voluntary and forced exercise on plaque deposition, hippocampal volume, and behavior in the Tg2576 mouse model of Alzheimer's disease. Neurobiol Dis. 2009;35:426–32.
Article
CAS
PubMed
PubMed Central
Google Scholar