Fig. 2

Lower laminin coverage in E4FADF mice. a–c Laminin (basement membrane protein) staining is lower in E4FADF mice in brain regions of extracellular Aβ pathology: the subiculum and deep layers of the cortex (Dl-Cx) but not significantly different in the full-length cortex (Fl-Cx) between groups when assessed by IHC analysis. Further, E3FADF mice exhibit lower staining than E3FADM mice. d Extracellular Aβ levels are highest in E4FADF mice (IHC analysis using the antibody MOAB2). e Plasma EGF levels are low in EFADF mice. n = 7(E3FADM), 7 (E3FADF), 9 (E4FADM), 8 (E4FADF) when assessed by ELISA. Data expressed as mean +/− S.E.M. *p < 0.05 by two-way ANOVA and Tukey’s post hoc comparisons. ^# p < 0.05 by Student’s t-test