Fig. 1

Cognitive and cerebrovascular dysfunction in E4FADF mice. a E4FADF mice are cognitive impaired when assessed by novel object recognition and spontaneous alternation. b There are higher NaFl levels in the cortex (Cx) and hippocampus (Hp) of E4FADF mice after i.p injection. n = 7(E3FADM), 6 (E3FADF), 9 (E4FADM), 7 (E4FADF). c Prussian blue staining (microbleeds) is higher in the Cx and Hp of E4FADF mice when assessed by IHC analysis. n = 7 (E3FADM), 7 (E3FADF), 9 (E4FADM), 8 (E4FADF). Data expressed as mean +/− S.E.M. *p < 0.05 by two-way ANOVA and Tukey’s post hoc comparisons. #p < 0.05 by two-way AVOVA followed Fisher’s LSD test