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  1. Content type: Research

    Cerebellar hemorrhagic injury (CHI) is being recognized more frequently in premature infants. However, much of what we know about CHI neuropathology is from autopsy studies that date back to a prior era of neo...

    Authors: Krista M Haines, Wei Wang and Christopher R Pierson

    Citation: Acta Neuropathologica Communications 2013 1:69

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  2. Content type: Research

    Cases of Frontotemporal Lobar Degeneration (FTLD) and Motor Neurone Disease (MND) associated with expansions in C9ORF72 gene are characterised pathologically by the presence of TDP-43 negative, but p62 positive, ...

    Authors: David MA Mann, Sara Rollinson, Andrew Robinson, Janis Bennion Callister, Jennifer C Thompson, Julie S Snowden, Tania Gendron, Leonard Petrucelli, Masami Masuda-Suzukake, Masato Hasegawa, Yvonne Davidson and Stuart Pickering-Brown

    Citation: Acta Neuropathologica Communications 2013 1:68

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  3. Content type: Research

    Previous reports indicate the presence of histological abnormalities in the brains of individuals with autism spectrum disorders (ASD) suggestive of a dysplastic process. In this study we identified areas of a...

    Authors: Manuel F Casanova, Ayman S El-Baz, Shweta S Kamat, Brynn A Dombroski, Fahmi Khalifa, Ahmed Elnakib, Ahmed Soliman, Anita Allison-McNutt and Andrew E Switala

    Citation: Acta Neuropathologica Communications 2013 1:67

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  4. Content type: Research

    Medulloblastoma is the most common malignant brain tumor in children. Genetic profiling has identified four principle tumor subgroups; each subgroup is characterized by different initiating mutations, genetic ...

    Authors: Kelsey L Whittier, Erin A Boese, Katherine N Gibson-Corley, Patricia A Kirby, Benjamin W Darbro, Qining Qian, Wendy J Ingram, Thomas Robertson, Marc Remke, Michael D Taylor and M Sue O’Dorisio

    Citation: Acta Neuropathologica Communications 2013 1:66

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  5. Content type: Research

    Autopsy series commonly report a high percentage of coincident pathologies in demented patients, including patients with a clinical diagnosis of dementia of the Alzheimer type (DAT). However many clinical and ...

    Authors: Jon B Toledo, Nigel J Cairns, Xiao Da, Kewei Chen, Deborah Carter, Adam Fleisher, Erin Householder, Napatkamon Ayutyanont, Auttawut Roontiva, Robert J Bauer, Paul Eisen, Leslie M Shaw, Christos Davatzikos, Michael W Weiner, Eric M Reiman, John C Morris…

    Citation: Acta Neuropathologica Communications 2013 1:65

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  6. Content type: Research

    There is an emerging association between ketamine abuse and the development of urological symptoms including dysuria, frequency and urgency, which have a neurological component. In addition, extreme cases are ...

    Authors: Simon C Baker, Jens Stahlschmidt, Jon Oxley, Jennifer Hinley, Ian Eardley, Fiona Marsh, David Gillatt, Simon Fulford and Jennifer Southgate

    Citation: Acta Neuropathologica Communications 2013 1:64

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  7. Content type: Research

    Congenital cytomegalovirus (CMV) infection is a leading cause of sensorineural hearing loss (SNHL). The mechanisms of pathogenesis of CMV-related SNHL are still unclear. The aim is to study congenital CMV-rela...

    Authors: Liliana Gabrielli, Maria Paola Bonasoni, Donatella Santini, Giulia Piccirilli, Angela Chiereghin, Brunella Guerra, Maria Paola Landini, Maria Grazia Capretti, Marcello Lanari and Tiziana Lazzarotto

    Citation: Acta Neuropathologica Communications 2013 1:63

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  8. Content type: Review

    For the last 20 years, the “amyloid cascade hypothesis” has dominated research aimed at understanding, preventing, and curing Alzheimer’s disease (AD). During that time researchers have acquired an enormous am...

    Authors: Dimitrije Krstic and Irene Knuesel

    Citation: Acta Neuropathologica Communications 2013 1:62

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  9. Content type: Research

    Autism is a neurodevelopmental disorder of unknown etiopathogenesis associated with structural and functional abnormalities of neurons and increased formation of reactive oxygen species. Our previous study rev...

    Authors: Janusz Frackowiak, Bozena Mazur-Kolecka, N Carolyn Schanen, W Ted Brown and Jerzy Wegiel

    Citation: Acta Neuropathologica Communications 2013 1:61

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  10. Content type: Research

    The Arctic mutation (p.E693G/p.E22G)fs within the β-amyloid (Aβ) region of the β-amyloid precursor protein gene causes an autosomal dominant disease with clinical picture of typical Alzheimer’s disease. Here w...

    Authors: Hannu Kalimo, Maciej Lalowski, Nenad Bogdanovic, Ola Philipson, Thomas D Bird, David Nochlin, Gerard D Schellenberg, RoseMarie Brundin, Tommie Olofsson, Rabah Soliymani, Marc Baumann, Oliver Wirths, Thomas A Bayer, Lars NG Nilsson, Hans Basun, Lars Lannfelt…

    Citation: Acta Neuropathologica Communications 2013 1:60

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  11. Content type: Research

    Axon degeneration, a key pathological event in many neurodegenerative diseases and injury, can be induced by somatodendritic excitotoxin exposure. It is currently unclear, however, whether excitotoxin-induced ...

    Authors: Anna Elizabeth King, Katherine Adriana Southam, Justin Dittmann and James Clement Vickers

    Citation: Acta Neuropathologica Communications 2013 1:59

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  12. Content type: Research

    Cobblestone lissencephaly is a severe neuronal migration disorder associated with congenital muscular dystrophies (CMD) such as Walker-Warburg syndrome, muscle-eye-brain disease, and Fukuyama-type CMD. In thes...

    Authors: Huy Nguyen, Adam P Ostendorf, Jakob S Satz, Steve Westra, Susan E Ross-Barta, Kevin P Campbell and Steven A Moore

    Citation: Acta Neuropathologica Communications 2013 1:58

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  13. Content type: Research

    Persistent neuroinflammation and disruptions in brain energy metabolism is commonly seen in traumatic brain injury (TBI). Because of the lack of success of most TBI interventions and the documented benefits of...

    Authors: Teresita L Briones, Julie Woods and Magdalena Rogozinska

    Citation: Acta Neuropathologica Communications 2013 1:57

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  14. Content type: Research

    The amyloid hypothesis in Alzheimer disease (AD) considers amyloid β peptide (Aβ) deposition causative in triggering down-stream events like neurofibrillary tangles, cell loss, vascular damage and memory decli...

    Authors: Gregory Antonios, Nasrin Saiepour, Yvonne Bouter, Bernhard C Richard, Anders Paetau, Auli Verkkoniemi-Ahola, Lars Lannfelt, Martin Ingelsson, Gabor G Kovacs, Thierry Pillot, Oliver Wirths and Thomas A Bayer

    Citation: Acta Neuropathologica Communications 2013 1:56

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  15. Content type: Research

    The pathological features of the common neurodegenerative conditions, Alzheimer’s disease (AD), Parkinson’s disease and multiple sclerosis are all known to be associated with iron dysregulation in regions of t...

    Authors: Animesh Alexander Raha, Radhika Anand Vaishnav, Robert Paul Friedland, Adrian Bomford and Ruma Raha-Chowdhury

    Citation: Acta Neuropathologica Communications 2013 1:55

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  16. Content type: Research

    Intracytoplasmic inclusions composed of filamentous tau proteins are defining characteristics of neurodegenerative tauopathies, but it remains unclear why different tau isoforms accumulate in different disease...

    Authors: Ayaho Dan, Muneaki Takahashi, Masami Masuda-Suzukake, Fuyuki Kametani, Takashi Nonaka, Hiromi Kondo, Haruhiko Akiyama, Takao Arai, David MA Mann, Yuko Saito, Hiroyuki Hatsuta, Shigeo Murayama and Masato Hasegawa

    Citation: Acta Neuropathologica Communications 2013 1:54

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  17. Content type: Research

    In theory, cerebral biopsies could provide the diagnosis in a significant proportion of patients with neurodegenerative diseases, however, there are considerable ethical barriers. Previous series of cerebral b...

    Authors: Andrew King, Satomi Maekawa, Istvan Bodi, Claire Troakes, Olimpia Curran, Keyoumars Ashkan and Safa Al-Sarraj

    Citation: Acta Neuropathologica Communications 2013 1:53

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  18. Content type: Research

    Blast-induced neurotrauma (BINT) is the signature life threatening injury of current military casualties. Neuroinflammation is a key pathological occurrence of secondary injury contributing to brain damage aft...

    Authors: Yansong Li, Mikulas Chavko, Jessica L Slack, Bin Liu, Richard M McCarron, James D Ross and Jurandir J Dalle Lucca

    Citation: Acta Neuropathologica Communications 2013 1:52

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  19. Content type: Research

    Blast-related traumatic brain injury (TBI) has been a significant cause of injury in the military operations of Iraq and Afghanistan, affecting as many as 10-20% of returning veterans. However, how blast waves...

    Authors: Miguel A Gama Sosa, Rita De Gasperi, Alejandro J Paulino, Paul E Pricop, Michael C Shaughness, Eric Maudlin-Jeronimo, Aaron A Hall, William G M Janssen, Frank J Yuk, Nathan P Dorr, Dara L Dickstein, Richard M McCarron, Mikulas Chavko, Patrick R Hof, Stephen T Ahlers and Gregory A Elder

    Citation: Acta Neuropathologica Communications 2013 1:51

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  20. Content type: Research

    We have sought histological evidence, using TDP-43 and p62 immunohistochemistry, for the presence of expansions in C9ORF72 among 200 patients with pathologically confirmed AD.

    Authors: Yvonne S Davidson, Andrew C Robinson, Julie S Snowden and David MA Mann

    Citation: Acta Neuropathologica Communications 2013 1:50

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  21. Content type: Research

    TAR DNA-binding protein 43 (TDP-43) is a protein that is involved in the pathology of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Lobar Degeneration (FTLD). In patients with these neurodegenerative ...

    Authors: Rui Liu, Guang Yang, Takashi Nonaka, Tetsuaki Arai, William Jia and Max S Cynader

    Citation: Acta Neuropathologica Communications 2013 1:49

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  22. Content type: Research

    Basement membranes in the walls of cerebral capillaries and arteries form a major lymphatic drainage pathway for fluid and solutes from the brain. Amyloid-β (Aβ) draining from the brain is deposited in such pe...

    Authors: Roxana Octavia Carare, Jessica Liesbeth Teeling, Cheryl A Hawkes, Ursula Püntener, Roy O Weller, James AR Nicoll and Victor Hugh Perry

    Citation: Acta Neuropathologica Communications 2013 1:48

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  23. Content type: Research

    Focal cortical dysplasias (FCD) are local disturbances of neocortical architecture and a common cause of pharmaco-resistant focal epilepsy. Little is known about the pathomechanisms leading to architectural ab...

    Authors: Susanne Fauser, Ute Häussler, Catharina Donkels, Susanne Huber, Julia Nakagawa, Marco Prinz, Andreas Schulze-Bonhage, Josef Zentner and Carola A Haas

    Citation: Acta Neuropathologica Communications 2013 1:47

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  24. Content type: Research

    Presenilin-1 (PS1) is the active component of the amyloid precursor protein cleaving γ-secretase complex. PS1 protein is a transmembrane protein containing multiple hydrophobic regions which presence in cerebr...

    Authors: María-Salud García-Ayllón, María-Letizia Campanari, Gunnar Brinkmalm, Alberto Rábano, Jordi Alom, Carlos A Saura, Niels Andreasen, Kaj Blennow and Javier Sáez-Valero

    Citation: Acta Neuropathologica Communications 2013 1:46

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  25. Content type: Case report

    Monosomy 1p36 is the most common subtelomeric chromosomal deletion linked to mental retardation and seizures. Neuroimaging studies suggest that monosomy 1p36 is associated with brain malformations including po...

    Authors: Naoko Shiba, Ray AM Daza, Lisa G Shaffer, A James Barkovich, William B Dobyns and Robert F Hevner

    Citation: Acta Neuropathologica Communications 2013 1:45

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  26. Content type: Methodology article

    PrPSc, the only known constituent of prions, the infectious agents causing prion diseases, can be detected by real-time quaking-induced conversion (RT-QuIC). However, there is no efficient method to quantify the ...

    Authors: Song Shi, Gerda Mitteregger-Kretzschmar, Armin Giese and Hans A Kretzschmar

    Citation: Acta Neuropathologica Communications 2013 1:44

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  27. Content type: Research

    Foamy macrophages, containing myelin degradation products, are abundantly found in active multiple sclerosis (MS) lesions. Recent studies have described an altered phenotype of macrophages after myelin interna...

    Authors: Jeroen FJ Bogie, Winde Jorissen, Jo Mailleux, Philip G Nijland, Noam Zelcer, Tim Vanmierlo, Jack Van Horssen, Piet Stinissen, Niels Hellings and Jerome JA Hendriks

    Citation: Acta Neuropathologica Communications 2013 1:43

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  28. Content type: Research

    A pathological hallmark of most amyotrophic lateral sclerosis (ALS) cases are intracellular aggregates of the protein TDP-43. The pathophysiological relevance of TDP-43 is underlined by familial ALS cases caus...

    Authors: Axel Freischmidt, Kathrin Müller, Albert C Ludolph and Jochen H Weishaupt

    Citation: Acta Neuropathologica Communications 2013 1:42

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  29. Content type: Research

    Precocious development of Alzheimer-type neuropathological changes in epilepsy patients, especially in APOE ϵ4,4 carriers is well known, but not the ways in which other APOE allelic combinations influence this ou...

    Authors: Orwa Aboud, Robert E Mrak, Frederick A Boop and W Sue T Griffin

    Citation: Acta Neuropathologica Communications 2013 1:41

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  30. Content type: Research

    Central pontine myelinolysis (CPM) is a demyelinating disorder of the central basis pontis that is often associated with osmotic stress. The aquaporin water channels (AQPs) have been pathogenically implicated ...

    Authors: Bogdan F Gh Popescu, Reem F Bunyan, Yong Guo, Joseph E Parisi, Vanda A Lennon and Claudia F Lucchinetti

    Citation: Acta Neuropathologica Communications 2013 1:40

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  31. Content type: Research

    Aberrant neuron/glia interactions can contribute to a variety of neurodegenerative diseases and we have previously demonstrated that enhanced activation of Erb B2, which is a member of the epidermal growth fac...

    Authors: Pan Pan and Rick T Dobrowsky

    Citation: Acta Neuropathologica Communications 2013 1:39

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  32. Content type: Research

    α-Synuclein (αS) is the major component of several types of brain inclusions including Lewy bodies, a hallmark of Parkinson’s disease. Aberrant aggregation of αS also is associated with cellular demise in mult...

    Authors: Amanda N Sacino, Mieu Brooks, Nicholas H McGarvey, Alex B McKinney, Michael A Thomas, Yona Levites, Yong Ran, Todd E Golde and Benoit I Giasson

    Citation: Acta Neuropathologica Communications 2013 1:38

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  33. Content type: Research

    Calreticulin (CRT) is a chaperone protein, which aids correct folding of glycosylated proteins in the endoplasmic reticulum (ER). Under conditions of ER stress, CRT is upregulated and may be displayed on the s...

    Authors: Mary Ní Fhlathartaigh, Jill McMahon, Richard Reynolds, David Connolly, Eibhlín Higgins, Timothy Counihan and Una FitzGerald

    Citation: Acta Neuropathologica Communications 2013 1:37

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  34. Content type: Research

    Frontotemporal lobar degeneration (FTLD) is the second most common cause of dementia in individuals under 65 years old and manifests as alterations in behavior, personality, or language secondary to degenerati...

    Authors: Johanna I Busch, Maria Martinez-Lage, Emily Ashbridge, Murray Grossman, Vivianna M Van Deerlin, Fenghua Hu, Virginia MY Lee, John Q Trojanowski and Alice S Chen-Plotkin

    Citation: Acta Neuropathologica Communications 2013 1:36

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  35. Content type: Research

    Medulloblastomas, the most frequent malignant brain tumours affecting children, comprise at least 4 distinct clinicogenetic subgroups. Aberrant sonic hedgehog (SHH) signalling is observed in approximately 25% ...

    Authors: Maria Łastowska, Hani Al-Afghani, Haya H Al-Balool, Harsh Sheth, Emma Mercer, Jonathan M Coxhead, Chris PF Redfern, Heiko Peters, Alastair D Burt, Mauro Santibanez-Koref, Chris M Bacon, Louis Chesler, Alistair G Rust, David J Adams, Daniel Williamson, Steven C Clifford…

    Citation: Acta Neuropathologica Communications 2013 1:35

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  36. Content type: Research

    Tau is a microtubule stabilizing protein and is mainly expressed in neurons. Tau aggregation into oligomers and tangles is considered an important pathological event in tauopathies, such as frontotemporal deme...

    Authors: Josien Levenga, Pavan Krishnamurthy, Hameetha Rajamohamedsait, Helen Wong, Thomas F Franke, Peter Cain, Einar M Sigurdsson and Charles A Hoeffer

    Citation: Acta Neuropathologica Communications 2013 1:34

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  37. Content type: Research

    Two commercially available TDP43 antibodies (phosphorylated or pTDP43, non-phosphorylated or iTDP43) are currently in use for the neuropathological classification of FTLD-TDP cases into pathological subtypes. ...

    Authors: Rachel H Tan, Claire E Shepherd, Jillian J Kril, Heather McCann, Andrew McGeachie, Ciara McGinley, Andrew Affleck and Glenda M Halliday

    Citation: Acta Neuropathologica Communications 2013 1:33

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  38. Content type: Research

    Neuroinflammation regulates both disease pathogenesis and repair in multiple sclerosis. In early multiple sclerosis lesion development, neuroinflammation causes demyelination and axonal injury, the likely fina...

    Authors: Vilija G Jokubaitis, Melissa M Gresle, Dennis A Kemper, William Doherty, Victoria M Perreau, Tania L Cipriani, Anna Jonas, Gerry Shaw, Tanja Kuhlmann, Trevor J Kilpatrick and Helmut Butzkueven

    Citation: Acta Neuropathologica Communications 2013 1:32

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  39. Content type: Research

    Progressive supranuclear palsy (PSP) is a neurodegenerative disorder pathologically characterized by intracellular tangles of hyperphosphorylated tau protein distributed throughout the neocortex, basal ganglia...

    Authors: Lauren D Stutzbach, Sharon X Xie, Adam C Naj, Roger Albin, Sid Gilman, Virginia M Y Lee, John Q Trojanowski, Bernie Devlin and Gerard D Schellenberg

    Citation: Acta Neuropathologica Communications 2013 1:31

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  40. Content type: Research

    Early atrophy of the cingulate cortex is a feature of both behavioral variant frontotemporal dementia (bvFTD) and Alzheimer’s disease (AD), with degeneration of the anterior cingulate region increasingly recog...

    Authors: Rachel H Tan, Karen Pok, Stephanie Wong, Daniel Brooks, Glenda M Halliday and Jillian J Kril

    Citation: Acta Neuropathologica Communications 2013 1:30

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  41. Content type: Research

    Inclusion body myositis (IBM) is a slowly progressive inflammatory myopathy of the elderly that does not show significant clinical improvement in response to steroid therapy. Distinguishing IBM from polymyosit...

    Authors: Annie Hiniker, Brianne H Daniels, Han S Lee and Marta Margeta

    Citation: Acta Neuropathologica Communications 2013 1:29

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  42. Content type: Research

    A critical and as-yet unmet need in Alzheimer disease (AD) research is the development of novel markers that can identify individuals at risk for cognitive decline due to AD. This would aid intervention trials...

    Authors: Alison A Motsinger-Reif, Hongjie Zhu, Mitchel A Kling, Wayne Matson, Swati Sharma, Oliver Fiehn, David M Reif, Dina H Appleby, P Murali Doraiswamy, John Q Trojanowski, Rima Kaddurah-Daouk and Steven E Arnold

    Citation: Acta Neuropathologica Communications 2013 1:28

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  43. Content type: Research

    Reelin and its downstream signaling members are important modulators of actin and microtubule cytoskeleton dynamics, a fundamental prerequisite for proper neurodevelopment and adult neuronal functions. Reducti...

    Authors: Tina Notter and Irene Knuesel

    Citation: Acta Neuropathologica Communications 2013 1:27

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  44. Content type: Research

    Friedreich ataxia (FA) causes distinctive lesions of dorsal root ganglia (DRG), including neuronal atrophy, satellite cell hyperplasia, and absorption of dying nerve cells into residual nodules. Two mechanisms...

    Authors: Arnulf H Koeppen, Erik C Kuntzsch, Sarah T Bjork, R Liane Ramirez, Joseph E Mazurkiewicz and Paul J Feustel

    Citation: Acta Neuropathologica Communications 2013 1:26

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  45. Content type: Research

    In some prion diseases, misfolded aggregated protease-resistant prion protein (PrPres) is found in brain as amyloid, which can cause cerebral amyloid angiopathy. Small diffusible precursors of PrPres amyloid m...

    Authors: Alejandra Rangel, Brent Race, Mikael Klingeborn, James Striebel and Bruce Chesebro

    Citation: Acta Neuropathologica Communications 2013 1:25

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  46. Content type: Research

    Protein aggregation and the formation of intracellular inclusions are a central feature of many neurodegenerative disorders, but precise knowledge about their pathogenic role is lacking in most instances. Here...

    Authors: Marijn Kuijpers, Vera van Dis, Elize D Haasdijk, Martin Harterink, Karin Vocking, Jan A Post, Wiep Scheper, Casper C Hoogenraad and Dick Jaarsma

    Citation: Acta Neuropathologica Communications 2013 1:24

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  47. Content type: Research

    In utero exposure of the fetal non-human primate (NHP) brain to alcohol on a single occasion during early or late third-trimester gestation triggers widespread acute apoptotic death of cells in both gray and whi...

    Authors: Catherine E Creeley, Krikor T Dikranian, Stephen A Johnson, Nuri B Farber and John W Olney

    Citation: Acta Neuropathologica Communications 2013 1:23

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  48. Content type: Methodology article

    Our aim was to develop a new protocol for MGMT immunohistochemistry with good agreement between observers and good correlation with molecular genetic tests of tumour methylation. We examined 40 primary brain t...

    Authors: Elinor Burke, Mariana Grobler, Kay Elderfield, Frances Bond, Matthew Crocker, Rohan Taylor and Leslie R Bridges

    Citation: Acta Neuropathologica Communications 2013 1:22

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  49. Content type: Research

    Emerging evidence suggests that innate immunity and increased oxidative stress contribute to pathomechanisms in amyotrophic lateral sclerosis (ALS). The aim of the present study was to verify the involvement o...

    Authors: Motoko Kawaguchi-Niida, Tomoko Yamamoto, Yoichiro Kato, Yuri Inose and Noriyuki Shibata

    Citation: Acta Neuropathologica Communications 2013 1:21

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  50. Content type: Methodology article

    High frequencies of the BRAF V600E mutation have been reported in pleomorphic xanthoastrocytoma (PXA). Recently, a BRAF V600E mutation-specific antibody has been developed and validated. We evaluated the immun...

    Authors: Cristiane M Ida, Julie A Vrana, Fausto J Rodriguez, Mark E Jentoft, Alissa A Caron, Sarah M Jenkins and Caterina Giannini

    Citation: Acta Neuropathologica Communications 2013 1:20

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