- Letter to the Editor
- Open Access
GFAP canonical transcript may not be suitable for the diagnosis of adult-onset Alexander disease
© The Author(s). 2018
- Received: 20 September 2018
- Accepted: 11 October 2018
- Published: 24 October 2018
- Adult-onset Alexander disease
- Sanger sequencing
- Alternative transcripts
To the editor,
The authors are grateful to the patient reported here for giving them permission to share his data.
This work was supported by the Mayo Clinic Center for Individualized Medicine (CIM), the Investigative and Functional Genomics Program, and the William O. Lund, Jr. and Natalie C. Lund Charitable Foundation.
Availability of data and materials
FPV: acquisition, analysis, interpretation of data and writing. NB: acquisition of data and critical revision of the manuscript for intellectual content. EK: study supervision and critical revision of the manuscript for intellectual content. RHG: acquisition of data, supervision, and critical revision of the manuscript for intellectual content. All authors read and approved the final manuscript.
Ethics approval and consent to participate
This study was performed in accordance with the guidelines of Mayo Clinic Institutional Review Board (12–009346) and ethical standards laid down in the 1964 Declaration of Helsinki.
Consent for publication
The patient has consented for publication.
The authors declare that they have no competing interests.
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Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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