Kane MD, Lipinski WJ, Callahan MJ, Bian F, Durham RA, Schwarz RD, Roher AE, Walker LC: Evidence for seeding of β-amyloid by intracerebral infusion of Alzheimer brain extracts in β-amyloid precursor protein-transgenic mice. J Neurosci 2000, 20: 3606–3611.
CAS
PubMed
Google Scholar
Jucker M, Walker LC: Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders. Ann Neurol 2011, 70: 532–540. 10.1002/ana.22615
Article
CAS
PubMed
PubMed Central
Google Scholar
Clavaguera F, Akatsu H, Fraser G, Crowther RA, Frank S, Hench J, Probst A, Winkler DT, Reichwald J, Staufenbiel M, Ghetti B, Goedert M, Tolnay M: Brain homogenates from human tauopathies induce tau inclusions in mouse brain. Proc Natl Acad Sci 2013, 110: 9535–9540. 10.1073/pnas.1301175110
Article
CAS
PubMed
PubMed Central
Google Scholar
Clavaguera F, Lavenir I, Falcon B, Frank S, Goedert M, Tolnay M: “Prion-like” templated misfolding in tauopathies. Brain Pathol 2013, 23: 342–349. 10.1111/bpa.12044
Article
CAS
PubMed
Google Scholar
Clavaguera F, Bolmont T, Crowther RA, Abramowski D, Frank S, Probst A, Fraser G, Stalder AK, Beibel M, Staufenbiel M, Jucker M, Goedert M, Tolnay M: Transmission and spreading of tauopathy in transgenic mouse brain. Nat Cell Biol 2009, 11: 909–913. 10.1038/ncb1901
Article
CAS
PubMed
PubMed Central
Google Scholar
Iba M, Guo JL, McBride JD, Zhang B, Trojanowski JQ, Lee VMY: Synthetic Tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer’s-like tauopathy. J Neurosci 2013, 33: 1024–1037. 10.1523/JNEUROSCI.2642-12.2013
Article
CAS
PubMed
PubMed Central
Google Scholar
Rönnbäck A, Sagelius H, Bergstedt KD, Näslund J, Westermark GT, Winblad B, Graff C: Amyloid neuropathology in the single Arctic APP transgenic model affects interconnected brain regions. Neurobiol Aging 2012, 33: 831.e11–831.e19.
Article
Google Scholar
Lazarov O, Lee M, Peterson DA, Sisodia SS: Evidence that synaptically released beta-amyloid accumulates as extracellular deposits in the hippocampus of transgenic mice. J Neurosci 2002, 22: 9785–9793.
CAS
PubMed
Google Scholar
Brundin P, Melki R, Kopito R: Prion-like transmission of protein aggregates in neurodegenerative diseases. Nat Rev Mol Cell Biol 2010, 11: 301–307. 10.1038/nrm2873
Article
CAS
PubMed
PubMed Central
Google Scholar
Pan-Montojo F, Schwarz M, Winkler C, Arnhold M, O’Sullivan GA, Pal A, Said J, Marsico G, Verbavatz J-M, Rodrigo-Angulo M, Gille G, Funk RHW, Reichmann H: Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice. Sci Rep 2012, 2: 1–12.
Article
Google Scholar
Langer F, Eisele YS, Fritschi SK, Staufenbiel M, Walker LC, Jucker M: Soluble Aβ seeds are potent inducers of cerebral β-amyloid deposition. J Neurosci 2011, 31: 14488–14495. 10.1523/JNEUROSCI.3088-11.2011
Article
CAS
PubMed
PubMed Central
Google Scholar
Eisele YS, Bolmont T, Heikenwalder M, Langer F, Jacobson LH, Yan Z-X, Roth K, Aguzzi A, Staufenbiel M, Walker LC, Jucker M: Induction of cerebral beta-amyloidosis: intracerebral versus systemic Abeta inoculation. Proc Natl Acad Sci 2009, 106: 12926–12931. 10.1073/pnas.0903200106
Article
CAS
PubMed
PubMed Central
Google Scholar
Horikoshi Y, Mori T, Maeda M, Kinoshita N, Sato K, Yamaguchi H: Abeta N-terminal-end specific antibody reduced beta-amyloid in Alzheimer-model mice. Biochem Biophys Res Commun 2004, 325: 384–387. 10.1016/j.bbrc.2004.10.039
Article
CAS
PubMed
Google Scholar
Eisele YS, Obermuller U, Heilbronner G, Baumann F, Kaeser SA, Wolburg H, Walker LC, Staufenbiel M, Heikenwalder M, Jucker M: Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis. Science 2010, 330: 980–982. 10.1126/science.1194516
Article
CAS
PubMed
PubMed Central
Google Scholar
Lauritzen I, Pardossi-Piquard R, Bauer C, Brigham E, Abraham JD, Ranaldi S, Fraser P, St George-Hyslop P, Le Thuc O, Espin V, Chami L, Dunys J, Checler F: The β-secretase-derived C-terminal fragment of βAPP, C99, but Not Aβ, is a key contributor to early intraneuronal lesions in triple-transgenic mouse hippocampus. J Neurosci 2012, 32: 16243–16255. 10.1523/JNEUROSCI.2775-12.2012
Article
CAS
PubMed
Google Scholar
Kumar S, Wirths O, Theil S, Gerth J, Bayer TA, Walter J: Early intraneuronal accumulation and increased aggregation of phosphorylated Abeta in a mouse model of Alzheimer’s disease. Acta Neuropathol 2013, 125: 699–709. 10.1007/s00401-013-1107-8
Article
CAS
PubMed
Google Scholar
Wirths O, Dins A, Bayer TA: AβPP accumulation and/or intraneuronal amyloid-β accumulation? The 3xTg-AD mouse model revisited. J Alzheimers Dis 2012, 28: 897–904.
CAS
PubMed
Google Scholar
Thal DRD, Rüb UU, Orantes MM, Braak HH: Phases of A beta-deposition in the human brain and its relevance for the development of AD. Neurology 2002, 58: 1791–1800. 10.1212/WNL.58.12.1791
Article
PubMed
Google Scholar
Rönnbäck A, Zhu S, Dillner K, Aoki M, Lilius L, Näslund J, Winblad B, Graff C: Progressive neuropathology and cognitive decline in a single Arctic APP transgenic mouse model. Neurobiol Aging 2011, 32: 280–292. 10.1016/j.neurobiolaging.2009.02.021
Article
PubMed
Google Scholar
Sheng JG, Price DL, Koliatsos VE: Disruption of corticocortical connections ameliorates amyloid burden in terminal fields in a transgenic model of Abeta amyloidosis. J Neurosci 2002, 22: 9794–9799.
CAS
PubMed
Google Scholar
Tampellini D, Magrané J, Takahashi RH, Li F, Lin MT, Almeida CG, Gouras GK: Internalized antibodies to the Abeta domain of APP reduce neuronal Abeta and protect against synaptic alterations. J Biol Chem 2007, 282: 18895–18906. 10.1074/jbc.M700373200
Article
CAS
PubMed
Google Scholar
Amaral DG, Dolorfo C, Alvarez-Royo P: Organization of CA1 projections to the subiculum: a PHA-L analysis in the rat. Hippocampus 1991, 1: 415–435. 10.1002/hipo.450010410
Article
CAS
PubMed
Google Scholar
Long JM, Kalehua AN, Muth NJ, Calhoun ME: Stereological analysis of astrocyte and microglia in aging mouse hippocampus. Neurobiol Aging 1998, 19: 97–503. 10.1016/S0197-4580(97)00169-3
Article
Google Scholar
Mufson EJ, Lavine N, Jaffar S, Kordower JH, Quirion R, Saragovi HU: Reduction in p140-TrkA receptor protein within the nucleus basalis and cortex in Alzheimer’s disease. Exp Neurol 1997, 146: 91–103. 10.1006/exnr.1997.6504
Article
CAS
PubMed
Google Scholar
Wyss JM, Van Groen T: Connections between the retrosplenial cortex and the hippocampal formation in the rat: a review. Hippocampus 1992, 2: 1–11. 10.1002/hipo.450020102
Article
CAS
PubMed
Google Scholar
Sugar J, Witter MP, van Strien NM, Cappaert NLM: The retrosplenial cortex: intrinsic connectivity and connections with the (para)hippocampal region in the rat.An interactive connectome. Front Neuroinform 2011, 5: 7.
Article
PubMed
PubMed Central
Google Scholar
Commins S, Aggleton JP, O’Mara SM: Physiological evidence for a possible projection from dorsal subiculum to hippocampal area CA1. Exp Brain Res 2002, 146: 155–160. 10.1007/s00221-002-1158-x
Article
PubMed
Google Scholar
Frost B, Diamond MI: Prion-like mechanisms in neurodegenerative diseases. Nat Rev Neurosci 2009, 11: 155–159.
PubMed
PubMed Central
Google Scholar
Meyer-Luehmann M, Coomaraswamy J, Bolmont T, Kaeser S, Schaefer C, Kilger E, Neuenschwander A, Abramowski D, Frey P, Jaton AL, Vigouret JM, Paganetti P, Walsh DM, Mathews PM, Ghiso J, Staufenbiel M, Walker LC, Jucker M: Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host. Science 2006, 313: 1781–1784. 10.1126/science.1131864
Article
CAS
PubMed
Google Scholar
Heilbronner G, Eisele YS, Langer F, Kaeser SA, Novotny R, Nagarathinam A, Aslund A, Hammarström P, Nilsson KPR, Jucker M: Seeded strain-like transmission of β-amyloid morphotypes in APP transgenic mice. EMBO Rep 2013, 14: 1017–1022. 10.1038/embor.2013.137
Article
CAS
PubMed
PubMed Central
Google Scholar
Gouras GK, Tsai J, Naslund J, Vincent B, Edgar M, Checler F, Greenfield JP, Haroutunian V, Buxbaum JD, Xu H, Greengard P, Relkin NR: Intraneuronal Abeta42 accumulation in human brain. Am J Pathol 2000, 156: 15–20. 10.1016/S0002-9440(10)64700-1
Article
CAS
PubMed
PubMed Central
Google Scholar
Sisodia SS, Koo EH, Hoffman PN, Perry G, Price DL: Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system. J Neurosci 1993, 13: 3136–3142.
CAS
PubMed
Google Scholar
Braak H, Braak E: Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 1991, 82: 239–259. 10.1007/BF00308809
Article
CAS
PubMed
Google Scholar
Kamal A, Stokin GB, Yang Z, Xia CH, Goldstein LS: Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I. Neuron 2000, 28: 449–459. 10.1016/S0896-6273(00)00124-0
Article
CAS
PubMed
Google Scholar
Buxbaum JD, Thinakaran G, Koliatsos V, O’Callahan J, Slunt HH, Price DL, Sisodia SS: Alzheimer amyloid protein precursor in the rat hippocampus: transport and processing through the perforant path. J Neurosci 1998, 18: 9629–9637.
CAS
PubMed
Google Scholar
Yamazaki T, Selkoe DJ, Koo EH: Trafficking of cell surface beta-amyloid precursor protein: retrograde and transcytotic transport in cultured neurons. J Cell Biol 1995, 129: 431–442. 10.1083/jcb.129.2.431
Article
CAS
PubMed
Google Scholar
Muresan V, Varvel NH, Lamb BT, Muresan Z: The cleavage products of amyloid-beta precursor protein are sorted to distinct carrier vesicles that are independently transported within neurites. J Neurosci 2009, 29: 3565–3578. 10.1523/JNEUROSCI.2558-08.2009
Article
CAS
PubMed
PubMed Central
Google Scholar
Nath S, Agholme L, Kurudenkandy FR, Granseth B, Marcusson J, Hallbeck M: Spreading of neurodegenerative pathology via neuron-to-neuron transmission of β-amyloid. J Neurosci 2012, 32: 8767–8777. 10.1523/JNEUROSCI.0615-12.2012
Article
CAS
PubMed
Google Scholar
Tampellini D, Capetillo-Zarate E, Dumont M, Huang Z, Yu F, Lin MT, Gouras GK: Effects of synaptic modulation on beta-amyloid, synaptophysin, and memory performance in Alzheimer’s disease transgenic mice. J Neurosci 2010, 30: 14299–14304. 10.1523/JNEUROSCI.3383-10.2010
Article
CAS
PubMed
PubMed Central
Google Scholar
Braak H, Del Tredici K: Alzheimer’s pathogenesis: is there neuron-to-neuron propagation? Acta Neuropathol 2011, 121: 589–595. 10.1007/s00401-011-0825-z
Article
CAS
PubMed
Google Scholar
Robertson RT, Baratta J, Yu J, LaFerla FM: Amyloid- expression in retrosplenial cortex of triple transgenic mice: relationship to cholinergic axonal afferents from medial septum. Neuroscience 2009, 164: 1334–1346. 10.1016/j.neuroscience.2009.09.024
Article
CAS
PubMed
PubMed Central
Google Scholar