Illustration of the progressive diffuse amyloid deposition in homozygous TgAPParc mice with altered pathology following subiculum lesion. Anatomical connections between brain regions are marked by arrows. Colored text indicates the age when the first diffuse amyloid deposits are detected in the respective brain regions. Syringe marks the site of ibotenic acid lesion. Amyloid deposition affects functionally connected brain regions sequentially from the subiculum and brain structures receiving input from subiculum including the retrosplenial cortex, mammillary body, and thalamus. Decreased Aβ/C99 pathology was observed in the subiculum, CA1 and RSG (indicated). Schematic modified from Rönnback et al., 2012 , with permission.