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  1. In Alzheimer’s disease (AD), the distribution and density of neurofibrillary tangles, a histological hallmark comprised predominately of phosphorylated tau protein, follows a distinct pattern through anatomica...

    Authors: Siân Baker and Jürgen Götz
    Citation: Acta Neuropathologica Communications 2016 4:32
  2. IDH mutations are found in the majority of adult, diffuse, low-grade and anaplastic gliomas and are also frequently found in cartilaginous tumors. Ollier disease and Maffucci syndrome are...

    Authors: Charlotte Bonnet, Laure Thomas, Dimitri Psimaras, Franck Bielle, Elodie Vauléon, Hugues Loiseau, Stéphanie Cartalat-Carel, David Meyronet, Caroline Dehais, Jérôme Honnorat, Marc Sanson and François Ducray
    Citation: Acta Neuropathologica Communications 2016 4:31
  3. The phenotypic spectrum among girls with heterozygous mutations in the X-linked intellectual disability (XLID) gene CASK (calcium/calmodulin-dependent serine protein kinase) includes postnatal microcephaly, ponto...

    Authors: Sarika Srivastava, Ryan McMillan, Jeffery Willis, Helen Clark, Vrushali Chavan, Chen Liang, Haiyan Zhang, Matthew Hulver and Konark Mukherjee
    Citation: Acta Neuropathologica Communications 2016 4:30
  4. To clarify the role of α-synuclein (αSyn) in neuronal membrane remodeling, we analyzed the expression of αSyn in neurons with a dysfunction of PLA2G6, which is indispensable for membrane remodeling. αSyn/phosp...

    Authors: Hisae Sumi-Akamaru, Goichi Beck, Koei Shinzawa, Shinsuke Kato, Yuichi Riku, Mari Yoshida, Harutoshi Fujimura, Yoshihide Tsujimoto, Saburo Sakoda and Hideki Mochizuki
    Citation: Acta Neuropathologica Communications 2016 4:27
  5. Pneumococcal meningitis is associated with substantial mortality and morbidity. We systematically assessed brain histopathology of 31 patients who died of pneumococcal meningitis from a nationwide study (media...

    Authors: Joo-Yeon Engelen-Lee, Matthijs C. Brouwer, Eleonora Aronica and Diederik van de Beek
    Citation: Acta Neuropathologica Communications 2016 4:26
  6. Alzheimer’s disease (AD) is associated with the accumulation of β-amyloid (Aβ) as senile plaques in the brain, thus leading to neurodegeneration and cognitive impairment. Plaque formation depends not merely on...

    Authors: Luisa Möhle, Nicole Israel, Kristin Paarmann, Markus Krohn, Sabine Pietkiewicz, Andreas Müller, Inna N. Lavrik, Jeffrey S. Buguliskis, Björn H. Schott, Dirk Schlüter, Eckart D. Gundelfinger, Dirk Montag, Ulrike Seifert, Jens Pahnke and Ildiko Rita Dunay
    Citation: Acta Neuropathologica Communications 2016 4:25
  7. In Alzheimer’s disease (AD) a variety of amyloid β-peptides (Aβ) are deposited in the form of extracellular diffuse and neuritic plaques (NP), as well as within the vasculature. The generation of Aβ from its p...

    Authors: Jochim Reinert, Bernhard C. Richard, Hans W. Klafki, Beate Friedrich, Thomas A. Bayer, Jens Wiltfang, Gabor G. Kovacs, Martin Ingelsson, Lars Lannfelt, Anders Paetau, Jonas Bergquist and Oliver Wirths
    Citation: Acta Neuropathologica Communications 2016 4:24
  8. Guillain-Barré syndrome (GBS) is an autoimmune disease that results in acute paralysis through inflammatory attack on peripheral nerves, and currently has limited, non-specific treatment options. The pathogene...

    Authors: Rhona McGonigal, Madeleine E. Cunningham, Denggao Yao, Jennifer A. Barrie, Sethu Sankaranarayanan, Simon N. Fewou, Koichi Furukawa, Ted A. Yednock and Hugh J. Willison
    Citation: Acta Neuropathologica Communications 2016 4:23
  9. The accumulation of insoluble proteins within neurons and glia cells is a pathological hallmark of several neurodegenerative diseases. Abnormal aggregation of the microtubule-associated protein tau characteriz...

    Authors: Antonio Piras, Ludovic Collin, Fiona Grüninger, Caroline Graff and Annica Rönnbäck
    Citation: Acta Neuropathologica Communications 2016 4:22
  10. Authors: Christian P. Miermeister, Stephan Petersenn, Michael Buchfelder, Rudolf Fahlbusch, Dieter K. Lüdecke, Annett Hölsken, Markus Bergmann, Ulrich Johannes Knappe, Volkmar H. Hans, Jörg Flitsch, Wolfgang Saeger and Rolf Buslei
    Citation: Acta Neuropathologica Communications 2016 4:21

    The original article was published in Acta Neuropathologica Communications 2015 3:50

  11. Craniopharyngiomas (CP) are rare epithelial tumors of the sellar region. Two subtypes, adamantinomatous (adaCP) and papillary CP (papCP), were previously identified based on histomorphological and epidemiolog...

    Authors: Annett Hölsken, Martin Sill, Jessica Merkle, Leonille Schweizer, Michael Buchfelder, Jörg Flitsch, Rudolf Fahlbusch, Markus Metzler, Marcel Kool, Stefan M. Pfister, Andreas von Deimling, David Capper, David T. W. Jones and Rolf Buslei
    Citation: Acta Neuropathologica Communications 2016 4:20
  12. Neuronal death and subsequent denervation of target areas are hallmarks of many neurological disorders. Denervated neurons lose part of their dendritic tree, and are considered "atrophic", i.e. pathologically ...

    Authors: Steffen Platschek, Hermann Cuntz, Mario Vuksic, Thomas Deller and Peter Jedlicka
    Citation: Acta Neuropathologica Communications 2016 4:19
  13. The most common forms of amyotrophic lateral sclerosis and frontotemporal dementia are caused by a large GGGGCC repeat expansion in the first intron of the C9orf72 gene. The repeat-containing intron should be deg...

    Authors: Michael Niblock, Bradley N. Smith, Youn-Bok Lee, Valentina Sardone, Simon Topp, Claire Troakes, Safa Al-Sarraj, Claire S. Leblond, Patrick A. Dion, Guy A. Rouleau, Christopher E. Shaw and Jean-Marc Gallo
    Citation: Acta Neuropathologica Communications 2016 4:18
  14. Mutations of Tau are associated with several neurodegenerative disorders. Recently, the Tau mutation A152T was described as a novel risk factor for frontotemporal dementia spectrum disorders and Alzheimer dise...

    Authors: Astrid Sydow, Katja Hochgräfe, Stefanie Könen, Daniela Cadinu, Dorthe Matenia, Olga Petrova, Maria Joseph, Frank Johannes Dennissen and Eva-Maria Mandelkow
    Citation: Acta Neuropathologica Communications 2016 4:17
  15. Insulin resistance and type 2 diabetes mellitus (T2D) are associated with increased risk for cognitive impairment, Alzheimer’s disease (AD) and vascular dementia. SORCS1 encodes a protein-sorting molecule genetic...

    Authors: Elysse M. Knight, Henry H. Ruiz, Soong Ho Kim, Jessica C. Harte, Wilson Hsieh, Charles Glabe, William L. Klein, Alan D. Attie, Christoph Buettner, Michelle E. Ehrlich and Sam Gandy
    Citation: Acta Neuropathologica Communications 2016 4:16
  16. Increasing evidence implicates the role of the cell types surrounding motor neurons, such as interneurons and glial cells, in non-cell autonomous neurodegeneration of amyotrophic lateral sclerosis (ALS). C-bou...

    Authors: Jurate Lasiene, Okiru Komine, Noriko Fujimori-Tonou, Berit Powers, Fumito Endo, Seiji Watanabe, Jin Shijie, John Ravits, Philip Horner, Hidemi Misawa and Koji Yamanaka
    Citation: Acta Neuropathologica Communications 2016 4:15
  17. CSF levels of established Alzheimer’s disease (AD) biomarkers remain stable despite disease progression, and non-amyloid non-tau biomarkers have the potential of informing disease stage and progression. We pre...

    Authors: William T. Hu, Kelly D. Watts, Prashant Tailor, Trung P. Nguyen, Jennifer C. Howell, Raven C. Lee, Nicholas T. Seyfried, Marla Gearing, Chadwick M. Hales, Allan I. Levey, James J. Lah and Eva K. Lee
    Citation: Acta Neuropathologica Communications 2016 4:14
  18. Authors: Lindsey M. Hoffman, Mariko DeWire, Scott Ryall, Pawel Buczkowicz, James Leach, Lili Miles, Arun K. Ramani, Michael Brudno, Shiva Senthil Kumar, Rachid Drissi, Phillip Dexheimer, Ralph Salloum, Lionel Chow, Trent Hummel, Charles Stevenson, Q. Richard Lu…
    Citation: Acta Neuropathologica Communications 2016 4:13

    The original article was published in Acta Neuropathologica Communications 2016 4:1

  19. Multiple system atrophy (MSA) is a rare, yet rapidly-progressive neurodegenerative disease that presents clinically with autonomic failure in combination with parkinsonism or cerebellar ataxia. The definitive ...

    Authors: Jonathan M. Bleasel, Glenda M. Halliday and Woojin Scott Kim
    Citation: Acta Neuropathologica Communications 2016 4:12
  20. Deposition of abnormally phosphorylated tau (phospho-tau) occurs in Alzheimer’sdisease but also with brain ageing. The Braak staging scheme focused on neurofibrillary tangles, butabundant p-tau is also present...

    Authors: Stephen B. Wharton, Thais Minett, David Drew, Gillian Forster, Fiona Matthews, Carol Brayne and Paul G. Ince
    Citation: Acta Neuropathologica Communications 2016 4:11
  21. Mammalian prions are proteinaceous pathogens responsible for a broad range of fatal neurodegenerative diseases in humans and animals. These diseases can occur spontaneously, such as Creutzfeldt-Jakob disease (...

    Authors: Jérôme Chapuis, Mohammed Moudjou, Fabienne Reine, Laetitia Herzog, Emilie Jaumain, Céline Chapuis, Isabelle Quadrio, Jacques Boulliat, Armand Perret-Liaudet, Michel Dron, Hubert Laude, Human Rezaei and Vincent Béringue
    Citation: Acta Neuropathologica Communications 2016 4:10
  22. Limb girdle muscular dystrophies are a large group of both dominantly and recessively inherited muscle diseases. LGMD1D is caused by mutated DNAJB6 and the molecular pathogenesis is mediated by defective chape...

    Authors: Satu Sandell, Sanna Huovinen, Johanna Palmio, Olayinka Raheem, Mikaela Lindfors, Fang Zhao, Hannu Haapasalo and Bjarne Udd
    Citation: Acta Neuropathologica Communications 2016 4:9
  23. Myofibrillar myopathies are characterized by progressive muscle weakness and impressive abnormal protein aggregation in muscle fibers. In about 10 % of patients, the disease is caused by mutations in the MYOT gen...

    Authors: A. Maerkens, M. Olivé, A. Schreiner, S. Feldkirchner, J. Schessl, J. Uszkoreit, K. Barkovits, A. K. Güttsches, V. Theis, M. Eisenacher, M. Tegenthoff, L. G. Goldfarb, R. Schröder, B. Schoser, P. F. M. van der Ven, D. O. Fürst…
    Citation: Acta Neuropathologica Communications 2016 4:8
  24. Like uveal melanomas, primary leptomeningeal melanocytic neoplasms (LMNs) frequently carry GNAQ and GNA11 mutations. However, it is currently unknown whether these LMNs harbor mutations in BAP1, SF3B1 and/or EIF1...

    Authors: Heidi V. N. Küsters-Vandevelde, David Creytens, Adriana C. H. van Engen-van Grunsven, Marcel Jeunink, Veronique Winnepenninckx, Patricia J. T. A. Groenen, Benno Küsters, Pieter Wesseling, Willeke A. M. Blokx and Clemens F. M. Prinsen
    Citation: Acta Neuropathologica Communications 2016 4:5
  25. Glioblastoma with oligodendroglioma component (GBM-O) was recognized as a histologic pattern of glioblastoma (GBM) by the World Health Organization (WHO) in 2007 and is distinguished by the presence of oligode...

    Authors: Benjamin H. Hinrichs, Scott Newman, Christina L. Appin, William Dunn, Lee Cooper, Rini Pauly, Jeanne Kowalski, Michael R. Rossi and Daniel J. Brat
    Citation: Acta Neuropathologica Communications 2016 4:4
  26. Amyotrophic lateral sclerosis (ALS) is a motor neuron disease with a gender bias towards major prevalence in male individuals. Several data suggest the involvement of oxidative stress and mitochondrial dysfunc...

    Authors: Daniel Cacabelos, Omar Ramírez-Núñez, Ana Belén Granado-Serrano, Pascual Torres, Victòria Ayala, Victoria Moiseeva, Mònica Povedano, Isidre Ferrer, Reinald Pamplona, Manuel Portero-Otin and Jordi Boada
    Citation: Acta Neuropathologica Communications 2016 4:3
  27. Diffuse intrinsic pontine glioma (DIPG) and midline high-grade glioma (mHGG) are lethal childhood brain tumors. Spatial genomic heterogeneity has been well-described in adult HGG but has not been comprehensive...

    Authors: Lindsey M. Hoffman, Mariko DeWire, Scott Ryall, Pawel Buczkowicz, James Leach, Lili Miles, Arun Ramani, Michael Brudno, Shiva Senthil Kumar, Rachid Drissi, Phillip Dexheimer, Ralph Salloum, Lionel Chow, Trent Hummel, Charles Stevenson, Q. Richard Lu…
    Citation: Acta Neuropathologica Communications 2016 4:1

    The Erratum to this article has been published in Acta Neuropathologica Communications 2016 4:13

  28. CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) is a hereditary small vessel disease caused by mutations in the NOTCH3 gene, leading to toxic NOTCH3 protein ac...

    Authors: Julie W. Rutten, Roselin R. Klever, Ingrid M. Hegeman, Dana S. Poole, Hans G. Dauwerse, Ludo A. M. Broos, Cor Breukel, Annemieke M. Aartsma-Rus, J. Sjef Verbeek, Louise van der Weerd, Sjoerd G. van Duinen, Arn M. J. M. van den Maagdenberg and Saskia A. J. Lesnik Oberstein
    Citation: Acta Neuropathologica Communications 2015 3:89
  29. Recent advances in molecular diagnostics allow diffuse gliomas to be classified based on their genetic changes into distinct prognostic subtypes. However, a systematic analysis of all molecular markers has thu...

    Authors: Kaspar Draaisma, Maarten M. J. Wijnenga, Bas Weenink, Ya Gao, Marcel Smid, P. Robe, Martin J. van den Bent and Pim J. French
    Citation: Acta Neuropathologica Communications 2015 3:88
  30. The important protective role of small heat-shock proteins (HSPs) in regulating cellular survival and migration, counteracting protein aggregation, preventing apoptosis, and regulating inflammation in the cent...

    Authors: Laura A. N. Peferoen, Wouter H. Gerritsen, Marjolein Breur, Kimberley M. D. Ummenthum, Regina M. B. Peferoen-Baert, Paul van der Valk, Johannes M. van Noort and Sandra Amor
    Citation: Acta Neuropathologica Communications 2015 3:87
  31. Pilocytic astrocytomas are slow-growing tumors that usually occur in the cerebellum or in the midline along the hypothalamic/optic pathways. The most common genetic alterations in pilocytic astrocytomas activa...

    Authors: Tania A. Jones, Jennie N. Jeyapalan, Tim Forshew, Ruth G. Tatevossian, Andrew R. J. Lawson, Sheena N. Patel, Gabriel T. Doctor, Muhammad A. Mumin, Simon R. Picker, Kim P. Phipps, Antony Michalski, Thomas S. Jacques and Denise Sheer
    Citation: Acta Neuropathologica Communications 2015 3:86
  32. Papillary Glioneuronal Tumor (PGNT) is a grade I tumor which was classified as a separate entity in the World Health Organization Classification of the Central Nervous System 2007 in the group of mixed glioneu...

    Authors: Melanie Pages, Ludovic Lacroix, Arnault Tauziede-Espariat, David Castel, Estelle Daudigeos-Dubus, Vita Ridola, Sophie Gilles, Frederic Fina, Felipe Andreiuolo, Marc Polivka, Emmanuele Lechapt-Zalcman, Stephanie Puget, Nathalie Boddaert, Xiao-qiong Liu, Julia A. Bridge, Jacques Grill…
    Citation: Acta Neuropathologica Communications 2015 3:85
  33. The early clinical trials using fetal ventral mesencephalic (VM) allografts in Parkinson’s disease (PD) patients have shown efficacy (albeit not in all cases) and have paved the way for further development of ...

    Authors: Anna Tamburrino, Madeline J. Churchill, Oi W. Wan, Yolanda Colino-Sanguino, Rossana Ippolito, Sofie Bergstrand, Daniel A. Wolf, Niculin J. Herz, Michelle D. Sconce, Anders Björklund, Charles K. Meshul and Mickael Decressac
    Citation: Acta Neuropathologica Communications 2015 3:84
  34. Alzheimer’s disease (AD) is the most dominant neurodegenerative disorder that causes dementia, and no effective treatments are available. To study its pathogenesis and develop therapeutics, animal models repre...

    Authors: James K. Chambers, Takahiko Tokuda, Kazuyuki Uchida, Ryotaro Ishii, Harutsugu Tatebe, Erika Takahashi, Takami Tomiyama, Yumi Une and Hiroyuki Nakayama
    Citation: Acta Neuropathologica Communications 2015 3:78
  35. Authors: Christopher M. Henstridge, Rosemary J. Jackson, JeeSoo M. Kim, Abigail G. Herrmann, Ann K. Wright, Sarah E. Harris, Mark E. Bastin, John M. Starr, Joanna Wardlaw, Thomas H. Gillingwater, Colin Smith, Chris-Anne McKenzie, Simon R. Cox, Ian J. Deary and Tara L. Spires-Jones
    Citation: Acta Neuropathologica Communications 2015 3:83

    The original article was published in Acta Neuropathologica Communications 2015 3:53

  36. Neuromyelitis optica (NMO), an autoimmune astrocytopathic disease associated with anti-aquaporin-4 (AQP4) antibody, is characterized by extensive necrotic lesions preferentially involving the optic nerves and ...

    Authors: Kazuhiro Kurosawa, Tatsuro Misu, Yoshiki Takai, Douglas Kazutoshi Sato, Toshiyuki Takahashi, Yoichiro Abe, Hiroko Iwanari, Ryo Ogawa, Ichiro Nakashima, Kazuo Fujihara, Takao Hamakubo, Masato Yasui and Masashi Aoki
    Citation: Acta Neuropathologica Communications 2015 3:82
  37. Smooth muscle cell contraction is an essential function of arteries and relies on the integrity of the actin-myosin apparatus. The tissue-specific α2-smooth muscle actin, encoded by ACTA2, is predominantly expres...

    Authors: Maria-Magdalena Georgescu, Marco da Cunha Pinho, Timothy E. Richardson, Jose Torrealba, L. Maximilian Buja, Dianna M. Milewicz, Jack M. Raisanen and Dennis K. Burns
    Citation: Acta Neuropathologica Communications 2015 3:81
  38. Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. Immunological studies suggest that it is a T-cell mediated autoimmune disease, although an MS-specific tar...

    Authors: Romana Höftberger, Marianne Leisser, Jan Bauer and Hans Lassmann
    Citation: Acta Neuropathologica Communications 2015 3:80
  39. Demyelinated axons in multiple sclerosis (MS) lesions have an increased energy demand in order to maintain conduction. However, oxidative stress-induced mitochondrial dysfunction likely alters glucose metaboli...

    Authors: Philip G. Nijland, Remco J. Molenaar, Susanne M. A. van der Pol, Paul van der Valk, Cornelis J. F. van Noorden, Helga E. de Vries and Jack van Horssen
    Citation: Acta Neuropathologica Communications 2015 3:79
  40. Depletion of cholinergic neurons within the nucleus basalis of Meynert (nbM) is thought to contribute to the development of cognitive impairments in both Alzheimer’s disease (AD) and Lewy body disorders (LBD)....

    Authors: Athanasios Alexandris, Alan King Lun Liu, Raymond Chuen-Chung Chang, Ronald K. B. Pearce and Steve M. Gentleman
    Citation: Acta Neuropathologica Communications 2015 3:77
  41. Parkinson’s disease (PD) is characterized by the accumulation of abnormal α-synuclein in selected regions of the brain following a gradient of severity with disease progression. Whether this is accompanied by ...

    Authors: Paula Garcia-Esparcia, Karina Hernández-Ortega, Anusha Koneti, Laura Gil, Raul Delgado-Morales, Ester Castaño, Margarita Carmona and Isidre Ferrer
    Citation: Acta Neuropathologica Communications 2015 3:76
  42. Parkinson’s disease (PD) and multiple system atrophy (MSA) are neurodegenerative diseases that are characterized by the intracellular accumulation of alpha-synuclein containing aggregates. Recent increasing ev...

    Authors: Maria E. Bernis, Julius T. Babila, Sara Breid, Katharina Annick Wüsten, Ullrich Wüllner and Gültekin Tamgüney
    Citation: Acta Neuropathologica Communications 2015 3:75
  43. Tamoxifen (TAM) is an important cancer therapeutic and an experimental tool for effecting genetic recombination using the inducible Cre-Lox technique. Despite its widespread use in the clinic and laboratory, w...

    Authors: Franziska Denk, Leanne M. Ramer, Erin L. K. S. Erskine, Mohammed A. Nassar, Yury Bogdanov, Massimo Signore, John N. Wood, Stephen B. McMahon and Matt S. Ramer
    Citation: Acta Neuropathologica Communications 2015 3:74
  44. Autosomal dominant adult-onset neuronal ceroid lipofuscinosis (AD-ANCL) is a multisystem disease caused by mutations in the DNAJC5 gene. DNAJC5 encodes Cysteine String Protein-alpha (CSPα), a putative synaptic pr...

    Authors: Bruno A. Benitez, Nigel J. Cairns, Robert E. Schmidt, John C. Morris, Joanne B. Norton, Carlos Cruchaga and Mark S. Sands
    Citation: Acta Neuropathologica Communications 2015 3:73
  45. Transgenic overexpression of amyloid precursor protein (APP) genes that are either entirely human in sequence or have humanized Aβ sequences can produce Alzheimer-type amyloidosis in mice, provided the transge...

    Authors: Guilian Xu, Yong Ran, Susan E. Fromholt, Chunhua Fu, Anthony T. Yachnis, Todd E. Golde and David R. Borchelt
    Citation: Acta Neuropathologica Communications 2015 3:72
  46. In Alzheimer’s disease, accumulation and pathological aggregation of amyloid β-peptide is accompanied by the induction of complex immune responses, which have been attributed both beneficial and detrimental pr...

    Authors: Claudia Späni, Tobias Suter, Rebecca Derungs, Maria Teresa Ferretti, Tobias Welt, Fabian Wirth, Christoph Gericke, Roger M. Nitsch and Luka Kulic
    Citation: Acta Neuropathologica Communications 2015 3:71

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