Table 1 Clinical and molecular features of embryonal tumors with BRD4-LEUTX fusion
From: Molecular and clinicopathologic characteristics of CNS embryonal tumors with BRD4::LEUTX fusion
Reference case | Age at diagnosis (years), sex | Initial diagnosis | Tumor location | Methylation based classification (v12.b6); score | Fusion (BRD4::LEUTX) |
|---|---|---|---|---|---|
1 BB27 | 1.4, F | Embryonal tumor, favor CNS neuroblastoma FOXR2-activated | Cerebral peduncle/thalamus | CNS Embryonal tumor with BRD4:LEUTX fusion 1.0 | Exons 11:2 |
2 AI01 | 3, M | CNS Embryonal tumor NOS (grade 4) | Interpeduncular | CNS Embryonal tumor with BRD4:LEUTX fusion 1.0 | Exons 14:2 |
3 DQ95 | 1.25, M | Embryonal tumor, favor CNS neuroblastoma FOXR2-activated | Large cystic/solid thalamus | CNS Embryonal tumor with BRD4:LEUTX fusion 0.98 | Exons 11:2 |
4 EV64 | 1, F | Embryonal tumor; Pineoblastoma? | Tectal plate/ third ventricle | CNS Embryonal tumor with BRD4:LEUTX fusion 1.0 | Exons 11:2 |
5 Lebrun | 4, F | Embryonal tumor (NOS) | Left parietal | CNS Embryonal tumor with BRD4:LEUTX fusion 0.99 | Exons 13:2 |
6 Wong | Infant, NA | Embryonal CNS tumor | NA | NA | Exons 11:2 |
7 Northcott (case: SJPB18) | NA | Medulloblastoma | NA; Posterior fossa? | CNS Embryonal tumor with BRD4:LEUTX fusion 0.99 | NA |
8 Capper (case: DIA_0871) | NA | NA | NA | CNS Embryonal tumor with BRD4:LEUTX fusion 0.79 | NA |
9 Tauziede-Espariat (case 3) | 1, M | CNS neuroblastoma FOXR2-activated | Left frontoparietal | CNS Embryonal tumor with BRD4:LEUTX fusion 0.99 | Exons 11:2 |