Table 3 Tumor features of TP53 mutant versus TP53/USP8 wild type and USP8 mutant groups
From: TP53 mutations in functional corticotroph tumors are linked to invasion and worse clinical outcome
Variable | TP53 mutant (n = 9) | TP53/USP8 wild type (n = 52) | P-value | USP8 mutant (n = 25) | P- Valuea | ||||
|---|---|---|---|---|---|---|---|---|---|
Tumor size (mm), median (IQR) | 20.0 | (14.0) | 15.0 | (14.3) | 0.093 | 14.0 | (7.3) | 0.019 | b |
Tumor size, n (%) | 0.184 | 0.289 | |||||||
Microadenoma | 0/9 | (0%) | 13/52 | (25%) | 6/24 | (25%) | |||
Macroadenoma | 9/9 | (100%) | 39/52 | (75%) | 18/24 | (75%) | |||
Invasion, n (%) | 8/8 | (100%) | 19/36 | (53%) | 0.016 | 7/20 | (35%) | 0.006 | b,c |
Hardy grade, n (%) | 0.067 | 0.029 | b | ||||||
1 | 0/8 | (0%) | 7/35 | (20%) | 6/18 | (33%) | |||
2 | 1/8 | (13%) | 13/35 | (37%) | 8/18 | (44%) | |||
3 | 3/8 | (38%) | 11/35 | (31%) | 4/18 | (22%) | |||
4 | 4/8 | (50%) | 4/35 | (11%) | 0/18 | (0%) | |||
Knosp grade, n (%) | 0.016 | 0.011 | b,c | ||||||
0 | 0/7 | (0%) | 2/15 | (13%) | 3/13 | (23%) | |||
1 | 1/7 | (14%) | 6/15 | (40%) | 5/13 | (39%) | |||
2 | 0/7 | (0%) | 1/15 | (7%) | 2/13 | (15%) | |||
3 | 0/7 | (0%) | 4/15 | (27%) | 3/13 | (23%) | |||
4 | 6/7 | (86%) | 2/15 | (13%) | 0/13 | (0%) | |||
Granulation, n (%) | 0.290 | 0.375 | |||||||
Sparsely | 3/5 | (60%) | 4/15 | (27%) | 2/10 | (30%) | |||
Densely | 2/5 | (40%) | 11/15 | (73%) | 8/35 | (70%) | |||
Ki67 index, median (IQR) | 15.0 | (14.8) | 2.0 | (1.0) | 0.006 | 2.5 | (3.8) | 0.009 | c |
Ki67 index ≥ 3%, n (%) | 5/6 | (83%) | 3/18 | (17%) | 0.007 | 6/12 | (50%) | 0.008 | c |
p53 positivity, median (range) | 27.5 | (41.8) | 1.5 | (1.0) | 0.267 | 1.0 | (1.0) | 0.138 | |