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Table 3 Tumor features of TP53 mutant versus TP53/USP8 wild type and USP8 mutant groups

From: TP53 mutations in functional corticotroph tumors are linked to invasion and worse clinical outcome

Variable TP53 mutant
(n = 9)
TP53/USP8 wild type
(n = 52)
P-value USP8 mutant
(n = 25)
  P-
Valuea
 
Tumor size (mm), median (IQR) 20.0 (14.0) 15.0 (14.3) 0.093 14.0 (7.3) 0.019 b
Tumor size, n (%)      0.184    0.289  
 Microadenoma 0/9 (0%) 13/52 (25%)   6/24 (25%)   
 Macroadenoma 9/9 (100%) 39/52 (75%)   18/24 (75%)   
Invasion, n (%) 8/8 (100%) 19/36 (53%) 0.016 7/20 (35%) 0.006 b,c
Hardy grade, n (%)      0.067    0.029 b
 1 0/8 (0%) 7/35 (20%)   6/18 (33%)   
 2 1/8 (13%) 13/35 (37%)   8/18 (44%)   
 3 3/8 (38%) 11/35 (31%)   4/18 (22%)   
 4 4/8 (50%) 4/35 (11%)   0/18 (0%)   
Knosp grade, n (%)      0.016    0.011 b,c
 0 0/7 (0%) 2/15 (13%)   3/13 (23%)   
 1 1/7 (14%) 6/15 (40%)   5/13 (39%)   
 2 0/7 (0%) 1/15 (7%)   2/13 (15%)   
 3 0/7 (0%) 4/15 (27%)   3/13 (23%)   
 4 6/7 (86%) 2/15 (13%)   0/13 (0%)   
Granulation, n (%)      0.290    0.375  
 Sparsely 3/5 (60%) 4/15 (27%)   2/10 (30%)   
Densely 2/5 (40%) 11/15 (73%)   8/35 (70%)   
Ki67 index, median (IQR) 15.0 (14.8) 2.0 (1.0) 0.006 2.5 (3.8) 0.009 c
Ki67 index ≥ 3%, n (%) 5/6 (83%) 3/18 (17%) 0.007 6/12 (50%) 0.008 c
p53 positivity, median (range) 27.5 (41.8) 1.5 (1.0) 0.267 1.0 (1.0) 0.138  
  1. a Adjusted P-value for multiple comparisons (TP53 mutant vs. TP53/USP8 wild type vs. USP8 mutant groups)
  2. b P < 0.05 for TP53 mutant vs. USP8 mutant groups
  3. c P < 0.05 for TP53 mutant vs. TP53/USP8 wild type groups
  4. Bold values indicate P-values < 0.05