Fig. 1

PAS granule density in tauopathy and AD risk mouse models. A Representative immunofluorescent confocal images of 8–11-month-old wild-type control and age matched PS19 hippocampal sections stained with GFAP (red), AT8 (grey), and IgM (green). Nuclei labeled with DAPI. 40 µm thick coronal sections, scale bar = 250 µm. B Comparison of PAS granule density (mm³) in 8–11-month-old wild-type control and age-matched PS19 hippocampal sections. P = 0.0292. C Comparison of GFAP intensity in 8–11-month-old wild-type control and aged matched PS19 hippocampal sections. P = 0.030. D Comparison of AT8 intensity in aged wild-type control and PS19 mice. p = 0.0296. E Representative immunofluorescent images of hippocampal sections from 6-month-old E3 and E4 mice stained with GFAP (red) and IgM (green). Nuclei labeled with DAPI (blue). 40 µm thick coronal sections, scale bar = 20 µm. F Comparison of PAS granule density (mm³) in pooled 6-month-old APOE E2, E3, and E4 mice. *p = 0.0492, **p = 0.0033. G Comparison of PAS granule density (mm³) in male and female 6-month-old APOE E2, E3, and E4 mice. *p = 0.0426 (male), 0.0343 (female)