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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Severe ACTA1-related nemaline myopathy: intranuclear rods, cytoplasmic bodies, and enlarged perinuclear space as characteristic pathological features on muscle biopsies

Fig. 3

Cytoplasmic and intranuclear rods by electron microscopy. Ultrastructural investigations of the muscle biopsy specimens illustrate cytoplasmic rods with the typical lattice structure in patients 4, 6, and 9 (D, E, F), thin filaments emanating from thickened Z-lines in patients 6 and 9 (arrow) (E, F), numerous intranuclear rods in patients 7 (arrow) and 12 (A, B, C), accumulations of thin filaments in patients 7 (arrow) and 13 (H, I), and major myofibre disorganization in patients 4, 7, and 9 (D, G, H). Note the square shape of the intranuclear rods in patient 12 (B, C)

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Acta Neuropathologica Communications

ISSN: 2051-5960

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