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Correction to: Mical modulates Tau toxicity via cysteine oxidation in vivo

The Original Article was published on 04 April 2022

Correction to: Acta Neuropathologica Communications (2022) 10:44 https://doi.org/10.1186/s40478-022-01348-1

Following publication of the original article [1], it was noted that due to a typesetting mistake, incorrect files for Additional files 6 and 7 were processed.

The correct files for Additional files 6 and 7 are attached to this Correction and have been corrected in the original article. The publisher apologises to the authors and readers for the inconvenience caused by this error.

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  1. Prifti et al (2022) Mical modulates Tau toxicity via cysteine oxidation in vivo. Acta Neuropathol Commun 10:44. https://doi.org/10.1186/s40478-022-01348-1

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Correspondence to Katerina Papanikolopoulou.

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Additional file 6: Fig. S5

Targeted proteomics to quantify cysteine oxidation. a Extracted chromatograms for the parent ions and isotopes (upper panel) and of its 6 most abundant fragments (daughter ions, lower panel) at the retention time 27.9 min of the NEM and carbamidomethyl labeled 322CGSLGNIHHKPGGGQVEVK peptide from representative samples of Tau and Tau co-overexpressed with Mical. b Spectra of the scan used for the library creation of the NEM (+ 125 Da) and carbamidomethyl (+ 57 Da) modified 322CGSLGNIHHKPGGGQVEVK peptide.

Additional file 7: Fig. S6 a

Representative Western blot of head lysates from flies expressing UAS-htauFLAG−2N4RC322A using elavC155-GAL4;Ras2-GAL4 and UAS-htauFLAG−2N4RC291A using elavC155-GAL4. Star indicates significant differences between the two groups. b Virgin elavC155-GAL4;Ras2-GAL4 females were crossed with UAS-Mic/CyO and UAS-Mic/CyO;UAS-C322A males. Bars represent the mean number of non-CyO bearing progeny over CyO flies ± SEM of the indicated genotypes. c Response of flies expressing UAS-htauFLAG−2N4RC291A upon treatment with paraquat for 28 h. Star indicates significant difference from the transgene without Mical overexpression. Control flies are elavC155-GAL4/+ (grey bar) and Mical are flies that overexpress Mical under the panneuronal driver (black bar). d Memory performance of animals expressing panneuronally the htauFLAG−2N4RC291A transgene (dark grey bar), compared with the same transgene upon co-expression with Mical (black bar). Star indicates significant difference between the two genotypes. Control flies (light grey bars) are driver elavC155-GAL4/+ flies (CN) and flies that overexpress Mical. The number of experimental replicates (n) is indicated within the bars.

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Prifti, E., Tsakiri, E.N., Vourkou, E. et al. Correction to: Mical modulates Tau toxicity via cysteine oxidation in vivo. acta neuropathol commun 10, 63 (2022). https://doi.org/10.1186/s40478-022-01369-w

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