Fig. 4

Characterization blood-CSF barrier integrity during peripheral immune challenge. a, b Representative images of CP and quantification of the percentage red staining of stained for CDH1, OCLN, CLDN1 and CLDN5. The dotted line indicates the ependymal cells that line the ventricle (n = 4–6). Scale bar: 20 μm. c Expression of the genes Cdh1, Ocln, Cldn1 and Cldn5 in hippocampus (n = 5). Mean ± SEM, two-way ANOVA Bonferroni’s post hoc test for multiple comparisons. *p < 0.05