Fig. 1

LPS induces transient peripheral inflammation and neuroinflammation. a Schematic representation of the experimental design. b Protein levels of IL-1β, TNF and IL-6 in plasma and hippocampus (n = 5–10). c Expression of the pro-inflammatory genes Il1β, Tnf and Il6 in hippocampus (n = 5–10). d Analysis of relative TLR4 activation by plasma and brain lysate (n = 9–21). Mean ± SEM, two-way ANOVA Bonferroni’s post hoc test for multiple comparisons. *p < 0.05, **p < 0.01, ***p < 0.001