Fig. 4

Improvement of spatial learning and memory in neuronal FT knockout APP/PS1 mice. A Path length in the open-field test. B, C Entry to and time spend in the open arms in the elevated plus maze test. * p < 0.05, repeated measures two-way ANOVA with post-hoc Sidak’s multiple comparisons. D Schematic representation of the Morris water maze testing paradigm. E Escape latencies during the acquisition phase of the test. Repeated measures two-way ANOVA with post-hoc Sidak’s multiple comparisons shows a significant interaction between genotype and day during the test (F(4, 90) = 3.188, p = 0.0169), indicating a steeper/faster learning curve in APP/PS1/FTnKO mice; *p < 0.05. F Percentage of time spent in the target quadrant in the probe trial. Time spent in the target quadrant due to chance (25%) is marked with a dashed line. n = 11–13 mice/genotype at 9 months; unpaired Student’s t-test, 1-tailed; *p < 0.05