Perry DC, Sturm VE, Peterson MJ, Pieper CF, Bullock T, Boeve BF et al (2016) Association of traumatic brain injury with subsequent neurological and psychiatric disease: a meta-analysis. J Neurosurg 124(2):511–526
Article
PubMed
Google Scholar
Mackay DF, Russell ER, Stewart K, MacLean JA, Pell JP, Stewart W (2019) Neurodegenerative disease mortality among former professional soccer players. N Engl J Med 381:1801–1808
Article
PubMed
PubMed Central
Google Scholar
Gardner RC, Yaffe K (2015) Epidemiology of mild traumatic brain injury and neurodegenerative disease. Mol Cell Neurosci 66:75–80
Article
CAS
PubMed
PubMed Central
Google Scholar
Nordström A, Nordström P (2018) Traumatic brain injury and the risk of dementia diagnosis: a nationwide cohort study. PLoS Med 15(1):e1002496
Article
PubMed
PubMed Central
Google Scholar
Mez J, Daneshvar DH, Kiernan PT, Abdolmohammadi B, Alvarez VE, Huber BR et al (2017) Clinicopathological evaluation of chronic traumatic encephalopathy in players of American football. JAMA 318(4):360–370
Article
PubMed
PubMed Central
Google Scholar
Gardner RC, Byers AL, Barnes DE, Li Y, Boscardin J, Yaffe K (2018) Mild TBI and risk of parkinson disease: a chronic effects of neurotrauma consortium study. Neurology 90(20):e1771–e1779
Article
PubMed
PubMed Central
Google Scholar
Lehman EJ, Hein MJ, Baron SL, Gersic CM (2012) Neurodegenerative causes of death among retired national football league players. Neurology 79(19):1970–1974
Article
PubMed
PubMed Central
Google Scholar
Crane PK, Gibbons LE, Dams-O’Connor K, Trittschuh E, Leverenz JB, Keene CD et al (2016) Association of traumatic brain injury with late-life neurodegenerative conditions and neuropathologic findings. JAMA Neurol 73(9):1062–1069
Article
PubMed
PubMed Central
Google Scholar
McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR Jr, Kawas CH et al (2011) The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimer’s Dementia 7(3):263–269
Article
PubMed
Google Scholar
Crutch SJ, Schott JM, Rabinovici GD, Murray M, Snowden JS, van der Flier WM et al (2017) Consensus classification of posterior cortical atrophy. Alzheimer’s Dementia 13(8):870–884
Article
PubMed
Google Scholar
Ossenkoppele R, Pijnenburg YA, Perry DC, Cohn-Sheehy BI, Scheltens NM, Vogel JW et al (2015) The behavioural/dysexecutive variant of Alzheimer’s disease: clinical, neuroimaging and pathological features. Brain 138(Pt 9):2732–2749
Article
PubMed
PubMed Central
Google Scholar
Gorno-Tempini ML, Hillis AE, Weintraub S, Kertesz A, Mendez M, Cappa SF et al (2011) Classification of primary progressive aphasia and its variants. Neurology 76(11):1006–1014
Article
PubMed
PubMed Central
Google Scholar
Rascovsky K, Hodges JR, Knopman D, Mendez MF, Kramer JH, Neuhaus J et al (2011) Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain 134(Pt 9):2456–2477
Article
PubMed
PubMed Central
Google Scholar
Weinberger DR, Radulescu E (2021) Structural Magnetic Resonance Imaging All Over Again. JAMA Psychiat 78(1):11–12
Article
Google Scholar
Coughlin JM, Wang Y, Minn I, Bienko N, Ambinder EB, Xu X et al (2017) Imaging of glial cell activation and white matter integrity in brains of active and recently retired national football league players. JAMA Neurol 74(1):67–74
Article
PubMed
PubMed Central
Google Scholar
Montenigro PH, Baugh CM, Daneshvar DH, Mez J, Budson AE, Au R et al (2014) Clinical subtypes of chronic traumatic encephalopathy: literature review and proposed research diagnostic criteria for traumatic encephalopathy syndrome. Alzheimer’s Res Therapy 6(5):68
Article
Google Scholar
Katz DI, Bernick C, Dodick DW, Mez J, Mariani ML, Adler CH, et al (2021) National Institute of neurological disorders and stroke consensus diagnostic criteria for traumatic encephalopathy syndrome, Neurology (Epub Ahead of Print; PMID:33722990)
Iverson GL, Gardner AJ (2020) Risk for misdiagnosing chronic traumatic encephalopathy in men with anger control problems. Front Neurol 11:739
Article
PubMed
PubMed Central
Google Scholar
Iverson GL, Gardner AJ (2020) Risk of misdiagnosing chronic traumatic encephalopathy in men with depression. J Neuropsychiatry Clin Neurosci 32(2):139–146
Article
PubMed
Google Scholar
Koerte IK, Lin AP, Willems A, Muehlmann M, Hufschmidt J, Coleman MJ et al (2015) A review of neuroimaging findings in repetitive brain trauma. Brain Pathol 25(3):318–349
Article
PubMed
PubMed Central
Google Scholar
Ng TS, Lin AP, Koerte IK, Pasternak O, Liao H, Merugumala S et al (2014) Neuroimaging in repetitive brain trauma. Alzheimers Res Ther 6(1):10
Article
PubMed
PubMed Central
Google Scholar
Sundman MH, Hall EE, Chen NK (2014) Examining the relationship between head trauma and neurodegenerative disease: a review of epidemiology, pathology and neuroimaging techniques. J Alzheimer's Dis Parkin 4:137
Google Scholar
Shetty T, Raince A, Manning E, Tsiouris AJ (2016) Imaging in chronic traumatic encephalopathy and traumatic brain injury. Sports Health 8(1):26–36
Article
PubMed
PubMed Central
Google Scholar
Lee BG, Leavitt MJ, Bernick CB, Leger GC, Rabinovici G, Banks SJ (2018) A Systematic review of positron emission tomography of tau, amyloid beta, and neuroinflammation in chronic traumatic encephalopathy: the evidence to date. J Neurotrauma 35(17):2015–2024
Article
PubMed
PubMed Central
Google Scholar
Ayubcha C, Revheim ME, Newberg A, Moghbel M, Rojulpote C, Werner TJ et al (2021) A critical review of radiotracers in the positron emission tomography imaging of traumatic brain injury: FDG, tau, and amyloid imaging in mild traumatic brain injury and chronic traumatic encephalopathy. Eur J Nucl Med Mol Imaging 48(2):623–641
Article
PubMed
Google Scholar
Asken BM, DeKosky ST, Clugston JR, Jaffee MS, Bauer RM (2018) Diffusion tensor imaging (DTI) findings in adult civilian, military, and sport-related mild traumatic brain injury (mTBI): a systematic critical review. Brain Imaging Behav 12(2):585–612
Article
PubMed
Google Scholar
Sparks P, Lawrence T, Hinze S (2020) Neuroimaging in the diagnosis of chronic traumatic encephalopathy: a systematic review. Clin J Sport Med 30(Suppl 1):S1-s10
PubMed
Google Scholar
Dallmeier JD, Meysami S, Merrill DA, Raji CA (2019) Emerging advances of in vivo detection of chronic traumatic encephalopathy and traumatic brain injury. Br J Radiol 92(1101):20180925
Article
PubMed
PubMed Central
Google Scholar
Lin A, Charney M, Shenton ME, Koerte IK (2018) Chronic traumatic encephalopathy: neuroimaging biomarkers. Handb Clin Neurol 158:309–322
Article
PubMed
Google Scholar
Asken BM, Sullan MJ, DeKosky ST, Jaffee MS, Bauer RM (2017) Research gaps and controversies in chronic traumatic encephalopathy: a review. JAMA Neurol 74(10):1255–1262
Article
PubMed
Google Scholar
Bieniek KF, Ross OA, Cormier KA, Walton RL, Soto-Ortolaza A, Johnston AE et al (2015) Chronic traumatic encephalopathy pathology in a neurodegenerative disorders brain bank. Acta Neuropathol 130(6):877–889
Article
CAS
PubMed
PubMed Central
Google Scholar
Alosco ML, Stein TD, Tripodis Y, Chua AS, Kowall NW, Huber BR et al (2019) Association of white matter rarefaction, arteriolosclerosis, and tau with dementia in chronic traumatic encephalopathy. JAMA Neurol 76(11):1298–1308
Article
PubMed
PubMed Central
Google Scholar
Bieniek KF, Cairns NJ, Crary JF, Dickson DW, Folkerth RD, Keene CD et al (2021) The second NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy. J Neuropathol Exp Neurol 80(3):210–219
PubMed
PubMed Central
Google Scholar
McKee AC, Cairns NJ, Dickson DW, Folkerth RD, Keene CD, Litvan I et al (2016) The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy. Acta Neuropathol 131(1):75–86
Article
CAS
PubMed
Google Scholar
Smith DH, Johnson VE, Trojanowski JQ, Stewart W (2019) Chronic traumatic encephalopathy—confusion and controversies. Nature Rev Neurol 15(3):179–183
Article
Google Scholar
Iverson GL, Gardner AJ, Shultz SR, Solomon GS, McCrory P, Zafonte R et al (2019) Chronic traumatic encephalopathy neuropathology might not be inexorably progressive or unique to repetitive neurotrauma. Brain 142(12):3672–3693
Article
PubMed
PubMed Central
Google Scholar
Iverson GL, Luoto TM, Karhunen PJ, Castellani RJ (2019) Mild chronic traumatic encephalopathy neuropathology in people with no known participation in contact sports or history of repetitive neurotrauma. J Neuropathol Exp Neurol 78(7):615–625
Article
CAS
PubMed
PubMed Central
Google Scholar
Gardner RC, Rivera E, O’Grady M, Doherty C, Yaffe K, Corrigan J et al (2020) Screening for lifetime history of traumatic brain injury among older American and Irish adults at risk for dementia: development and validation of a web-based survey. J Alzheimer's Dis 74(2):699–711
Article
Google Scholar
Su E, Bell M (2016) Diffuse axonal injury. In: Laskowitz D, Grant G (eds) Translational research in traumatic brain injury. CRC Press/Taylor and Francis Group © (2016) by Taylor & Francis Group. LLC, Boca Raton, FL, pp 41–84
Google Scholar
Klein AP, Tetzlaff JE, Bonis JM, Nelson LD, Mayer A, Huber DL et al (2019) Prevalence of potentially clinically significant MRI findings in athletes with and without sport-related concussion. J Neurotrauma 36(11):1776–1785
Article
PubMed
PubMed Central
Google Scholar
Champagne AA, Peponoulas E, Terem I, Ross A, Tayebi M, Chen Y et al (2019) Novel strain analysis informs about injury susceptibility of the corpus callosum to repeated impacts. Brain Commun 1(1):fcz021
Article
PubMed
PubMed Central
Google Scholar
Lepage C, Muehlmann M, Tripodis Y, Hufschmidt J, Stamm J, Green K et al (2019) Limbic system structure volumes and associated neurocognitive functioning in former NFL players. Brain Imaging Behav 13(3):725–734
Article
PubMed
PubMed Central
Google Scholar
Lesman-Segev OH, La Joie R, Stephens ML, Sonni I, Tsai R, Bourakova V et al (2019) Tau PET and multimodal brain imaging in patients at risk for chronic traumatic encephalopathy. NeuroImage: Clin 24:102025
Article
Google Scholar
Strain JF, Womack KB, Didehbani N, Spence JS, Conover H, Hart J et al (2015) Imaging correlates of memory and concussion history in retired National Football League athletes. JAMA Neurol 72(7):773–780
Article
PubMed
PubMed Central
Google Scholar
Goswami R, Dufort P, Tartaglia MC, Green RE, Crawley A, Tator CH et al (2016) Frontotemporal correlates of impulsivity and machine learning in retired professional athletes with a history of multiple concussions. Brain Struct Funct 221(4):1911–1925
Article
CAS
PubMed
Google Scholar
Wojtowicz M, Gardner AJ, Stanwell P, Zafonte R, Dickerson BC, Iverson GL (2018) Cortical thickness and subcortical brain volumes in professional rugby league players. NeuroImage Clin 18:377–381
Article
PubMed
PubMed Central
Google Scholar
Misquitta K, Dadar M, Tarazi A, Hussain MW, Alatwi MK, Ebraheem A et al (2018) The relationship between brain atrophy and cognitive-behavioural symptoms in retired Canadian football players with multiple concussions. NeuroImage Clin 19:551–558
Article
PubMed
PubMed Central
Google Scholar
Schultz V, Stern RA, Tripodis Y, Stamm J, Wrobel P, Lepage C et al (2018) Age at first exposure to repetitive head impacts is associated with smaller thalamic volumes in former professional american football players. J Neurotrauma 35(2):278–285
Article
PubMed
PubMed Central
Google Scholar
Lee JK, Wu J, Bullen J, Banks S, Bernick C, Modic MT et al (2020) Association of cavum septum pellucidum and cavum vergae with cognition mood, and brain volumes in professional fighters. JAMA Neurol 77(1):35–42
Article
PubMed
Google Scholar
Zivadinov R, Polak P, Schweser F, Bergsland N, Hagemeier J, Dwyer MG et al (2018) Multimodal imaging of retired professional contact sport athletes does not provide evidence of structural and functional brain damage. J Head Trauma Rehabil 33(5):E24-e32
Article
PubMed
PubMed Central
Google Scholar
Koerte IK, Mayinger M, Muehlmann M, Kaufmann D, Lin AP, Steffinger D et al (2016) Cortical thinning in former professional soccer players. Brain Imaging Behav 10(3):792–798
Article
PubMed
Google Scholar
Broglio SP, McCrea M, McAllister T, Harezlak J, Katz B, Hack D et al (2017) A national study on the effects of concussion in collegiate athletes and US military service academy members: the NCAA-DoD concussion assessment, research and education (CARE) consortium structure and methods. Sports Med 47(7):1437–1451
Article
PubMed
PubMed Central
Google Scholar
Wu YC, Harezlak J, Elsaid NMH, Lin Z, Wen Q, Mustafi SM et al (2020) Longitudinal white-matter abnormalities in sports-related concussion: A diffusion MRI study. Neurology 95(7):e781–e792
Article
PubMed
PubMed Central
Google Scholar
Mustafi SM, Harezlak J, Koch KM, Nencka AS, Meier TB, West JD et al (2018) Acute white-matter abnormalities in sports-related concussion: a diffusion tensor imaging study from the NCAA-DoD CARE consortium. J Neurotrauma 35(22):2653–2664
Article
PubMed
PubMed Central
Google Scholar
Klein AP, Tetzlaff JE, Bonis JM, Nelson LD, Mayer AR, Huber DL et al (2019) Prevalence of potentially clinically significant magnetic resonance imaging findings in athletes with and without sport-related concussion. J Neurotrauma 36(11):1776–1785
Article
PubMed
PubMed Central
Google Scholar
Brett BL, Bobholz SA, España LY, Huber DL, Mayer AR, Harezlak J et al (2020) Cumulative effects of prior concussion and primary sport participation on brain morphometry in collegiate athletes: a study from the NCAA-DoD CARE Consortium. Front Neurol 11:673
Article
PubMed
PubMed Central
Google Scholar
Meier TB, Bellgowan PS, Bergamino M, Ling JM, Mayer AR (2016) Thinner cortex in collegiate football players with, but not without, a self-reported history of concussion. J Neurotrauma 33(4):330–338
Article
PubMed
PubMed Central
Google Scholar
Mills BD, Goubran M, Parivash SN, Dennis EL, Rezaii P, Akers C et al (2020) Longitudinal alteration of cortical thickness and volume in high-impact sports. Neuroimage 217:116864
Article
PubMed
Google Scholar
Wierenga LM, Langen M, Oranje B, Durston S (2014) Unique developmental trajectories of cortical thickness and surface area. Neuroimage 87:120–126
Article
PubMed
Google Scholar
Janssen PH, Mandrekar J, Mielke MM, Ahlskog JE, Boeve BF, Josephs K et al (2017) High school football and late-life risk of neurodegenerative syndromes, 1956–1970. Mayo Clin Proc 92(1):66–71
Article
PubMed
Google Scholar
Savica R, Parisi JE, Wold LE, Josephs KA, Ahlskog JE (2012) High school football and risk of neurodegeneration: a community-based study. Mayo Clin Proc 87(4):335–340
Article
PubMed
PubMed Central
Google Scholar
Deshpande SK, Hasegawa RB, Rabinowitz AR, Whyte J, Roan CL, Tabatabaei A et al (2017) Association of playing high school football with cognition and mental health later in life. JAMA Neurol 74(8):909–918
Article
PubMed
PubMed Central
Google Scholar
Terry DP, Miller LS (2018) Repeated mild traumatic brain injuries is not associated with volumetric differences in former high school football players. Brain Imaging Behav 12(3):631–639
Article
PubMed
Google Scholar
Slobounov SM, Walter A, Breiter HC, Zhu DC, Bai X, Bream T et al (2017) The effect of repetitive subconcussive collisions on brain integrity in collegiate football players over a single football season: a multi-modal neuroimaging study. NeuroImage Clin 14:708–718
Article
PubMed
PubMed Central
Google Scholar
Mayinger MC, Merchant-Borna K, Hufschmidt J, Muehlmann M, Weir IR, Rauchmann BS et al (2018) White matter alterations in college football players: a longitudinal diffusion tensor imaging study. Brain Imaging Behav 12(1):44–53
Article
PubMed
Google Scholar
Gong NJ, Kuzminski S, Clark M, Fraser M, Sundman M, Guskiewicz K et al (2018) Microstructural alterations of cortical and deep gray matter over a season of high school football revealed by diffusion kurtosis imaging. Neurobiol Dis 119:79–87
Article
PubMed
Google Scholar
Murugesan G, Saghafi B, Davenport E, Wagner B, Urban J, Kelley M et al (2018) Single season changes in resting state network power and the connectivity between regions: distinguish head impact exposure level in high school and youth football players. Proc SPIE Int Soc Opt Eng 10575:105750F
PubMed
PubMed Central
Google Scholar
Abbas K, Shenk TE, Poole VN, Breedlove EL, Leverenz LJ, Nauman EA et al (2015) Alteration of default mode network in high school football athletes due to repetitive subconcussive mild traumatic brain injury: a resting-state functional magnetic resonance imaging study. Brain Connect 5(2):91–101
Article
PubMed
Google Scholar
Hirad AA, Bazarian JJ, Merchant-Borna K, Garcea FE, Heilbronner S, Paul D et al (2019) A common neural signature of brain injury in concussion and subconcussion. Sci Adv 5(8):eaau3460
Article
PubMed
PubMed Central
Google Scholar
Davenport ND, Gullickson JT, Grey SF, Hirsch S, Sponheim SR (2018) Longitudinal evaluation of ventricular volume changes associated with mild traumatic brain injury in military service members. Brain Inj 32(10):1245–1255
Article
PubMed
Google Scholar
Bigler ED, Abildskov TJ, Eggleston B, Taylor BA, Tate DF, Petrie JA et al (2019) Structural neuroimaging in mild traumatic brain injury: a chronic effects of neurotrauma consortium study. Int J Methods Psychiat Res 28(3):1781
Article
Google Scholar
Martindale SL, Rostami R, Shura RD, Taber KH, Rowland JA (2020) Brain volume in veterans: relationship to posttraumatic stress disorder and mild traumatic brain injury. J Head Trauma Rehabil 35(4):E330-e341
Article
PubMed
Google Scholar
Stone JR, Avants BB, Tustison NJ, Wassermann EM, Gill J, Polejaeva E et al (2020) Functional and structural neuroimaging correlates of repetitive low-level blast exposure in career breachers. J Neurotrauma 37(23):2468–2481
Article
PubMed
PubMed Central
Google Scholar
Dickstein DL, De Gasperi R, Gama Sosa MA, Perez-Garcia G, Short JA, Sosa H, et al (2020) Brain and blood biomarkers of tauopathy and neuronal injury in humans and rats with neurobehavioral syndromes following blast exposure. Mol Psychiatry (Online ahead of print; PMCID: PMC7484380)
Spillane JD (1962) Five boxers. BMJ 2(5314):1205–1210
Article
CAS
PubMed
PubMed Central
Google Scholar
Mawdsley C, Ferguson FR (1963) Neurological disease in boxers. Lancet (London, England) 2(7312):795–801
Article
CAS
Google Scholar
Gardner RC, Hess CP, Brus-Ramer M, Possin KL, Cohn-Sheehy BI, Kramer JH et al (2016) Cavum septum pellucidum in retired american pro-football players. J Neurotrauma 33(1):157–161
Article
PubMed
PubMed Central
Google Scholar
Koerte IK, Hufschmidt J, Muehlmann M, Tripodis Y, Stamm JM, Pasternak O et al (2016) Cavum septi pellucidi in symptomatic former professional football players. J Neurotrauma 33(4):346–353
Article
PubMed
PubMed Central
Google Scholar
Lee JK, Wu J, Banks S, Bernick C, Massand MG, Modic MT et al (2017) Prevalence of traumatic findings on routine MRI in a large cohort of professional fighters. AJNR Am J Neuroradiol 38(7):1303–1310
Article
CAS
PubMed
PubMed Central
Google Scholar
McKee AC, Stein TD, Nowinski CJ, Stern RA, Daneshvar DH, Alvarez VE et al (2013) The spectrum of disease in chronic traumatic encephalopathy. Brain 136(1):43–64
Article
PubMed
Google Scholar
Smith DH, Johnson VE, Stewart W (2013) Chronic neuropathologies of single and repetitive TBI: substrates of dementia? Nat Rev Neurol 9(4):211–221
Article
CAS
PubMed
PubMed Central
Google Scholar
Wang LX, Li P, He H, Guo F, Tian P, Li C et al (2020) The prevalence of cavum septum pellucidum in mental disorders revealed by MRI: a meta-analysis. J Neuropsychiatry Clin Neurosci 32(2):175–184
Article
PubMed
Google Scholar
Trzesniak C, Oliveira IR, Kempton MJ, Galvão-de Almeida A, Chagas MH, Ferrari MC et al (2011) Are cavum septum pellucidum abnormalities more common in schizophrenia spectrum disorders? A systematic review and meta-analysis. Schizophrenia Res 125(1):1–12
Article
Google Scholar
Hwang J, Kim JE, Kaufman MJ, Renshaw PF, Yoon S, Yurgelun-Todd DA, et al (2013) Enlarged cavum septum pellucidum as a neurodevelopmental marker in adolescent-onset opiate dependence. PLoS One 8(10):e78590.
Chon MW, Choi JS, Kang DH, Jung MH, Kwon JS (2010) MRI study of the cavum septum pellucidum in obsessive-compulsive disorder. Eur Arch Psychiatry Clin Neurosci 260(4):337–343
Article
PubMed
Google Scholar
Kim KJ, Peterson BS (2003) Cavum septi pellucidi in Tourette syndrome. Biol Psychiat 54(1):76–85
Article
PubMed
Google Scholar
Jordan BD, Jahre C, Hauser WA, Zimmerman RD, Zarrelli M, Lipsitz EC et al (1992) CT of 338 active professional boxers. Radiology 185(2):509–512
Article
CAS
PubMed
Google Scholar
Zimmerman RD, Jordan BD (1992) Neuroradiology of boxing injuries. In: Jordan BD (ed) Medical aspects of boxing. CRC Press, Inc., Boca Raton, FL, pp 188–195
Google Scholar
Greer N, Sayer NA, Spoont M, Taylor BC, Ackland PE, MacDonald R et al (2020) Prevalence and severity of psychiatric disorders and suicidal behavior in service members and veterans with and without traumatic brain injury: systematic review. J Head Trauma Rehabil 35(1):1–13
Article
PubMed
Google Scholar
Phipps H, Mondello S, Wilson A, Dittmer T, Rohde NN, Schroeder PJ et al (2020) Characteristics and impact of U.S. military blast-related mild traumatic brain injury: a systematic review. Front Neurol 11:559318
Article
PubMed
PubMed Central
Google Scholar
Molloy C, Conroy RM, Cotter DR, Cannon M (2011) Is traumatic brain injury a risk factor for schizophrenia? A meta-analysis of case-controlled population-based studies. Schizophrenia Bull 37(6):1104–1110
Article
Google Scholar
Jarrett M, Tam R, Hernández-Torres E, Martin N, Perera W, Zhao Y et al (2016) A prospective pilot investigation of brain volume, white matter hyperintensities, and hemorrhagic lesions after mild traumatic brain injury. , Front Neurol 7:11
Article
PubMed
PubMed Central
Google Scholar
Alosco ML, Koerte IK, Tripodis Y, Mariani M, Chua AS, Jarnagin J et al (2018) White matter signal abnormalities in former National Football League players. Alzheimer’s Dementia 10:56–65
Article
PubMed
Google Scholar
Amen DG, Willeumier K, Omalu B, Newberg A, Raghavendra C, Raji CA (2016) Perfusion neuroimaging abnormalities alone distinguish national football league players from a healthy population. J Alzheimer’s Diseas 53(1):237–241
Article
Google Scholar
Roby PR, Duquette P, Kerr ZY, Register-Mihalik J, Stoner L, Mihalik JP (2021) Repetitive head impact exposure and cerebrovascular function in adolescent athletes. J Neurotrauma 38(7):837–847
Article
PubMed
Google Scholar
Hart J, Kraut MA, Womack KB, Strain J, Didehbani N, Bartz E et al (2013) Neuroimaging of cognitive dysfunction and depression in aging retired National Football League players: a cross-sectional study. JAMA Neurol 70(3):326–335
Article
PubMed
PubMed Central
Google Scholar
Bailey DM, Jones DW, Sinnott A, Brugniaux JV, New KJ, Hodson D et al (1979) (2013), Impaired cerebral haemodynamic function associated with chronic traumatic brain injury in professional boxers, Clinical science (London. England 124(3):177–189
Google Scholar
Veksler R, Vazana U, Serlin Y, Prager O, Ofer J, Shemen N et al (2020) Slow blood-to-brain transport underlies enduring barrier dysfunction in American football players. Brain 143(6):1826–1842
Article
PubMed
PubMed Central
Google Scholar
Doherty CP, O’Keefe E, Wallace E, Loftus T, Keaney J, Kealy J et al (2016) Blood-brain barrier dysfunction as a hallmark pathology in chronic traumatic encephalopathy. J Neuropathol Exp Neurol 75(7):656–662
Article
CAS
PubMed
PubMed Central
Google Scholar
Cherry JD, Tripodis Y, Alvarez VE, Huber B, Kiernan PT, Daneshvar DH et al (2016) Microglial neuroinflammation contributes to tau accumulation in chronic traumatic encephalopathy. Acta Neuropathol Commun 4(1):112
Article
PubMed
PubMed Central
CAS
Google Scholar
Hsu ET, Gangolli M, Su S, Holleran L, Stein TD, Alvarez VE et al (2018) Astrocytic degeneration in chronic traumatic encephalopathy. Acta Neuropathol 136(6):955–972
Article
PubMed
Google Scholar
Holleran L, Kim JH, Gangolli M, Stein T, Alvarez V, McKee A et al (2017) Axonal disruption in white matter underlying cortical sulcus tau pathology in chronic traumatic encephalopathy. Acta Neuropathol 133(3):367–380
Article
PubMed
Google Scholar
Provenzano FA, Jordan B, Tikofsky RS, Saxena C, Van Heertum RL, Ichise M (2010) F-18 FDG PET imaging of chronic traumatic brain injury in boxers: a statistical parametric analysis. Nucl Med Commun 31(11):952–957
Article
PubMed
Google Scholar
Bang SA, Song YS, Moon BS, Lee BC, Lee HY, Kim JM et al (2016) Neuropsychological, metabolic, and GABAA receptor studies in subjects with repetitive traumatic brain injury. J Neurotrauma 33(11):1005–1014
Article
PubMed
Google Scholar
Meabon JS, Huber BR, Cross DJ, Richards TL, Minoshima S, Pagulayan KF et al (2016) Repetitive blast exposure in mice and combat veterans causes persistent cerebellar dysfunction. Sci Transl Med 8(321):321ra6
Article
PubMed
CAS
Google Scholar
Mantyh WG, Spina S, Lee A, Iaccarino L, Soleimani-Meigooni D, Tsoy E et al (2020) Tau positron emission tomographic findings in a former US football player with pathologically confirmed chronic traumatic encephalopathy. JAMA Neurol 77(4):517–521
Article
PubMed
PubMed Central
Google Scholar
Rabinovici GD, Gatsonis C, Apgar C, Chaudhary K, Gareen I, Hanna L et al (2019) Association of amyloid positron emission tomography with subsequent change in clinical management among medicare beneficiaries with mild cognitive impairment or dementia. JAMA 321(13):1286–1294
Article
PubMed
PubMed Central
Google Scholar
Stein TD, Montenigro PH, Alvarez VE, Xia W, Crary JF, Tripodis Y et al (2015) Beta-amyloid deposition in chronic traumatic encephalopathy. Acta Neuropathol 130(1):21–34
Article
CAS
PubMed
PubMed Central
Google Scholar
Johnson VE, Stewart W, Smith DH (2012) Widespread tau and amyloid-beta pathology many years after a single traumatic brain injury in humans. Brain Pathol 22(2):142–149
Article
CAS
PubMed
Google Scholar
Johnson VE, Stewart W, Smith DH (2010) Traumatic brain injury and amyloid-β pathology: a link to Alzheimer’s disease? Nat Rev Neurosci 11(5):361
Article
CAS
PubMed
PubMed Central
Google Scholar
Ikonomovic MD, Uryu K, Abrahamson EE, Ciallella JR, Trojanowski JQ, Lee VM et al (2004) Alzheimer’s pathology in human temporal cortex surgically excised after severe brain injury. Exp Neurol 190(1):192–203
Article
CAS
PubMed
Google Scholar
Chen XH, Johnson VE, Uryu K, Trojanowski JQ, Smith DH (2009) A lack of amyloid beta plaques despite persistent accumulation of amyloid beta in axons of long-term survivors of traumatic brain injury. Brain Pathol 19(2):214–223
Article
PubMed
Google Scholar
Hong YT, Veenith T, Dewar D, Outtrim JG, Mani V, Williams C et al (2014) Amyloid imaging with carbon 11–labeled Pittsburgh compound B for traumatic brain injury. JAMA Neurol 71(1):23–31
Article
PubMed
PubMed Central
Google Scholar
Scott G, Ramlackhansingh AF, Edison P, Hellyer P, Cole J, Veronese M et al (2016) Amyloid pathology and axonal injury after brain trauma. Neurology 86(9):821–828
Article
CAS
PubMed
PubMed Central
Google Scholar
Asken BM, Mantyh WG, La Joie R, Strom A, Casaletto KB, Staffaroni AM, et al (2021) Association of remote mild traumatic brain injury with cortical amyloid burden in clinically normal older adults. Brain Imaging Behav (Online ahead of print; PMID:33432536)
Weiner MW, Harvey D, Hayes J, Landau SM, Aisen PS, Petersen RC et al (2017) Effects of traumatic brain injury and posttraumatic stress disorder on development of Alzheimer’s disease in Vietnam veterans using the Alzheimer’s Disease Neuroimaging Initiative: preliminary report. Alzheimer’s Dementia 3(2):177–188
Article
PubMed
PubMed Central
Google Scholar
Sugarman MA, McKee AC, Stein TD, Tripodis Y, Besser LM, Martin B et al (2019) Failure to detect an association between self-reported traumatic brain injury and Alzheimer’s disease neuropathology and dementia. Alzheimer’s Dementia 15(5):686–698
Article
PubMed
Google Scholar
Wang ML, Wei XE, Yu MM, Li PY, Li WB (2017) Self-reported traumatic brain injury and in vivo measure of AD-vulnerable cortical thickness and AD-related biomarkers in the ADNI cohort. Neurosci Lett 655:115–120
Article
CAS
PubMed
Google Scholar
Thompson PW, Ye L, Morgenstern JL, Sue L, Beach TG, Judd DJ et al (2009) Interaction of the amyloid imaging tracer FDDNP with hallmark Alzheimer’s disease pathologies. J Neurochem 109(2):623–630
Article
CAS
PubMed
PubMed Central
Google Scholar
Leung K (2004) 2-(4-(2-[(18)F]Fluoroethyl)piperidin-1-yl)benzo[4,5]imidazo[1,2-a]pyrimidine, Molecular Imaging and Contrast Agent Database (MICAD), National Center for Biotechnology Information (US), Bethesda (MD)
Agdeppa ED, Kepe V, Liu J, Flores-Torres S, Satyamurthy N, Petric A et al (2001) Binding characteristics of radiofluorinated 6-dialkylamino-2-naphthylethylidene derivatives as positron emission tomography imaging probes for beta-amyloid plaques in Alzheimer's disease. J Neurosci 21(24):Rc189
Article
CAS
PubMed
PubMed Central
Google Scholar
Harada R, Okamura N, Furumoto S, Tago T, Yanai K, Arai H et al (2016) Characteristics of tau and its ligands in PET Imaging. Biomolecules 6(1):7
Article
PubMed
PubMed Central
CAS
Google Scholar
Barrio JR, Small GW, Wong KP, Huang SC, Liu J, Merrill DA et al (2015) In vivo characterization of chronic traumatic encephalopathy using [F-18]FDDNP PET brain imaging. Proc Natl Acad Sci USA 112(16):E2039–E2047
Article
CAS
PubMed
PubMed Central
Google Scholar
Omalu B, Small GW, Bailes J, Ercoli LM, Merrill DA, Wong KP et al (2018) Postmortem autopsy-confirmation of antemortem [F-18]FDDNP-PET scans in a football player with chronic traumatic encephalopathy. Neurosurgery 82(2):237–246
Article
PubMed
Google Scholar
Chen ST, Siddarth P, Merrill DA, Martinez J, Emerson ND, Liu J et al (2018) FDDNP-PET tau brain protein binding patterns in military personnel with suspected chronic traumatic encephalopathy1. J Alzheimer’s Disease 65(1):79–88
Article
CAS
Google Scholar
Omalu B, Small G, Bailes J, Ercoli L, Merrill D, Wong K et al (2018) Postmortem autopsy-confirmation of antemortem [F-18] FDDNP-PET scans in a football player with chronic traumatic encephalopathy. Neurosurgery 82:237–246
Article
PubMed
Google Scholar
Soleimani-Meigooni DN, Iaccarino L, La Joie R, Baker S, Bourakova V, Boxer AL et al (2020) 18F-flortaucipir PET to autopsy comparisons in Alzheimer's disease and other neurodegenerative diseases. Brain 143(11):3477–3494
Article
PubMed
PubMed Central
Google Scholar
Ossenkoppele R, Rabinovici GD, Smith R, Cho H, Schöll M, Strandberg O et al (2018) Discriminative accuracy of [18F] flortaucipir positron emission tomography for Alzheimer disease vs other neurodegenerative disorders. JAMA 320(11):1151–1162
Article
CAS
PubMed
PubMed Central
Google Scholar
Lowe VJ, Lundt ES, Albertson SM, Min HK, Fang P, Przybelski SA et al (2020) Tau-positron emission tomography correlates with neuropathology findings. Alzheimer’s Dementia 16(3):561–571
Article
PubMed
Google Scholar
Marquié M, Agüero C, Amaral AC, Villarejo-Galende A, Ramanan P, Chong MST et al (2019) [18 F]-AV-1451 binding profile in chronic traumatic encephalopathy: a postmortem case series. Acta Neuropathol Commun 7(1):164
Article
PubMed
PubMed Central
CAS
Google Scholar
Falcon B, Zivanov J, Zhang W, Murzin AG, Garringer HJ, Vidal R et al (2019) Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules. Nature 568(7752):420
Article
CAS
PubMed
PubMed Central
Google Scholar
Lee CM, Jacobs HIL, Marquié M, Becker JA, Andrea NV, Jin DS et al (2018) 18F-Flortaucipir binding in choroid plexus: related to race and hippocampus signal. J Alzheimer’s Dis 62(4):1691–1702
Article
CAS
Google Scholar
Baker SL, Harrison TM, Maass A, La Joie R, Jagust WJ (2019) Effect of off-target binding on (18)F-flortaucipir variability in healthy controls across the life span. J Nucl Med 60(10):1444–1451
Article
CAS
PubMed
PubMed Central
Google Scholar
Baker SL, Lockhart SN, Price JC, He M, Huesman RH, Schonhaut D et al (2017) Reference Tissue-Based Kinetic Evaluation of 18F-AV-1451 for Tau Imaging, Journal of nuclear medicine : official publication, Society of. Nuclear Medicine 58(2):332–338
Article
CAS
Google Scholar
Johnson KA, Schultz A, Betensky RA, Becker JA, Sepulcre J, Rentz D et al (2016) Tau positron emission tomographic imaging in aging and early Alzheimer disease. Ann Neurol 79(1):110–119
Article
PubMed
Google Scholar
Mitsis EM, Riggio S, Kostakoglu L, Dickstein DL, Machac J, Delman B et al (2014) Tauopathy PET and amyloid PET in the diagnosis of chronic traumatic encephalopathies: studies of a retired NFL player and of a man with FTD and a severe head injury. Transl Psychiatry 4(9):e441
Article
CAS
PubMed
PubMed Central
Google Scholar
Stern RA, Adler CH, Chen K, Navitsky M, Luo J, Dodick DW et al (2019) Tau positron-emission tomography in former national football league players. N Engl J Med 380(18):1716–1725
Article
CAS
PubMed
PubMed Central
Google Scholar
Tanner JA, Rabinovici GD (2021) Relationship between tau and cognition in the evolution of Alzheimer's disease: new insights from tau PET. J Nucl Med 62(5):612–613
Article
PubMed
Google Scholar
Wang YT, Edison P (2019) Tau imaging in neurodegenerative diseases using positron emission tomography. Curr Neurol Neurosci Rep 19(7):45
Article
PubMed
PubMed Central
Google Scholar
Endo H, Shimada H, Sahara N, Ono M, Koga S, Kitamura S et al (2019) In vivo binding of a tau imaging probe, [(11) C]PBB3, in patients with progressive supranuclear palsy. Mov Disord 34(5):744–754
Article
CAS
PubMed
PubMed Central
Google Scholar
Tagai K, Ono M, Kubota M, Kitamura S, Takahata K, Seki C et al (2021) High-contrast in vivo imaging of tau pathologies in Alzheimer's and non-Alzheimer's disease tauopathies. Neuron 109(1):42–58
Article
CAS
PubMed
Google Scholar
Takahata K, Kimura Y, Sahara N, Koga S, Shimada H, Ichise M et al (2019) PET-detectable tau pathology correlates with long-term neuropsychiatric outcomes in patients with traumatic brain injury. Brain 142(10):3265–3279
Article
PubMed
Google Scholar
Aguero C, Dhaynaut M, Normandin MD, Amaral AC, Guehl NJ, Neelamegam R et al (2019) Autoradiography validation of novel tau PET tracer [F-18]-MK-6240 on human postmortem brain tissue. Acta Neuropathol Commun 7(1):37
Article
PubMed
PubMed Central
Google Scholar
Betthauser TJ, Cody KA, Zammit MD, Murali D, Converse AK, Barnhart TE et al (2019) In vivo characterization and quantification of neurofibrillary tau PET radioligand 18F-MK-6240 in humans from Alzheimer disease dementia to young controls. J Nucl Med 60(1):93–99
Article
CAS
PubMed
PubMed Central
Google Scholar
Krishnadas N, Doré V, Lamb F, Groot C, McCrory P, Guzman R et al (2020) Case Report: (18)F-MK6240 tau positron emission tomography pattern resembling chronic traumatic encephalopathy in a retired australian rules football player. Front Neurol 11:
Article
PubMed
PubMed Central
Google Scholar
Cherry JD, Kim SH, Stein TD, Pothast MJ, Nicks R, Meng G et al (2020) Evolution of neuronal and glial tau isoforms in chronic traumatic encephalopathy. Brain pathology (Zurich, Switzerland) 30(5):913–925
Article
CAS
Google Scholar
Arena JD, Smith DH, Lee EB, Gibbons GS, Irwin DJ, Robinson JL et al (2020) Tau immunophenotypes in chronic traumatic encephalopathy recapitulate those of ageing and Alzheimer’s disease. Brain 143(5):1572–1587
Article
PubMed
PubMed Central
Google Scholar
Palleis C, Sauerbeck J, Beyer L, Harris S, Schmitt J, Morenas-Rodriguez E et al (2020) In vivo assessment of neuroinflammation in 4-repeat tauopathies. Mov Disord 36(4):883–894
Article
PubMed
CAS
Google Scholar
Needham EJ, Helmy A, Zanier ER, Jones JL, Coles AJ, Menon DK (2019) The immunological response to traumatic brain injury. J Neuroimmunol 332:112–125
Article
CAS
PubMed
Google Scholar
Kreisl WC, Kim MJ, Coughlin JM, Henter ID, Owen DR, Innis RB (2020) PET imaging of neuroinflammation in neurological disorders. The Lancet Neurology 19(11):940–950
Article
CAS
PubMed
PubMed Central
Google Scholar
Wilson H, Politis M, Rabiner EA, Middleton LT (2020) Novel PET biomarkers to disentangle molecular pathways across age-related neurodegenerative diseases. Cells 9(12):2581
Article
CAS
PubMed Central
Google Scholar
Holland N, Jones PS, Savulich G, Wiggins JK, Hong YT, Fryer TD et al (2020) Synaptic loss in primary tauopathies revealed by [(11) C]UCB-j positron emission tomography. Mov Disord 35(10):1834–1842
Article
CAS
PubMed
PubMed Central
Google Scholar
Mansur A, Rabiner EA, Comley RA, Lewis Y, Middleton LT, Huiban M et al (2020) Characterization of 3 PET tracers for quantification of mitochondrial and synaptic function in healthy human brain: (18)F-BCPP-EF, (11)C-SA-4503, and (11)C-UCB-J. J Nucl Med 61(1):96–103
Article
CAS
PubMed
Google Scholar
Heurling K, Ashton NJ, Leuzy A, Zimmer ER, Blennow K, Zetterberg H et al (2019) Synaptic vesicle protein 2A as a potential biomarker in synaptopathies. Mol Cell Neurosci 97:34–42
Article
CAS
PubMed
Google Scholar
Mecca AP, Chen MK, O’Dell RS, Naganawa M, Toyonaga T, Godek TA et al (2020) In vivo measurement of widespread synaptic loss in Alzheimer’s disease with SV2A PET. Alzheimer’s Dementia 16(7):974–982
Article
PubMed
Google Scholar
Mihalik JP, Amalfe SA, Roby PR, Ford CB, Lynall RC, Riegler KE et al (2020) Sex and sport differences in college lacrosse and soccer head impact biomechanics. Med Sci Sports Exerc 52(11):2349–2356
Article
PubMed
Google Scholar
Reyes J, Mitra B, McIntosh A, Clifton P, Makdissi M, Nguyen JVK et al (2020) An investigation of factors associated with head impact exposure in professional male and female australian football players. Am J Sports Med 48(6):1485–1495
Article
PubMed
Google Scholar
Alsalaheen B, Johns K, Bean R, Almeida A, Eckner J, Lorincz M (2019) Women and men use different strategies to stabilize the head in response to impulsive loads: implications for concussion injury risk. J Orthop Sports Phys Ther 49(11):779–786
Article
PubMed
Google Scholar
Gallagher V, Kramer N, Abbott K, Alexander J, Breiter H, Herrold A et al (2018) The effects of sex differences and hormonal contraception on outcomes after collegiate sports-related concussion. J Neurotrauma 35(11):1242–1247
Article
PubMed
Google Scholar
Dougan BK, Horswill MS, Geffen GM (2014) Athletes’ age, sex, and years of education moderate the acute neuropsychological impact of sports-related concussion: a meta-analysis. J Int Neuropsychol Soc 20(1):64–80
Article
PubMed
Google Scholar
Iverson GL, Gardner AJ, Terry DP, Ponsford JL, Sills AK, Broshek DK et al (2017) Predictors of clinical recovery from concussion: a systematic review. Br J Sports Med 51(12):941–948
Article
PubMed
Google Scholar
Dubal DB (2020) Sex difference in Alzheimer’s disease: An updated, balanced and emerging perspective on differing vulnerabilities. Handb Clin Neurol 175:261–273
Article
PubMed
Google Scholar
Ullah MF, Ahmad A, Bhat SH, Abu-Duhier FM, Barreto GE, Ashraf GM (2019) Impact of sex differences and gender specificity on behavioral characteristics and pathophysiology of neurodegenerative disorders. Neurosci Biobehav Rev 102:95–105
Article
PubMed
Google Scholar
Bernick C, Banks S, Phillips M, Lowe M, Shin W, Obuchowski N et al (2013) Professional fighters brain health study: rationale and methods. Am J Epidemiol 178(2):280–286
Article
PubMed
Google Scholar
Walker WC, Carne W, Franke LM, Nolen T, Dikmen SD, Cifu DX et al (2016) The chronic effects of neurotrauma consortium (CENC) multi-centre observational study: description of study and characteristics of early participants. Brain Inj 30(12):1469–1480
Article
CAS
PubMed
Google Scholar
Yue JK, Vassar MJ, Lingsma HF, Cooper SR, Okonkwo DO, Valadka AB et al (2013) Transforming research and clinical knowledge in traumatic brain injury pilot: multicenter implementation of the common data elements for traumatic brain injury. J Neurotrauma 30(22):1831–1844
Article
PubMed
PubMed Central
Google Scholar
Valera EM, Cao A, Pasternak O, Shenton ME, Kubicki M, Makris N et al (2019) White matter correlates of mild traumatic brain injuries in women subjected to intimate-partner violence: a preliminary study. J Neurotrauma 36(5):661–668
Article
PubMed
PubMed Central
Google Scholar