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Table 3 Surgery finding and inflammatory features of teratomas in patients with anti-NMDARE

From: Co-expression of NMDA-receptor subunits NR1, NR2A, and NR2B in dysplastic neurons of teratomas in patients with paraneoplastic NMDA-receptor-encephalitis: a retrospective clinico-pathology study of 159 patients

Group

Age

Sex

Pathology findings

Location

IgG

CD20

CD138

CD3

CD4

CD8

N1

19

f

2.2 × 4.9 × 5.7 cm Cystic mature teratoma

Left ovary

+

++

+

+

N2

18

f

4.7 × 5 × 6.8cmCystic mature teratoma

thoracic cavity

+++

+++

+++

++

+

N3

17

f

3 × 3 × 2 cm Cystic mature teratoma

Left ovary

++

++

+

+

N4

17

f

Cystic mature teratoma

Right ovary

++

+

++

++

++

N5

28

f

2.1 × 2 × 1.9 cm Cystic mature teratoma

Right ovary

+++

+

N6

20

f

3.7 × 3 × 2.9 cm Cystic mature teratoma

Left ovary

+++

+++

+

N7

22

f

1.5 × 1.2 × 1.6 cm Cystic mature teratoma

Left ovary

++

++

++

N8

20

f

4 × 3 × 1.1 cm Cystic mature teratoma

Left ovary

++

++

+

++

+

N9

29

f

Cystic mature teratoma

Left ovary

+++

+

+

N10

35

f

6.8 × 5.4 × 4.5 cm Immature teratoma (WHO III)

Left ovary

++

++

+

+

N11

43

f

18.5 × 10.3 × 9 cm Immature teratoma (WHO III)

Left ovary

+++

+++

+

+

N12

25

m

6.7 × 5 × 5.4 cm Mixed germ cell tumor (choriocarcinoma with teratoma)

Mediastinum

+++

+++

++

+

+++

+

  1. N, patients with paraneoplastic anti-NMDARE; f female, m male, IgG immunoglobulin, Cellular infiltrates: -, negative or positive cells less than 1% of microscopic field; +, < 25%; ++, 25–50%; +++, 50–75%; ++++, > 75%. positive IgG deposit: -, absent; +, mild; ++, moderate; +++ intense