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Table 1 Clinical data of 12 patients with paraneoplastic anti-NMDA receptor encephalitis

From: Co-expression of NMDA-receptor subunits NR1, NR2A, and NR2B in dysplastic neurons of teratomas in patients with paraneoplastic NMDA-receptor-encephalitis: a retrospective clinico-pathology study of 159 patients

NO Sex/ age Hospital stay/d Prodromal symptom Psychiatric symptoms Seizure Cognitive dysfunction Speech dysfunction Movement disorder Consciousness decreased Autonomic dysfunction Central hypoventilation MRI EEG CSF Anti-NMDAR antibody Immunotherapy mRs of follow-up
CSF Serum
N-1 f/18 57 Headache Early irritability, manic, aggression and automutilation, disorganized, Late Psychomotor inhibition GTCS SE Yes pressured speech and mutism choreoathetoid movements coma hypotension Yes Normal focal slow activity Increased white blood cells +++ ++ IVIG 5d * 2 0 (2.5 Year)
N-2 f/19 106 Fever hallucination, agitation, irritability GTCS Yes pressured speech Orofacial dyskinesia, Myoclonus delirium, light coma pyrexia Yes Bilateral temporal lobe meningeal thickening diffuse slow activity and epileptic activity Increased white blood cells +++ IVIG 5d * 2
Methylprednisolone
0 (4.2 Year)
N-3 f/17 50 Fever Disorganized, agitation, manic, insomnia, hallucinations GTCS Yes No Orofacial dyskinesia coma No No Normal epileptic activity Increased white blood cells ++ +++ IVIG 5d * 2 Methylprednisolone 1000 mg 5d 0 (2.5 Year)
N-4 f/17 73 Have a cold Agitation, Hallucinations, Delusions GTCS Yes No No coma pyrexia, tachycardia Yes meningeal enhancement focal slow activity 0 +++ +++ Methylprednisolone 500 mg 2d
IVIG 20 g 5d*2
0 (5.5 Year)
N-5 f/28 70 No Agitation, Hallucinations, Delusions, automutilation GTCS Yes gibberish-speaking Orofacial dyskinesia, choreoathetoid movements somnolence, deliration No Yes Normal diffuse slow activity and extreme delta brush Increased white blood cells +++ ++ IVIG 5d * 3
Methylprednisolone 1000 mg 3d
1 (1.5 Year)
N-6 f/20 28 Headache Disorganized, agitation CPS Yes No Orofacial dyskinesia light coma tachycardia Yes diffuse slow activity and extreme delta brush Increased white blood cells and Protein +++ _ IVIG 5d * 3
Methylprednisolone 1000 mg 5d
0 (2.4 Year)
N-7 f/22 27 insomnia Agitation, Hallucinations, Delusions, Disorganized, automutilation CPS Yes No Orofacial dyskinesia No urinary incontinence No Normal diffuse slow activity 0 +++ ++ IVIG 5d Methylprednisolone 500 mg 5d 0 (1.6 Year)
N-8 f/20 58 numbness of fingers No SGTCS Yes No finger spasm No No No Normal focal slow activity Increased white blood cells +++ ++ IVIG 5d*2 1 (2 Year)
N-9 f/29 400 Fever Hallucinations GTCS Yes Orofacial dyskinesia coma No Yes Abnormal signals in bilateral frontal and temporal lobe focal slow activity and epileptic activity Elevated pressure and increased white blood cells +++ ++ IVIG 5d * 4 Rituximab 500 mg * 3
Methylprednisolone 1000 mg 5d
1 (1 Year)
N-10 f/35 23 No Aggression, Disorganized, Agitation, Manic, Insomnia, Hallucinations, Psychomotor inhibition CPS SE Yes mutism No coma No Yes cerebral infarction in Splenium of Corpus Callosum, Right lateral ventricle enlargement extreme delta brush 0 +++ ++ IVIG 5d 0 (3.6 Year)
N-11 f/43 15 No Aggression, Disorganized, Agitation, Manic GTCS Yes No No somnolence No No Normal diffuse slow activity and extreme delta brush 0 +++ _ IVIG 5d 0 (2 Year)
N-12 m/25 113 Have a cold Disorganized, Agitation Manic GTCS Yes disfluency Orofacial dyskinesia coma pyrexia Yes Abnormal signals in bilateral temporal lobe and amygdala Normal Elevated pressure and increased white blood cells +++ + IVIG 5d*2 6
  1. f female, m male, GTCS generalized tonic-clonic seizure, SE status epilepticus, CPS complex partial seizure, SGTCS secondary generalized tonic-clonic seizure, negative (−), weakly positive (+, CSF 1:1, serum 1:10), positive (++, CSF 1:10 or 1:32, serum 1:32), strongly positive (+++, CSF 1:100 or 1:320, serum 1:100)