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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Co-expression of NMDA-receptor subunits NR1, NR2A, and NR2B in dysplastic neurons of teratomas in patients with paraneoplastic NMDA-receptor-encephalitis: a retrospective clinico-pathology study of 159 patients

Fig. 2

Pathology findings of neural tissues and NMDAR staining in teratomas without anti-NMDARE. Pathology findings of neural tissues in teratomas and NMDAR staining from patients without anti-NMDARE. (a) HE staining showed neurons with neuropil. (b) a pitch of dysmorphic neurons with enlarged nuclei. (c) Aggregates of neurons positive for MAP2. (d) Neuroglia with moderate positivity for GFAP. (e) Scattered cells with moderate positivity for S100. (f) IgG positivity is moderate and spreading. (g) Plasma cells positive for CD138. (h) and (i) Less positive for CD20 and clusters of lymphocytes positive for CD3. (j) Helper T lymphocytes positive for CD4. (k) Cytotoxic T lymphocytes positive for CD8. (l) isotype control of case C2. (m) scattered dysmorphic neurons positive for NeuN. (n–p) no immunostaining for NR1, NR2A, and NR2B in serial sections of the control case

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Acta Neuropathologica Communications

ISSN: 2051-5960

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