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Table 3 Histologic diagnosis and methylation class (most with low confidence score)

From: Molecular and clinicopathologic features of gliomas harboring NTRK fusions

Case Age (years) Histologic diagnosis NTRK fusion Match to known methylation family? Closest methylation family match Methylation family score
1 24 Low grade glioma NBPF20-NTRK2 No LGG, DNT 0.6959
2 16 Glioma with anaplastic features SPECC1L-NTRK2 No DMG, K27 0.4858
3 0.42 High grade glioma with features of pleomorphic xanthoastrocytoma TRIM24-NTRK2 Yes PXA 0.989
4 6 Low grade glioma GKAP1-NTRK2 No MTGF_PA 0.3584
5 0.23 High grade glioma EML1-NTRK2 No MTGF_PLEX_T 0.4474
6 4 Glioma with anaplastic features ETV6-NTRK3 No MTGF_PLEX_T 0.5473
7 42 Anaplastic ependymoma, WHO grade 3 MYO5A-NTRK3 No MTGF_PLEX_T 0.19
8 42 Glioblastoma, WHO grade 4 CD247-NTRK1 N/A N/A N/A
9 43 Glioblastoma, WHO grade 4 LMNA-NTRK1 No MTGF_GBM 0.6923
10 31 High grade glioma ARHGEF2-NTRK1 No DLGNT 0.2434
11 27 Glioblastoma, WHO grade 4 BCR-NTRK2 N/A N/A N/A
12 38 Anaplastic astrocytoma, WHO grade 3 FRY-NTRK3 No MTGF_PLEX_T 0.4062
13 54 Glioblastoma, WHO grade 4 KIAA1199-NTRK3 N/A N/A N/A
14 0.25 Glioblastoma, WHO grade 4 ETV6-NTRK3 Yes IHG 0.9836
15 2.7 Anaplastic pilocytic astrocytoma KANK1-NTRK2 No PXA 0.7403
16 7 Ganglioglioma, WHO grade 1 KCTD16-NTRK2 No MTGF_PA 0.2699
17 9 Ganglioglioma, WHO grade 1 TRIM24-NTRK2 No MTGF_PA 0.6814
18 16 Diffuse astrocytoma, WHO grade 2 QKI-NTRK2 N/A N/A N/A
19 2 Glioma with anaplastic features TPR and NTRK1 No MTGF_PA 0.3765
20 <1 Glioblastoma, WHO grade 4 ETV6-NTRK3 No MTGF_PLEX_T 0.1241
21 1.83 High grade glioma KIF21B-NTRK1 No MTGF_GBM 0.773
22 7 Glioma with anaplastic features TNS3-NTRK2 No DLGNT 0.6739
23 55 Anaplastic astrocytoma, WHO grade 3 ARGLU1-NTRK1 N/A N/A N/A
24 <1 Glioblastoma, WHO grade 4 NOS1AP-NTRK1 N/A N/A N/A
25 16 Pilocytic astrocytoma, WHO grade 1 AFAP1-NTRK2 N/A N/A N/A
26 26 Diffuse astrocytoma, WHO grade 2 NTRK1-NFASC N/A N/A N/A
27 48 Glioblastoma, WHO grade 4 BCAN-NTRK1 N/A N/A N/A
28 8 Glioblastoma, WHO grade 4 BCR-NTRK2 N/A N/A N/A
29 79 Glioblastoma, WHO grade 4 ARHGEF11-NTRK1 N/A N/A N/A
30 59 Glioblastoma, WHO grade 4 BCAN-NTRK1 N/A N/A N/A
31 54 Glioblastoma, WHO grade 4 BCAN-NTRK1 N/A N/A N/A
32 24 Pilocytic astrocytoma, WHO grade 1 BCAN-NTRK1 N/A N/A N/A
33 3 Desmoplastic infantile ganglioglioma, WHO grade 1 TPM3-NTRK1 N/A N/A N/A
34 52 Glioblastoma, WHO grade 4 DLG1-NTRK3 N/A N/A N/A
35 1 High grade glioma ETV6-NTRK3 N/A N/A N/A
36 <1 Glioblastoma, WHO grade 4 TPM3-NTRK1 N/A N/A N/A
37 63 Glioblastoma, WHO grade 4 TPM3-NTRK1 N/A N/A N/A
38 78 Glioblastoma, WHO grade 4 TPM3-NTRK1 N/A N/A N/A
39 45 Glioblastoma, WHO grade 4 PAIP1-NTRK2 N/A N/A N/A
40 31 Glioblastoma, WHO grade 4 ARHGEF2-NTRK1 N/A N/A N/A
41 81 Glioblastoma, WHO grade 4 LMNA-NTRK1 N/A N/A N/A
42 44 Glioblastoma, WHO grade 4 CHTOP-NTRK1 N/A N/A N/A
  1. N/A Not applicable, LGG, DNT Low-grade glioma, dysembryoplastic neuroepithelial tumor, DMG, K27 Diffuse midline glioma H3 K27M mutant, PXA Pleomorphic xanthoastrocytoma, MTGF_PA Methylation group family_pilocytic astrocytoma, MTGF_PLEX_T Methylation group family_plexus tumor, MTGF_GBM Methylation group family_glioblastoma IDH wildtype, DLGNT Diffuse leptomeningeal glioneuronal tumor, IHG Infantile hemispheric glioma.
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