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Table 3 Histologic diagnosis and methylation class (most with low confidence score)

From: Molecular and clinicopathologic features of gliomas harboring NTRK fusions

Case

Age (years)

Histologic diagnosis

NTRK fusion

Match to known methylation family?

Closest methylation family match

Methylation family score

1

24

Low grade glioma

NBPF20-NTRK2

No

LGG, DNT

0.6959

2

16

Glioma with anaplastic features

SPECC1L-NTRK2

No

DMG, K27

0.4858

3

0.42

High grade glioma with features of pleomorphic xanthoastrocytoma

TRIM24-NTRK2

Yes

PXA

0.989

4

6

Low grade glioma

GKAP1-NTRK2

No

MTGF_PA

0.3584

5

0.23

High grade glioma

EML1-NTRK2

No

MTGF_PLEX_T

0.4474

6

4

Glioma with anaplastic features

ETV6-NTRK3

No

MTGF_PLEX_T

0.5473

7

42

Anaplastic ependymoma, WHO grade 3

MYO5A-NTRK3

No

MTGF_PLEX_T

0.19

8

42

Glioblastoma, WHO grade 4

CD247-NTRK1

N/A

N/A

N/A

9

43

Glioblastoma, WHO grade 4

LMNA-NTRK1

No

MTGF_GBM

0.6923

10

31

High grade glioma

ARHGEF2-NTRK1

No

DLGNT

0.2434

11

27

Glioblastoma, WHO grade 4

BCR-NTRK2

N/A

N/A

N/A

12

38

Anaplastic astrocytoma, WHO grade 3

FRY-NTRK3

No

MTGF_PLEX_T

0.4062

13

54

Glioblastoma, WHO grade 4

KIAA1199-NTRK3

N/A

N/A

N/A

14

0.25

Glioblastoma, WHO grade 4

ETV6-NTRK3

Yes

IHG

0.9836

15

2.7

Anaplastic pilocytic astrocytoma

KANK1-NTRK2

No

PXA

0.7403

16

7

Ganglioglioma, WHO grade 1

KCTD16-NTRK2

No

MTGF_PA

0.2699

17

9

Ganglioglioma, WHO grade 1

TRIM24-NTRK2

No

MTGF_PA

0.6814

18

16

Diffuse astrocytoma, WHO grade 2

QKI-NTRK2

N/A

N/A

N/A

19

2

Glioma with anaplastic features

TPR and NTRK1

No

MTGF_PA

0.3765

20

<1

Glioblastoma, WHO grade 4

ETV6-NTRK3

No

MTGF_PLEX_T

0.1241

21

1.83

High grade glioma

KIF21B-NTRK1

No

MTGF_GBM

0.773

22

7

Glioma with anaplastic features

TNS3-NTRK2

No

DLGNT

0.6739

23

55

Anaplastic astrocytoma, WHO grade 3

ARGLU1-NTRK1

N/A

N/A

N/A

24

<1

Glioblastoma, WHO grade 4

NOS1AP-NTRK1

N/A

N/A

N/A

25

16

Pilocytic astrocytoma, WHO grade 1

AFAP1-NTRK2

N/A

N/A

N/A

26

26

Diffuse astrocytoma, WHO grade 2

NTRK1-NFASC

N/A

N/A

N/A

27

48

Glioblastoma, WHO grade 4

BCAN-NTRK1

N/A

N/A

N/A

28

8

Glioblastoma, WHO grade 4

BCR-NTRK2

N/A

N/A

N/A

29

79

Glioblastoma, WHO grade 4

ARHGEF11-NTRK1

N/A

N/A

N/A

30

59

Glioblastoma, WHO grade 4

BCAN-NTRK1

N/A

N/A

N/A

31

54

Glioblastoma, WHO grade 4

BCAN-NTRK1

N/A

N/A

N/A

32

24

Pilocytic astrocytoma, WHO grade 1

BCAN-NTRK1

N/A

N/A

N/A

33

3

Desmoplastic infantile ganglioglioma, WHO grade 1

TPM3-NTRK1

N/A

N/A

N/A

34

52

Glioblastoma, WHO grade 4

DLG1-NTRK3

N/A

N/A

N/A

35

1

High grade glioma

ETV6-NTRK3

N/A

N/A

N/A

36

<1

Glioblastoma, WHO grade 4

TPM3-NTRK1

N/A

N/A

N/A

37

63

Glioblastoma, WHO grade 4

TPM3-NTRK1

N/A

N/A

N/A

38

78

Glioblastoma, WHO grade 4

TPM3-NTRK1

N/A

N/A

N/A

39

45

Glioblastoma, WHO grade 4

PAIP1-NTRK2

N/A

N/A

N/A

40

31

Glioblastoma, WHO grade 4

ARHGEF2-NTRK1

N/A

N/A

N/A

41

81

Glioblastoma, WHO grade 4

LMNA-NTRK1

N/A

N/A

N/A

42

44

Glioblastoma, WHO grade 4

CHTOP-NTRK1

N/A

N/A

N/A

  1. N/A Not applicable, LGG, DNT Low-grade glioma, dysembryoplastic neuroepithelial tumor, DMG, K27 Diffuse midline glioma H3 K27M mutant, PXA Pleomorphic xanthoastrocytoma, MTGF_PA Methylation group family_pilocytic astrocytoma, MTGF_PLEX_T Methylation group family_plexus tumor, MTGF_GBM Methylation group family_glioblastoma IDH wildtype, DLGNT Diffuse leptomeningeal glioneuronal tumor, IHG Infantile hemispheric glioma.
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Acta Neuropathologica Communications

ISSN: 2051-5960

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