Fig. 3
From: Phosphorylated Aβ peptides in human Down syndrome brain and different Alzheimer’s-like mouse models
pSer8Aβ deposition in TgSwDI mice at different ages in CA1 region and molecular layer of dentate gyrus (DG). Analysis of consecutive sections using npAβ and pSer8Aβ antibodies in TgSwDI mice at 3, 6, 12 and 24 months of age. At 3 months, minute amounts of npAβ and pSer8Aβ reactivity were seen in the subiculum (a, b). At 6 months, deposition of npAβ and pSer8Aβ increased and extended to the CA1 region and dentate gyrus (c, d). By 12 months, both npAβ and pSer8Aβ were increased in the vasculature between the pyramidal neurons and in the stratum oriens (e, f). By 24 months, abundant CAA was observed by intense npAβ immunoreactivity that colocalized almost completely with pSer8Aβ (g, h). Sub, subiculum; Sto, stratum oriens; DG, dentate gyrus; DGm, dentate gyrus molecular layer; DGp, dentate gyrus polymorphic layer; T, thalamus. Scale bar = 200 μm. Enlarged images (insets) in the subiculum and dentate gyrus are indicated by blue and red boxes, respectively. Scale bar = 50 μm