Table 1 Higher abundance proteins enriched at least 1.5x in FXTAS inclusions include protein modifiers, RNA binding proteins, and chaperone proteins

Small ubiquitin-related modifier 2 (SUMO2)

5.5 (0.60/0.11)

60.0 (0.60/0.01)

9.1 (4.37/0.48)

437.0 (4.37/0.01)

p62/ SQSTM1

8.0 (0.08/0.01)

40.0 (0.08/0.002)

30.0 (0.60/0.02)

300.0 (0.60/0.002)

Myeloid leukemia factor 2 (MLF2)

9.3 (0.28/0.03)

93.3 (0.28/0.003)

27.3 (0.82/0.03)

273.3 (0.82/0.003)

Ubiquitin (RS27A)

3.6 (0.65/0.18)

5.9 (0.65/0.11)

6.7 (5.17/0.77)

47.0 (5.17/0.11)

Myelin basic protein (MBP)

3.5 (0.46/0.13)

1.2 (0.46/0.38)

15.2 (0.76/0.05)

2.0 (0.76/0.38)

Heat shock protein HSP 90-alpha (HSP90AA1)

1.6 (0.08/0.05)

4.0 (0.08/0.02)

1.7 (0.67/0.39)

33.5 (0.67/0.02)

Heterogeneous nuclear ribonucleoprotein L (HNRNPL)

1.9 (0.13/0.07)

6.5 (0.13/0.02)

1.6 (0.52/0.32)

26.0 (0.52/0.02)

Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1)

1.7 (1.12/0.65)

2.7 (1.12/0.41)

1.6 (2.16/1.32)

5.3 (2.16/0.41)

Heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3)

1.8 (0.95/0.54)

2.6 (0.95/0.36)

1.6 (1.59/0.97)

4.4 (1.59/0.36)

Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC)

1.9 (0.28/0.15)

1.3 (0.28/0.22)

2.0 (0.59/0.30)

2.7 (0.59/0.22)

Beta-actin (ACTB)

2.2 (0.75/0.34)

1.2 (0.75/0.61)

1.8 (1.33/0.75)

2.2 (1.33/0.61)

Alpha-crystallin B chain (CRYAB)

1.9 (1.29/0.68)

1.1 (1.29/1.22)

1.7 (2.66/1.53)

2.2 (2.66/1.22)

Tubulin alpha-1B chain (TBA1B)

1.6 (1.01/0.63)

1.0 (1.01/0.98)

1.6 (0.81/0.50)

0.8 (0.81/0.98)

Tubulin beta-2A chain (TBB2A)

1.7 (0.64/0.37)

0.9 (0.64/0.71)

1.5 (0.58/0.39)

0.8 (0.58/0.71)

Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2A)

1.7 (0.43/0.25)

0.7 (0.43/0.61)

1.6 (0.59/0.38)

1.0 (0.59/0.61)