Skip to main content

Table 1 Higher abundance proteins enriched at least 1.5x in FXTAS inclusions include protein modifiers, RNA binding proteins, and chaperone proteins

From: Composition of the Intranuclear Inclusions of Fragile X-associated Tremor/Ataxia Syndrome

  FXTAS A Inclusions FXTAS B Inclusions
Proteins Over FXTAS A nuclear Over control nuclear Over FXTAS B nuclear Over control nuclear
Small ubiquitin-related modifier 2 (SUMO2) 5.5 (0.60/0.11) 60.0 (0.60/0.01) 9.1 (4.37/0.48) 437.0 (4.37/0.01)
p62/ SQSTM1 8.0 (0.08/0.01) 40.0 (0.08/0.002) 30.0 (0.60/0.02) 300.0 (0.60/0.002)
Myeloid leukemia factor 2 (MLF2) 9.3 (0.28/0.03) 93.3 (0.28/0.003) 27.3 (0.82/0.03) 273.3 (0.82/0.003)
Ubiquitin (RS27A) 3.6 (0.65/0.18) 5.9 (0.65/0.11) 6.7 (5.17/0.77) 47.0 (5.17/0.11)
Myelin basic protein (MBP) 3.5 (0.46/0.13) 1.2 (0.46/0.38) 15.2 (0.76/0.05) 2.0 (0.76/0.38)
Heat shock protein HSP 90-alpha (HSP90AA1) 1.6 (0.08/0.05) 4.0 (0.08/0.02) 1.7 (0.67/0.39) 33.5 (0.67/0.02)
Heterogeneous nuclear ribonucleoprotein L (HNRNPL) 1.9 (0.13/0.07) 6.5 (0.13/0.02) 1.6 (0.52/0.32) 26.0 (0.52/0.02)
Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) 1.7 (1.12/0.65) 2.7 (1.12/0.41) 1.6 (2.16/1.32) 5.3 (2.16/0.41)
Heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3) 1.8 (0.95/0.54) 2.6 (0.95/0.36) 1.6 (1.59/0.97) 4.4 (1.59/0.36)
Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) 1.9 (0.28/0.15) 1.3 (0.28/0.22) 2.0 (0.59/0.30) 2.7 (0.59/0.22)
Beta-actin (ACTB) 2.2 (0.75/0.34) 1.2 (0.75/0.61) 1.8 (1.33/0.75) 2.2 (1.33/0.61)
Alpha-crystallin B chain (CRYAB) 1.9 (1.29/0.68) 1.1 (1.29/1.22) 1.7 (2.66/1.53) 2.2 (2.66/1.22)
Tubulin alpha-1B chain (TBA1B) 1.6 (1.01/0.63) 1.0 (1.01/0.98) 1.6 (0.81/0.50) 0.8 (0.81/0.98)
Tubulin beta-2A chain (TBB2A) 1.7 (0.64/0.37) 0.9 (0.64/0.71) 1.5 (0.58/0.39) 0.8 (0.58/0.71)
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2A) 1.7 (0.43/0.25) 0.7 (0.43/0.61) 1.6 (0.59/0.38) 1.0 (0.59/0.61)
  1. Only five of these proteins (bolded) were enriched at least 3-fold in FXTAS inclusions over accompanying FXTAS total nuclear proteins, and only SUMO 2/3, MLF2, and p62 were also found to be enriched at least 3-fold in FXTAS total nuclear samples over control total nuclear sample
\