Fig. 8
From: Assembly of transgenic human P301S Tau is necessary for neurodegeneration in murine spinal cord
Heparin-induced assembly of recombinant Tau. a Heparin-induced assembly of recombinant Tau, monitored over time using Thioflavin T fluorescence. P301S Tau is shown in orange, Δ1 in black, Δ2 in red and Δ3 in green. b Coomassie-stained gel of purified proteins. c Negative stain electron microscopy of assembled recombinant Tau. Note that full-length recombinant P301S Tau assembled into filaments, but that Δ1, Δ2, and Δ3 proteins did not form filaments. Scale bars, 200 nm