Fig. 4
From: Transcriptome signatures associated with meningioma progression
New NF2 fusion transcripts identified in meningiomas. a-b Number of fusions transcripts identified through RNA-seq (a) and the significance across grades (b). c, d NF2-ZPBP2 (chromosomes 22q-17q, c) and NF2-OXCT1 (chromosomes 22q-5p, d) fusion transcripts lead to truncated and non-functional NF2 protein. Asterisks mark position of primers used for RT-PCR (e, f) to validate the fusion transcripts. e, f The NF2–ZPBP2 (e) and NF2-OXCT1 (f) fusion transcripts identified by RNA-seq were validated in the corresponding meningioma samples using RT–PCR and Sanger sequencing. All three tumors from patient #4 harbored the fusion NF2-OXCT1 (f)