Area-Gomez E, Schon EA (2017) On the pathogenesis of Alzheimer's disease: the MAM hypothesis. FASEB J 31:864–867. https://doi.org/10.1096/fj.201601309
Article
CAS
PubMed
PubMed Central
Google Scholar
Atluri PP, Ryan TA (2006) The kinetics of synaptic vesicle reacidification at hippocampal nerve terminals. J Neurosci 26:2313–2320. https://doi.org/10.1523/jneurosci.4425-05.2006
Article
CAS
PubMed
Google Scholar
Bae JR, Kim SH (2017) Synapses in neurodegenerative diseases. BMB Rep 50:237–246
Article
CAS
Google Scholar
Brobeil A, Dietel E, Gattenlohner S, Wimmer M (2017) Orchestrating cellular signaling pathways-the cellular “conductor” protein tyrosine phosphatase interacting protein 51 (PTPIP51). Cell Tissue Res 368:411–423. https://doi.org/10.1007/s00441-016-2508-5
Article
CAS
PubMed
Google Scholar
Brobeil A, Viard M, Petri MK, Steger K, Tag C, Wimmer M (2015) Memory and PTPIP51--a new protein in hippocampus and cerebellum. Mol Cell Neurosci 64:61–73. https://doi.org/10.1016/j.mcn.2014.12.003
Article
CAS
PubMed
Google Scholar
Cieri D, Vicario M, Giacomello M, Vallese F, Filadi R, Wagner T, Pozzan T, Pizzo P, Scorrano L, Brini M et al (2018) SPLICS: a split green fluorescent protein-based contact site sensor for narrow and wide heterotypic organelle juxtaposition. Cell Death Differ 25:1131–1145. https://doi.org/10.1038/s41418-017-0033-z
Article
CAS
PubMed
Google Scholar
Csordas G, Weaver D, Hajnoczky G (2018) Endoplasmic reticular-mitochondrial Contactology: structure and signaling functions. Trends Cell Biol 28:523–540. https://doi.org/10.1016/j.tcb.2018.02.009
Article
CAS
PubMed
Google Scholar
DaRocha-Souto B, Coma M, Perez-Nievas BG, Scotton TC, Siao M, Sanchez-Ferrer P, Hashimoto T, Fan Z, Hudry E, Barroeta I et al (2012) Activation of glycogen synthase kinase-3 beta mediates beta-amyloid induced neuritic damage in Alzheimer's disease. Neurobiol Dis 45:425–437. https://doi.org/10.1016/j.nbd.2011.09.002
Article
CAS
PubMed
Google Scholar
De Vos KJ, Morotz GM, Stoica R, Tudor EL, Lau KF, Ackerley S, Warley A, Shaw CE, Miller CCJ (2012) VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis. Hum Mol Genet 21:1299–1311. https://doi.org/10.1093/hmg/ddr559
Article
CAS
PubMed
Google Scholar
Devine MJ, Kittler JT (2018) Mitochondria at the neuronal presynapse in health and disease. Nat Rev Neurosci 19:63–80. https://doi.org/10.1038/nrn.2017.170
Article
CAS
PubMed
Google Scholar
Ferreras S, Fernandez G, Danelon V, Pisano MV, Masseroni L, Chapleau CA, Krapacher FA, Mlewski EC, Masco DH, Arias C et al (2017) Cdk5 Is Essential for Amphetamine to Increase Dendritic Spine Density in Hippocampal Pyramidal Neurons. Front Cell Neurosci 11:372. https://doi.org/10.3389/fncel.2017.00372
Article
CAS
PubMed
PubMed Central
Google Scholar
Filadi R, Theurey P, Pizzo P (2017) The endoplasmic reticulum-mitochondria coupling in heath and disease: molecules, functions and significance. Cell Calcium 62:1–15. https://doi.org/10.1016/j.ceca.2017.01.003
Article
CAS
PubMed
Google Scholar
Gomez-Suaga P, Paillusson S, Stoica R, Noble W, Hanger DP, Miller CC (2017) The ER-mitochondria tethering complex VAPB-PTPIP51 regulates autophagy. Curr Biol 27:371–385. https://doi.org/10.1016/j.cub.2016.12.038
Article
CAS
PubMed
PubMed Central
Google Scholar
Griffiths EJ, Rutter GA (2009) Mitochondrial calcium as a key regulator of mitochondrial ATP production in mammalian cells. Biochim Biophys Acta 1787:1324–1333. https://doi.org/10.1016/j.bbabio.2009.01.019
Article
CAS
PubMed
Google Scholar
Gutierrez T, Simmen T (2018) Endoplasmic reticulum chaperones tweak the mitochondrial calcium rheostat to control metabolism and cell death. Cell Calcium 70:64–75. https://doi.org/10.1016/j.ceca.2017.05.015
Article
CAS
PubMed
Google Scholar
Hedskog L, Pinho CM, Filadi R, Ronnback A, Hertwig L, Wiehager B, Larssen P, Gellhaar S, Sandebring A, Westerlund M et al (2013) Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer's disease and related models. Proc Natl Acad Sci USA 110:7916–7921. https://doi.org/10.1073/pnas.1300677110
Article
PubMed
Google Scholar
Herms J, Dorostkar MM (2016) Dendritic spine pathology in neurodegenerative diseases. Annu Rev Pathol 11:221–250. https://doi.org/10.1146/annurev-pathol-012615-044216
Article
CAS
PubMed
Google Scholar
Hirabayashi Y, Kwon SK, Paek H, Pernice WM, Paul MA, Lee J, Erfani P, Raczkowski A, Petrey DS, al PLA (2017) ER-mitochondria tethering by PDZD8 regulates Ca2+ dynamics in mammalian neurons. Science (New York, NY) 358:623–630. https://doi.org/10.1126/science.aan6009
Article
CAS
Google Scholar
Iwabuchi S, Kakazu Y, Koh JY, Goodman KM, Harata NC (2014) Examination of synaptic vesicle recycling using FM dyes during evoked, spontaneous, and miniature synaptic activities. J Vis Exp: Doi. https://doi.org/10.3791/50557
Jackson RE, Burrone J (2016) Visualizing presynaptic calcium dynamics and vesicle fusion with a single genetically encoded reporter at individual synapses. Front Synaptic Neurosci 8:21. https://doi.org/10.3389/fnsyn.2016.00021
Article
CAS
PubMed
PubMed Central
Google Scholar
Kasai H, Fukuda M, Watanabe S, Hayashi-Takagi A, Noguchi J (2010) Structural dynamics of dendritic spines in memory and cognition. Trends Neurosci 33:121–129. https://doi.org/10.1016/j.tins.2010.01.001
Article
CAS
PubMed
Google Scholar
Kim JY, Jang A, Reddy R, Yoon WH, Jankowsky JL (2016) Neuronal overexpression of human VAPB slows motor impairment and neuromuscular denervation in a mouse model of ALS. Hum Mol Genet 25:4661–4673. https://doi.org/10.1093/hmg/ddw294
Article
CAS
PubMed
PubMed Central
Google Scholar
Krols M, van Isterdael G, Asselbergh B, Kremer A, Lippens S, Timmerman V, Janssens S (2016) Mitochondria-associated membranes as hubs for neurodegeneration. Acta Neuropathol 131:505–523. https://doi.org/10.1007/s00401-015-1528-7
Article
CAS
PubMed
PubMed Central
Google Scholar
Lau DHW, Hartopp N, Welsh NJ, Mueller S, Glennon EB, Morotz GM, Annibali A, Gomez-Suaga P, Stoica R, Paillusson S et al (2018) Disruption of ER-mitochondria signalling in fronto-temporal dementia and related amyotrophic lateral sclerosis. Cell Death Disease 9:327. https://doi.org/10.1038/s41419-017-0022-7
Article
CAS
PubMed
PubMed Central
Google Scholar
Laughlin SB, de Ruyter van Steveninck RR, Anderson JC (1998) The metabolic cost of neural information. Nat Neurosci 1:36–41. https://doi.org/10.1038/236.
Article
CAS
Google Scholar
Lauwers E, Goodchild R, Verstreken P (2016) Membrane lipids in presynaptic function and disease. Neuron 90:11–25. https://doi.org/10.1016/j.neuron.2016.02.033
Article
CAS
PubMed
Google Scholar
Lazarenko RM, DelBove CE, Zhang Q (2018) Fluorescent measurement of synaptic activity using FM dyes in dissociated hippocampal cultured neurons. Bio Protoc 8. https://doi.org/10.21769/BioProtoc.2690
Ling SC, Polymenidou M, Cleveland DW (2013) Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis. Neuron 79:416–438. https://doi.org/10.1016/j.neuron.2013.07.033
Article
CAS
PubMed
PubMed Central
Google Scholar
Mao LM, Wang JQ (2016) Synaptically localized mitogen-activated protein kinases: local substrates and regulation. Mol Neurobiol 53:6309–6315. https://doi.org/10.1007/s12035-015-9535-1
Article
CAS
PubMed
Google Scholar
Micheva KD, Taylor CP, Smith SJ (2006) Pregabalin reduces the release of synaptic vesicles from cultured hippocampal neurons. Mol Pharmacol 70:467–476. https://doi.org/10.1124/mol.106.023309
Article
CAS
PubMed
Google Scholar
Mironov SL, Symonchuk N (2006) ER vesicles and mitochondria move and communicate at synapses. J Cell Sci 119:4926–4934
Article
CAS
Google Scholar
Nikoletopoulou V, Tavernarakis N (2018) Regulation and roles of autophagy at synapses. Trends Cell Biol 28:646–661. https://doi.org/10.1016/j.tcb.2018.03.006
Article
CAS
PubMed
Google Scholar
Paillusson S, Gomez-Suaga P, Stoica R, Little D, Gissen P, Devine MJ, Noble W, Hanger DP, Miller CC (2017) Alpha-Synuclein binds to the ER-mitochondria tethering protein VAPB to disrupt Ca2+ homeostasis and mitochondrial ATP production. Acta Neuropathol 134:129–149. https://doi.org/10.1007/s00401-017-1704-z
Article
CAS
PubMed
PubMed Central
Google Scholar
Paillusson S, Stoica R, Gomez-Suaga P, Lau DH, Mueller S, Miller T, Miller CC (2016) There's something wrong with my MAM; the ER-mitochondria axis and neurodegenerative diseases. Trends Neurosci 39:146–157. https://doi.org/10.1016/j.tins.2016.01.008
Article
CAS
PubMed
PubMed Central
Google Scholar
Perez-Nievas BG, Stein TD, Tai HC, Dols-Icardo O, Scotton TC, Barroeta-Espar I, Fernandez-Carballo L, de Munain EL, Perez J, Marquie M et al (2013) Dissecting phenotypic traits linked to human resilience to Alzheimer's pathology. Brain 136:2510–2526. https://doi.org/10.1093/brain/awt171
Article
PubMed
PubMed Central
Google Scholar
Pickett EK, Koffie RM, Wegmann S, Henstridge CM, Herrmann AG, Colom-Cadena M, Lleo A, Kay KR, Vaught M, Soberman R et al (2016) Non-Fibrillar oligomeric amyloid-beta within synapses. J Alzheimers Dis 53:787–800. https://doi.org/10.3233/jad-160007
Article
CAS
PubMed
Google Scholar
Rieusset J (2018) Mitochondria-associated membranes (MAMs): an emerging platform connecting energy and immune sensing to metabolic flexibility. Biochem Biophys Res Commun 500:35–44. https://doi.org/10.1016/j.bbrc.2017.06.097
Article
CAS
PubMed
Google Scholar
Rother M, Brauner JM, Ebert K, Welzel O, Jung J, Bauereiss A, Kornhuber J, Groemer TW (2014) Dynamic properties of the alkaline vesicle population at hippocampal synapses. PLoS One 9:e102723. https://doi.org/10.1371/journal.pone.0102723
Article
CAS
PubMed
PubMed Central
Google Scholar
Rowland AA, Voeltz GK (2012) Endoplasmic reticulum-mitochondria contacts: function of the junction. Nat Rev Mol Cell Biol 13:607–625. https://doi.org/10.1038/nrm3440
Article
CAS
PubMed
PubMed Central
Google Scholar
Segal M (2005) Dendritic spines and long-term plasticity. Nat Rev Neurosci 6:277–284. https://doi.org/10.1038/nrn1649
Article
CAS
PubMed
Google Scholar
Sjostrom PJ, Rancz EA, Roth A, Hausser M (2008) Dendritic excitability and synaptic plasticity. Physiol Rev 88:769–840. https://doi.org/10.1152/physrev.00016.2007
Article
CAS
PubMed
Google Scholar
Soderberg O, Gullberg M, Jarvius M, Ridderstrale K, Leuchowius KJ, Jarvius J, Wester K, Hydbring P, Bahram F, al LLG (2006) Direct observation of individual endogenous protein complexes in situ by proximity ligation. Nat Methods 3:995–1000. https://doi.org/10.1038/nmeth947
Article
CAS
PubMed
Google Scholar
Spires-Jones TL, Attems J, Thal DR (2017) Interactions of pathological proteins in neurodegenerative diseases. Acta Neuropathol 134:187–205. https://doi.org/10.1007/s00401-017-1709-7
Article
CAS
PubMed
PubMed Central
Google Scholar
Spruston N (2008) Pyramidal neurons: dendritic structure and synaptic integration. Nat Rev Neurosci 9:206–221. https://doi.org/10.1038/nrn2286
Article
CAS
PubMed
Google Scholar
Stoica R, De Vos KJ, Paillusson S, Mueller S, Sancho RM, Lau KF, Vizcay-Barrena G, Lin WL, Xu YF, Lewis J et al (2014) ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43. Nat Commun 5:3996. https://doi.org/10.1038/ncomms4996
Article
CAS
PubMed
PubMed Central
Google Scholar
Stoica R, Paillusson S, Gomez-Suaga P, Mitchell JC, Lau DH, Gray EH, Sancho RM, Vizcay-Barrena G, De Vos KJ, Shaw CE et al (2016) ALS/FTD-associated FUS activates GSK-3beta to disrupt the VAPB-PTPIP51 interaction and ER-mitochondria associations. EMBO Rep 17:1326–1342. https://doi.org/10.15252/embr.201541726
Article
CAS
PubMed
PubMed Central
Google Scholar
Tai HC, Serrano-Pozo A, Hashimoto T, Frosch MP, Spires-Jones TL, Hyman BT (2012) The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system. Am J Pathol 181:1426–1435. https://doi.org/10.1016/j.ajpath.2012.06.033
Article
CAS
PubMed
PubMed Central
Google Scholar
Tyler WJ, Zhang XL, Hartman K, Winterer J, Muller W, Stanton PK, Pozzo-Miller L (2006) BDNF increases release probability and the size of a rapidly recycling vesicle pool within rat hippocampal excitatory synapses. J Physiol 574:787–803. https://doi.org/10.1113/jphysiol.2006.111310
Article
CAS
PubMed
PubMed Central
Google Scholar
Vlachos A, Korkotian E, Schonfeld E, Copanaki E, Deller T, Segal M (2009) Synaptopodin regulates plasticity of dendritic spines in hippocampal neurons. J Neurosci 29:1017–1033. https://doi.org/10.1523/jneurosci.5528-08.2009
Article
CAS
PubMed
Google Scholar
Wu Y, Whiteus C, Xu CS, Hayworth KJ, Weinberg RJ, Hess HF, De Camilli P (2017) Contacts between the endoplasmic reticulum and other membranes in neurons. Proc Natl Acad Sci U S A 114:E4859–E4867. https://doi.org/10.1073/pnas.1701078114
Article
CAS
PubMed
PubMed Central
Google Scholar