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Table 2 Proteins in the cerebral blood vessels of CAA patients vs. non-CAA patients

From: Apolipoprotein E and clusterin inhibit the early phase of amyloid-β aggregation in an in vitro model of cerebral amyloid angiopathy

Accession number Protein CAA (n = 6)a Non-CAA (n = 5) a p value*
% Detection NSAFCAA % Detection NSAFnon-CAA
P02649 Apolipoprotein E 100 0.1259 20 0.0006 0.004
P05067 Amyloid beta A4 protein 100 0.0685 0 ND 0.004
P10909 Clusterin 100 0.039 20 0.0015 0.004
P02768 Serum albumin 100 0.046 100 0.0154 0.017
P08123 Collagen alpha-2(I) chain 100 0.0031 80 0.0019 0.329
P68871 Hemoglobin subunit beta 100 0.1695 100 0.249 0.662
P69905 Hemoglobin subunit alpha 100 0.0778 100 0.0718 0.792
P04004 Vitronectin 83 0.0085 20 0.0004 0.03
P0C0L4 Complement C4-A 83 0.0032 20 0.0001 0.03
P08670 Vimentin 83 0.0207 80 0.0159 0.247
P41222 Prostaglandin-H2 D-isomerase 67 0.013 40 0.0021 0.177
Q15149 Plectin 67 0.0006 40 0.0001 0.177
Q8IYA6 Cytoskeleton-associated protein 2-like 67 0.0147 80 0.006 0.537
P06727 Apolipoprotein A-IV 50 0.0096 0 ND 0.177
Q70EL1 Inactive ubiquitin carboxyl-terminal hydrolase 54 50 0.0035 0 ND 0.177
P11047 Laminin subunit gamma-1 50 0.0014 0 ND 0.177
P02042 Hemoglobin subunit delta 50 0.0313 80 0.0735 0.247
Q8N413 Solute carrier family 25 member 45 50 0.0102 20 0.0011 0.329
P35625 Metalloproteinase inhibitor 3 50 0.0084 20 0.0009 0.329
P07437 Tubulin beta chain 50 0.0061 40 0.0018 0.429
P12814 Alpha-actinin-1 50 0.0015 40 0.0005 0.429
P14136 Glial fibrillary acidic protein 50 0.0265 60 0.0116 0.662
Q9BQE3 Tubulin alpha-1C chain 50 0.0051 60 0.0018 0.662
A6NNT2 Putative uncharacterized protein C16orf96 50 0.004 60 0.0011 0.662
P04350 Tubulin beta-4A chain 50 0.0064 80 0.0045 0.792
P98160 Basement membrane-specific heparan sulfate proteoglycan core protein 50 0.0004 60 0.0004 1
  1. Proteins which show the % detection to be ≥50% in CAA patients are listed. % Detection means the relative number of patients positive for each protein in both CAA and non-CAA patients
  2. ND not detected
  3. *The Mann-Whitney U test was used for comparisons between NSAFCAA and NSAFnon-CAA values
  4. aProtein abundance values were estimated using NSAF (normalized spectral abundance factor) normalizaiton
  5. Boldface highlights the proteins which were significantly upregulated in the cerebral blood vessels of CAA patients as compared to non-CAA patients