Fig. 5
From: Preventive action of benztropine on platinum-induced peripheral neuropathies and tumor growth
In vitro effects of oxaliplatin, associated or not with benztropine, on excitability of mouse DRG sensory neurons, using whole-cell patch-clamp technique. Resting membrane potential (a), and action potential peak amplitude (b), rise time (c) and decay time (d) measured from recordings performed on DRG neurons before (control) and 10–20 min after addition of first 25–50 μM oxaliplatin (O) and then 25–50 μM oxaliplatin plus 10 μM benztropine (B) to the standard physiological medium. Mean ± SD of 5–18 neurons. *p = 0.010–0.014, **p = 0.002–0.005 and ***p < 0.001 versus control