Table 3 A, B and C Proteins identified as selectively altered in CAA type-1
Gene | Protein | P-val C vs CAA | P-val AD vs CAA | FDR C vs CAA | FDR AD vs CAA | FC C vs CAA | FC AD vs CAA | # detections Control | # detections AD | # detections CAA |
|---|---|---|---|---|---|---|---|---|---|---|
A. Significant CAA versus control and CAA versus Alzheimer's disease | ||||||||||
CLU | Clusterin;Clusterin beta chain;Clusterin alpha chain | 0.000 | 0.000 | 0.001 | 0.007 | 4.47 | 2.33 | 6 | 7 | 7 |
APOE | Apolipoprotein E | 0.001 | 0.001 | ns | ns | 4.97 | 2.11 | 6 | 7 | 7 |
SUCLG2 | Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial | 0.002 | 0.002 | ns | ns | 2.17 | 0.61 | 5 | 7 | 7 |
PPP2R4 | Serine/threonine-protein phosphatase 2A activator | 0.026 | 0.010 | ns | ns | 2.18 | 0.80 | 6 | 7 | 7 |
KTN1 | Kinectin | 0.015 | 0.021 | ns | ns | 0.34 | 0.40 | 2 | 2 | 3 |
ACTG1 | Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed | 0.000 | 0.035 | ns | ns | 0.80 | 0.90 | 6 | 7 | 7 |
TNR | Tenascin-R | 0.007 | 0.017 | ns | ns | 0.82 | 0.82 | 6 | 7 | 7 |
COL6A3 | Collagen alpha-3(VI) chain | 0.016 | 0.024 | ns | ns | 7.79 | 4.95 | 3 | 5 | 7 |
NFASC | Neurofascin | 0.028 | 0.040 | ns | ns | 0.86 | 0.87 | 6 | 7 | 7 |
B. Significant CAA versus control or Alzheimer’s disease and ≤1 detection in other group | ||||||||||
APP | Amyloid beta A4 protein;N-APP;Soluble APP-alpha;Soluble APP-beta; | NA | 0.000 | NA | ns | NA | 6.65 | 1 | 7 | 7 |
UBLCP1 | Ubiquitin-like domain-containing CTD phosphatase 1 | NA | 0.007 | NA | ns | NA | 1.96 | 1 | 2 | 4 |
SRI | Sorcin | NA | 0.011 | NA | ns | NA | 0.25 | 1 | 3 | 5 |
NDP | Norrin | NA | 0.020 | NA | ns | NA | 5.16 | 0 | 4 | 7 |
PNP | Purine nucleoside phosphorylase | NA | 0.030 | NA | ns | NA | 1.72 | 0 | 3 | 3 |
C1orf123 | UPF0587 protein C1orf123 | NA | 0.047 | NA | ns | NA | 0.71 | 0 | 6 | 6 |
DHX15 | Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 | 0.005 | NA | ns | NA | 0.44 | NA | 3 | 0 | 5 |
SYNPO | Synaptopodin | 0.015 | NA | ns | NA | 0.44 | NA | 4 | 1 | 4 |
TPM1 | Tropomyosin alpha-1 chain | 0.021 | NA | ns | NA | 0.37 | NA | 3 | 1 | 3 |
CADPS2 | Calcium-dependent secretion activator 2 | 0.042 | NA | ns | NA | 1.22 | NA | 2 | 1 | 3 |
SERPINA3 | Alpha-1-antichymotrypsin;Alpha-1-antichymotrypsin His-Pro-less | 0.042 | NA | ns | NA | −0.86 | NA | 2 | 1 | 3 |
C. ≤1 detection in control and Alzheimer's disease and ≥4 in CAA OR ≤1 in CAA and ≥4 in Alzheimer’s disease and control | ||||||||||
HLA-DRA;HLA-DQA2 | HLA class II histocompatibility antigen, DR alpha chain;HLA class II histocompatibility antigen, DQ alpha 2 chain | NA | NA | NA | NA | NA | NA | 0 | 1 | 7 |
HTRA1 | Serine protease HTRA1 | NA | NA | NA | NA | NA | NA | 0 | 1 | 7 |
APCS | Serum amyloid P-component;Serum amyloid P-component(1–203) | NA | NA | NA | NA | NA | NA | 0 | 1 | 6 |
COL6A2 | Collagen alpha-2(VI) chain | NA | NA | NA | NA | NA | NA | 0 | 1 | 5 |
MOB2 | MOB kinase activator 2 | NA | NA | NA | NA | NA | NA | 1 | 1 | 5 |
POTEI | POTE ankyrin domain family member I | NA | NA | NA | NA | NA | NA | 1 | 0 | 4 |
KIAA1468 | LisH domain and HEAT repeat-containing protein KIAA1468 | NA | NA | NA | NA | NA | NA | 1 | 0 | 4 |
TMF1 | TATA element modulatory factor | NA | NA | NA | NA | NA | NA | 0 | 1 | 4 |
SGIP1 | SH3-containing GRB2-like protein 3-interacting protein 1 | NA | NA | NA | NA | NA | NA | 4 | 4 | 1 |