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Table 4 Pairwise comparisons among cohorts for each of the vascular outcome measures. The odds ratio (OR) of a higher-level finding was compared among cohorts. Estimated odds used cumulative logistic regression to model the chance of higher-versus-lower severity outcome based on an indicator of the cohort. For arteriolosclerosis, only the AD versus Ctrl comparison could be reliably estimated

From: Cerebrovascular pathology in Down syndrome and Alzheimer disease

Odds Ratios (OR) among Cohorts
Vascular finding Est. (95% CI) P-value df
Atherosclerosis
 AD vs Ctrl 0.46 (0.22, 0.95) 0.0353 140
 AD vs Ctrl 0.46 (0.22, 0.95) 0.0353 140
 DS vs Ctrl 0.11 (0.04, 0.30) < 0.0001 140
 DS vs AD 0.23 (0.09, 0.59) 0.0026 140
Arteriolosclerosis
 AD vs Ctrl 1.08 (0.51, 2.32) 0.8376 142
CAA
 AD vs Ctrl 10.12 (3.94, 25.96) < 0.0001 142
 DS vs Ctrl 30.88 (10.15, 93.99) < 0.0001 142
 DS vs AD 3.05 (1.40, 6.67) 0.0055 142