Fig. 1

a, b K and Rb levels in fractionated brain homogenates were consistently decreased in AD brains (n = 30 per group; one-way ANOVA; ** p < 0.01; *** p < 0.001; percentage decrease in AD group compared to healthy controls shown). Error bars represent the standard error of the mean. c Both metals showed significant correlation regardless of clinical classification (p < 0.001), though the slope of the line of best fit was significantly decreased in the AD group (p < 0.05). d, e Both metals performed well at predicting AD via ROC curve analysis, with Rb slightly superior performance