|
Mouse line
|
Bioassay parameters
|
Inoculum
|
|---|
|
100% scrapie
|
1% BSE
|
2% BSE
|
10% BSE
|
50% BSE
|
100% BSE
|
|---|
|
RIII
|
AR
|
0.95
|
0.95
|
0.80
|
0.95
|
0.80
|
0.80
|
|
HR
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
0.94
|
|
IP
|
459 ± 17
|
457 ± 17
|
461 ± 17
|
458 ± 15
|
473 ± 17
|
424 ± 52
|
|
C57
|
AR
|
0.90
|
0.95
|
0.85
|
0.90
|
0.95
|
0.75
|
|
HR
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
0.88
|
|
IP
|
464 ± 34
|
481 ± 22
|
448 ± 48
|
485 ± 24
|
491 ± 36
|
595 ± 77
|
|
VM
|
AR
|
0.90
|
1.00
|
1.00
|
0.95
|
1.00
|
1.00
|
|
HR
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
|
IP
|
579 ± 86
|
635 ± 85
|
635 ± 62
|
666 ± 61
|
629 ± 100
|
638 ± 64
|
- AR (Attack Rate) is the ratio of confirmed TSE positive mice over the number of inoculated mice (n = 20).
- HR (Hit Rate) is the ratio of TSE positive mice over the number of animals encountered after the first positive clinical animal.
- IP (Incubation Period) was recorded as days post inoculation and values indicate mean ± standard deviation. Only clinically and TSE confirmed positive mice were included in the IP assessment.
