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Table 1 Attack rate (AR), hit rate (HR) and incubation period (IP) of scrapie/BSE mixtures inoculated in three wild type mouse lines

From: Ability of wild type mouse bioassay to detect bovine spongiform encephalopathy (BSE) in the presence of excess scrapie

Mouse line Bioassay parameters Inoculum
100% scrapie 1% BSE 2% BSE 10% BSE 50% BSE 100% BSE
RIII AR 0.95 0.95 0.80 0.95 0.80 0.80
HR 1.00 1.00 1.00 1.00 1.00 0.94
IP 459 ± 17 457 ± 17 461 ± 17 458 ± 15 473 ± 17 424 ± 52
C57 AR 0.90 0.95 0.85 0.90 0.95 0.75
HR 1.00 1.00 1.00 1.00 1.00 0.88
IP 464 ± 34 481 ± 22 448 ± 48 485 ± 24 491 ± 36 595 ± 77
VM AR 0.90 1.00 1.00 0.95 1.00 1.00
HR 1.00 1.00 1.00 1.00 1.00 1.00
IP 579 ± 86 635 ± 85 635 ± 62 666 ± 61 629 ± 100 638 ± 64
  1. AR (Attack Rate) is the ratio of confirmed TSE positive mice over the number of inoculated mice (n = 20).
  2. HR (Hit Rate) is the ratio of TSE positive mice over the number of animals encountered after the first positive clinical animal.
  3. IP (Incubation Period) was recorded as days post inoculation and values indicate mean ± standard deviation. Only clinically and TSE confirmed positive mice were included in the IP assessment.
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