Figure 6From: Ability of wild type mouse bioassay to detect bovine spongiform encephalopathy (BSE) in the presence of excess scrapie Detection of PrP Sc types using immunohistochemistry in mouse brains. Mice challenged with BSE show BSE-characteristic punctuate PrPSc deposits (a, b) which are the only evident BSE feature in mice challenged with BSE/scrapie mixtures (c, d) in a pattern that is otherwise indistinguishable from scrapie (e, f). The content of BSE in the BSE/scrapie mixture used to inoculate the mice shown in c and d was 50%; a, c, e superior coliculus; b, d, f thalamus. Scale bar represents 50 μm. PrPSc was detected with a polyclonal rabbit antibody Rb486 diluted 1/2000.Back to article page