Figure 2

Regional, disease-specific reduction in KLK6 level in DLB, and inverse correlation with α-syn load in human post-mortem brain tissue. KLK6 level was reduced significantly in the a cingulate cortex and d thalamus in DLB but not in the b parahippocampal cortex or c frontal cortex. In the cingulate cortex only, KLK6 correlated inversely with e total α-syn and f α-syn-P129 level. In a-d the horizontal bars indicate the mean value and SEM. In e-f the solid lines indicate best fit linear regression and the interrupted lines the 95% confidence intervals. In all of the panels, each point represents a separate brain. *P < 0.05.