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Figure 1 | Acta Neuropathologica Communications

Figure 1

From: Stereological study of the neuronal number and volume of 38 brain subdivisions of subjects diagnosed with autism reveals significant alterations restricted to the striatum, amygdala and cerebellum

Figure 1

Delineation of the striatum subdivisions, the amygdala nuclei and anterior portion of the entorhinal cortex. Panel A shows three serial coronal sections (271, 313, and 334) stained with cresyl violet. Rectangles mark inserts that are shown enlarged in panel B. Section 271 shows delineation of the caudate nucleus (CN), putamen (Pu) and nucleus accumbens (Ac). Enlargements of sections 313 and 334 demonstrate the borders of the lateral (L), basal (B), accessory basal (AB), and central (C) nuclei within the amygdaloid complex. The adjacent median (M) nucleus, preamygdaloid cortex (PAC), and ventral claustrum (VCl) are marked. The borders of the enorhinal cortex (EC) are delinated including the borderline with the transentorhinal cortex (TEC) and PAC. Higher magnification (Panel C) shows EC layers typical for the mid-level of the rostrocaudal EC extension including layer I (molecular layer); islands of stellate neurons in layer II; a broad layer III; and acellular layer IV. On this level large darkly stained neurons form narrow layer (V), whereas the broad layer VI is built up of the smallest neurons, with decreasing gradient of neuronal density in the deeper part of this layer and a diffuse border with white matter (WM). Other examined structures: globus pallidus (GP), claustrum (Cl), and thalamus (Th). Calibration bar length: 10 mm, 5 mm, and 500 μm.

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