Edison P, Rowe CC, Rinne JO, Ng S, Ahmed I, Kemppainen N, Villemagne VL, O'Keefe G, Någren K, Chaudhury KR, Masters CL, Brooks DJ: Amyloid load in Parkinson's disease dementia and Lewy body dementia measured with [11C]PIB positron emission tomography. J Neurol Neurosurg Psychiatry 2008, 79(12):1331–1338. 10.1136/jnnp.2007.127878
Article
CAS
PubMed
Google Scholar
Resende R, Marques SC, Ferreiro E, Simões I, Oliveira CR, Pereira CM: Effect of α-synuclein on amyloid β-induced toxicity: relevance to Lewy body variant of Alzheimer disease. Neurochem Res 2013, 38(4):797–806. 10.1007/s11064-013-0982-7
Article
CAS
PubMed
Google Scholar
Hamilton RL: Lewy bodies in Alzheimer's disease: a neuropathological review of 145 cases using alpha-synuclein immunohistochemistry. Brain Pathol 2000, 10: 378–384. 10.1111/j.1750-3639.2000.tb00269.x
Article
CAS
PubMed
Google Scholar
Pronin AN, Morris AJ, Surguchov A, Benovic JL: Synucleins are a novel class of substrates for G protein-coupled receptor kinases. J Biol Chem 2000, 275(34):26515–26522. 10.1074/jbc.M003542200
Article
CAS
PubMed
Google Scholar
Foulds PG, Mitchell JD, Parker A, Turner R, Green G, Diggle P, Hasegawa M, Taylor M, Mann D, Allsop D: Phosphorylated α-synuclein can be detected in blood plasma and is potentially a useful biomarker for Parkinson's disease. FASEB J 2011, 25(12):4127–4137. 10.1096/fj.10-179192
Article
CAS
PubMed
Google Scholar
Foulds PG, Diggle P, Mitchell JD, Parker A, Hasegawa M, Masuda-Suzukake M, Mann DM, Allsop D: A longitudinal study on α-synuclein in blood plasma as a biomarker for Parkinson's disease. Sci Rep 2013, 3: 2540. 10.1038/srep02540
Article
PubMed
PubMed Central
Google Scholar
Galvin JE, Uryu K, Lee VM, Trojanowski JQ: Axon pathology in Parkinson's disease and Lewy body dementia hippocampus contains alpha-, beta-, and gamma-synuclein. Proc Natl Acad Sci U S A 1999, 96: 13450–13455. 10.1073/pnas.96.23.13450
Article
CAS
PubMed
PubMed Central
Google Scholar
Galvin JE, Giasson B, Hurtig HI, Lee VM, Trojanowski JQ: Neurodegeneration with brain iron accumulation, type 1 is characterized by alpha-, beta-, and gamma-synuclein neuropathology. Am J Pathol 2000, 157: 361–368. 10.1016/S0002-9440(10)64548-8
Article
CAS
PubMed
PubMed Central
Google Scholar
Ninkina N, Peters O, Millership S, Salem H, van der Putten H, Buchman VL: Gamma-synucleinopathy: neurodegeneration associated with overexpression of the mouse protein. Hum Mol Genet 2009, 18(10):1779–1794. 10.1093/hmg/ddp090
Article
CAS
PubMed
PubMed Central
Google Scholar
Surgucheva I, McMahan B, Ahmed F, Tomarev S, Wax MB, Surguchov A: Synucleins in glaucoma: implication of gamma-synuclein in glaucomatous alterations in the optic nerve. J Neurosci Res 2002, 68: 97–106. 10.1002/jnr.10198
Article
CAS
PubMed
Google Scholar
Nguyen JV, Soto I, Kim KY, Bushong EA, Oglesby E, Valiente-Soriano FJ, Yang Z, Davis CH, Bedont JL, Son JL, Wei JO, Buchman VL, Zack DJ, Vidal-Sanz M, Ellisman MH, Marsh-Armstrong N: Myelination transition zone astrocytes are constitutively phagocytic and have synuclein dependent reactivity in glaucoma. Proc Nat. Acad Sci U S A 2011, 108: 1176–1181. 10.1073/pnas.1013965108
Article
CAS
Google Scholar
Peters OM, Millership S, Shelkovnikova TA, Soto I, Keeling L, Hann A, Marsh-Armstrong N, Buchman VL, Ninkina N: Selective pattern of motor system damage in gamma-synuclein transgenic mice mirrors the respective pathology in amyotrophic lateral sclerosis. Neurobiol Dis 2012, 48: 124–131. 10.1016/j.nbd.2012.06.016
Article
CAS
PubMed
PubMed Central
Google Scholar
Nishioka K, Wider C, Vilariño-Güell C, Soto-Ortolaza AI, Lincoln SJ, Kachergus JM, Jasinska-Myga B, Ross OA, Rajput A, Robinson CA, Ferman TJ, Wszolek ZK, Dickson DW, Farrer MJ: Association of alpha-, beta-, and gamma-synuclein with diffuse Lewy body disease. Arch Neurol 2010, 67(8):970–975. 10.1001/archneurol.2010.177
Article
PubMed
PubMed Central
Google Scholar
Wersinger C, Sidhu A: Partial regulation of serotonin transporter function by gamma-synuclein. Neurosci Lett 2009, 453(3):157–161. 10.1016/j.neulet.2009.02.033
Article
CAS
PubMed
PubMed Central
Google Scholar
Surgucheva I, Sharov VS, Surguchov A: γ-Synuclein: seeding of α-synuclein aggregation and transmission between cells. Biochemistry 2012, 51(23):4743–4754. 10.1021/bi300478w
Article
CAS
PubMed
Google Scholar
Lema Tomé CM, Tyson T, Rey NL, Grathwohl S, Britschgi M, Brundin P: Inflammation and α-synuclein's prion-like behavior in Parkinson's disease–is there a link? Mol Neurobiol 2013, 47(2):561–574. 10.1007/s12035-012-8267-8
Article
PubMed
Google Scholar
Olanow CW, Brundin P: Parkinson's disease and alpha synuclein: is Parkinson's disease a prion-like disorder? Mov Disord 2013, 28(1):31–40. 10.1002/mds.25373
Article
CAS
PubMed
Google Scholar
Sacino AN, Brooks M, Thomas MA, McKinney AB, Lee S, Regenhardt RW, McGarvey NH, Ayers JI, Notterpek L, Borchelt DR, Golde TE, Giasson BI: Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice. Proc Natl Acad Sci U S A 2014, 111(29):10732–10737. 10.1073/pnas.1321785111
Article
CAS
PubMed
PubMed Central
Google Scholar
Fujiwara H, Hasegawa M, Dohmae N, Kawashima A, Masliah E, Goldberg MS, Shen J, Takio K, Iwatsubo T: alpha-Synuclein is phosphorylated in synucleinopathy lesions. Nat Cell Biol 2002, 4(2):160–164.
CAS
PubMed
Google Scholar
Oueslati A, Fournier M, Lashuel HA: Role of post-translational modifications in modulating the structure, function and toxicity of alpha-synuclein: implications for Parkinson's disease pathogenesis and therapies. Prog Brain Res 2010, 183: 115–145. 10.1016/S0079-6123(10)83007-9
Article
CAS
PubMed
Google Scholar
Braithwaite SP, Stock JB, Mouradian MM: α-Synuclein phosphorylation as a therapeutic target in Parkinson's disease. Rev Neurosci 2012, 23(2):191–198.
Article
CAS
PubMed
Google Scholar
Vicente Miranda H, Xiang W, de Oliveira RM, Simões T, Pimentel J, Klucken J, Penque D, Outeiro TF: Heat-mediated enrichment of α-synuclein from cells and tissue for assessing post-translational modifications. J Neurochem 2013, 126(5):673–684. 10.1111/jnc.12251
Article
PubMed
Google Scholar
Kokoulina P, Rohn TT: Caspase-cleaved transactivation response DNA-binding protein 43 in Parkinson's disease and dementia with Lewy bodies. Neurodegener Dis 2010, 7(4):243–250.
CAS
PubMed
PubMed Central
Google Scholar
Halliday GM, Stevens CH: Glia: initiators and progressors of pathology in Parkinson's disease. Mov Disord 2011, 26(1):6–17. 10.1002/mds.23455
Article
PubMed
Google Scholar
Sacino AN1, Thomas MA, Ceballos-Diaz C, Cruz PE, Rosario AM, Lewis J, Giasson BI, Golde TE: Conformational templating of α-synuclein aggregates in neuronal-glial cultures. Mol Neurodegener 2013, 8: 17. doi:10.1186/1750–1326–8-17 10.1186/1750-1326-8-17
Article
CAS
PubMed
PubMed Central
Google Scholar
Sosunov AA, Guilfoyle E, Wu X, McKhann GM 2nd, Goldman JE: Phenotypic conversions of "protoplasmic" to "reactive" astrocytes in Alexander disease. J Neurosci 2013, 33(17):7439–7450. 10.1523/JNEUROSCI.4506-12.2013
Article
CAS
PubMed
PubMed Central
Google Scholar
Sosunov AA, Wu X, Tsankova NM, Guilfoyle E, McKhann GM 2nd, Goldman JE: Phenotypic heterogeneity and plasticity of isocortical and hippocampal astrocytes in the human brain. J Neurosci 2014, 34(6):2285–2298. 10.1523/JNEUROSCI.4037-13.2014
Article
CAS
PubMed
PubMed Central
Google Scholar
Braak H, Sastre M, Del Tredici K: Development of alpha-synuclein immunoreac-tive astrocytes in the forebrain parallels stages of intraneuronal pathology in sporadic Parkinson's disease. Acta Neuropathol 2007, 114: 231–241. 10.1007/s00401-007-0244-3
Article
CAS
PubMed
Google Scholar
Kovacs GG, Breydo L, Green R, Kis V, Puska G, Lörincz P, Perju-Dumbrava L, Giera R, Pirker W, Lutz M, Lachmann I, Budka H, Uversky VN, Molnár K, László L: Intracellular processing of disease-associated α-synuclein in the human brain suggests prion-like cell-to-cell spread. Neurobiol Dis 2014, 69: 76–92. 10.1016/j.nbd.2014.05.020
Article
CAS
PubMed
Google Scholar
Tsigelny IF, Crews L, Desplats P, Shaked GM, Sharikov Y, Mizuno H, Spencer B, Rockenstein E, Trejo M, Platoshyn O, Yuan JX, Masliah E: Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases. PLoS One 2008, 3: e3135. doi:10.1371/journal.pone.0003135 10.1371/journal.pone.0003135
Article
PubMed
PubMed Central
Google Scholar
Forman MS, Schmidt ML, Kasturi S, Perl DP, Lee VM, Trojanowski JQ: Tau and alpha-synuclein pathology in amygdala of Parkinsonism-dementia complex patients of Guam. Am J Pathol 2002, 160(5):1725–1731. 10.1016/S0002-9440(10)61119-4
Article
CAS
PubMed
PubMed Central
Google Scholar
Badiola N, de Oliveira RM, Herrera F, Guardia-Laguarta C, Goncalves SA, Pera M, Suarez-Calvet M, Clarimon J, Outeiro TF, Lleó A: Tau enhances alpha-synuclein aggregation and toxicity in cellular models of synucleinopathy. PLoS One 2011, 6(10):e26609. 10.1371/journal.pone.0026609
Article
CAS
PubMed
PubMed Central
Google Scholar
Clinton LK, Blurton-Jones M, Myczek K, Trojanowski JQ, LaFerla FM: Synergistic interactions between Abeta, tau, and alpha-synuclein: acceleration of neuropathology and cognitive decline. J Neurosci 2010, 30(21):7281–7289. 10.1523/JNEUROSCI.0490-10.2010
Article
CAS
PubMed
PubMed Central
Google Scholar
Masliah E, Rockenstein E, Veinbergs I, Sagara Y, Mallory M, Hashimoto M, Mucke L: Beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease. Proc Natl Acad Sci U S A 2001, 98(21):12245–12250. 10.1073/pnas.211412398
Article
CAS
PubMed
PubMed Central
Google Scholar
Giasson BI, Forman MS, Higuchi M, Golbe LI, Graves CL, Kotzbauer PT, Trojanowski JQ, Lee VM: Initiation and synergistic fibrillization of tau and alpha-synuclein. Science 2003, 300: 636–640. 10.1126/science.1082324
Article
CAS
PubMed
Google Scholar
Mukaetova-Ladinska EB, Milne J, Andras A, Abdel-All Z, Cerejeira J, Greally E, Robson J, Jaros E, Perry R, McKeith IG, Brayne C, Xuereb J, Cleghorn A, Doherty J, McIntosh G, Milton I: Alpha- and gamma-synuclein proteins are present in cerebrospinal fluid and are increased in aged subjects with neurodegenerative and vascular changes. Dement Geriatr Cogn Disord 2008, 26(1):32–42. doi:10.1159/000141039 10.1159/000141039
Article
CAS
PubMed
Google Scholar
Surguchov A: Synucleins: are they two-edged swords? J Neurosci Res 2013, 91(2):161–166. 10.1002/jnr.23149
Article
CAS
PubMed
Google Scholar