Field excitatory post-synaptic potentials (fEPSP) recorded from the ventral hippocampus in R26CT and R26CT-CRE mice. A) Stimulus response curves for R26CT (black squares n = 10(19)) and R26CT-CRE (open circles, n = 12(18)) mice at 3 months of age. Input intensities are 30, 40, 50, 60, 75, 90, 110, 130, 150, and 170 μA. B) Averaged fEPSP sweeps for each group shown in A. The vertical bar represents 2 mV and the sweeps are 50 ms in duration. C, D) Same as A and B above except at 8 months of age for R26CT (n = 10(20)) and R26CT-CRE (n = 12(19)). The values represent the mean ± SEM from n slices. There are no significant differences between genotypes at either 3 or 8 months of age. Significance between genotypes was determined using an unpaired t-test.