Lee VM, Goedert M, Trojanowski JQ: Neurodegenerative tauopathies. Annu Rev Neurosci 2001, 24: 1121–1159. 10.1146/annurev.neuro.24.1.1121
CAS
PubMed
Google Scholar
Morris M, Maeda S, Vossel K, Mucke L: The many faces of tau. Neuron 2011,70(3):410–426. 10.1016/j.neuron.2011.04.009
PubMed Central
CAS
PubMed
Google Scholar
Braak H, Thal DR, Ghebremedhin E, Del Tredici K: Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years. J Neuropathol Exp Neurol 2011,70(11):960–969. 10.1097/NEN.0b013e318232a379
CAS
PubMed
Google Scholar
Selkoe DJ: Alzheimer’s disease is a synaptic failure. Science 2002,298(5594):789–791. 10.1126/science.1074069
CAS
PubMed
Google Scholar
Hoover BR, Reed MN, Su J, et al.: Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration. Neuron 2010,68(6):1067–1081. 10.1016/j.neuron.2010.11.030
PubMed Central
CAS
PubMed
Google Scholar
Ittner LM, Ke YD, Delerue F, Bi M, Gladbach A, van Eersel J, Wölfing H, Chieng BC, Christie MJ, Napier IA: Dendritic function of tau mediates amyloid-β toxicity in Alzheimer’s disease mouse models. Cell 2010, 142: 387–397. 10.1016/j.cell.2010.06.036
CAS
PubMed
Google Scholar
Roberson ED, Scearce-Levie K, Palop JJ, Yan F, Cheng IH, Wu T, Gerstein H, Yu G-Q, Mucke L: Reducing endogenous tau ameliorates amyloid β-induced deficits in an Alzheimer’s disease mouse model. Science 2007, 316: 750–754. 10.1126/science.1141736
CAS
PubMed
Google Scholar
Kopeikina KJ, Polydoro M, Tai H-C, Yaeger E, Carlson GA, Pitstick R, Hyman BT, Spires-Jones TL: Synaptic alterations in the rTg4510 mouse model of tauopathy. J Comp Neurol 2013,521(6):1334–1353. 10.1002/cne.23234
PubMed Central
CAS
PubMed
Google Scholar
Rocher AB, Crimins JL, Amatrudo JM, Kinson MS, Todd-Brown MA, Lewis J, Luebke JI: Structural and functional changes in tau mutant mice neurons are not linked to the presence of NFTs. Exp Neurol 2010,223(2):385–393. 10.1016/j.expneurol.2009.07.029
PubMed Central
CAS
PubMed
Google Scholar
Yoshiyama Y, Higuchi M, Zhang B, Huang S-M, Iwata N, Saido TC, Maeda J, Suhara T, Trojanowski JQ, Lee VM-Y: Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron 2007,53(3):337–351. 10.1016/j.neuron.2007.01.010
CAS
PubMed
Google Scholar
Mocanu M-M, Nissen A, Eckermann K, et al.: The potential for β-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous tau in inducible mouse models of tauopathy. J Neurosci 2008,28(3):737–748. 10.1523/JNEUROSCI.2824-07.2008
CAS
PubMed
Google Scholar
Kremer A, Maurin H, Demedts D, Devijver H, Borghgraef P, Van Leuven F: Early improved and late defective cognition is reflected by dendritic spines in tau.P301L mice. J Neurosci 2011,31(49):18036–18047. 10.1523/JNEUROSCI.4859-11.2011
CAS
PubMed
Google Scholar
Dickstein DL, Brautigam H, Stockton SD, Schmeidler J, Hof PR: Changes in dendritic complexity and spine morphology in transgenic mice expressing human wild-type tau. Brain Struct Funct 2010,214(2–3):161–179.
PubMed Central
PubMed
Google Scholar
Allen B, Ingram E, Takao M, et al.: Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein. J Neurosci 2002,22(21):9340–9351.
CAS
PubMed
Google Scholar
Spires-Jones TL, Stoothoff WH, de Calignon A, Jones PB, Hyman BT: Tau pathophysiology in neurodegeneration: a tangled issue. Trends Neurosci 2009,32(3):150–159. 10.1016/j.tins.2008.11.007
CAS
PubMed
Google Scholar
Sperfeld A, Collatz M, Baier H, et al.: FTDP-17: an early onset phenotype with parkinsonism and epileptic seizures caused by a novel mutation. Ann Neurol 1999,46(5):708–715. 10.1002/1531-8249(199911)46:5<708::AID-ANA5>3.0.CO;2-K
CAS
PubMed
Google Scholar
Bellucci A, Westwood AJ, Ingram E, Casamenti F, Goedert M, Spillantini MG: Induction of inflammatory mediators and microglial activation in mice transgenic for mutant human P301S tau protein. Am J Pathol 2004,165(5):1643–1652. 10.1016/S0002-9440(10)63421-9
PubMed Central
CAS
PubMed
Google Scholar
Delobel P, Lavenir I, Fraser G, Ingram E, Holzer M, Ghetti B, Spillantini MG, Crowther RA, Goedert M: Analysis of tau phosphorylation and truncation in a mouse model of human tauopathy. Am J Pathol 2008,172(1):123–131. 10.2353/ajpath.2008.070627
PubMed Central
CAS
PubMed
Google Scholar
Gasparini L, Crowther RA, Martin KR, Berg N, Coleman M, Goedert M, Spillantini MG: Tau inclusions in retinal ganglion cells of human P301S tau transgenic mice: effects on axonal viability. Neurobiol Aging 2011,32(3):419–433. 10.1016/j.neurobiolaging.2009.03.002
CAS
PubMed
Google Scholar
Trachtenberg JT, Chen BE, Knott GW, Feng G, Sanes JR, Welker E, Svoboda K: Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex. Nature 2002,420(6917):788–794. 10.1038/nature01273
CAS
PubMed
Google Scholar
Hampton DW, Webber DJ, Bilican B, Goedert M, Spillantini MG, Chandran S: Cell-mediated neuroprotection in a mouse model of human tauopathy. J Neurosci 2010,30(30):9973–9983. 10.1523/JNEUROSCI.0834-10.2010
CAS
PubMed
Google Scholar
Scattoni ML, Gasparini L, Alleva E, Goedert M, Calamandrei G, Spillantini MG: Early behavioural markers of disease in P301S tau transgenic mice. Behav Brain Res 2010,208(1):250–257. 10.1016/j.bbr.2009.12.002
CAS
PubMed
Google Scholar
Blazquez-Llorca L, Garcia-Marin V, Merino-Serrais P, Ávila J, DeFelipe J: Abnormal tau phosphorylation in the thorny excrescences of CA3 hippocampal neurons in patients with Alzheimer’s disease. J Alzheimers Dis 2011,26(4):683–698.
CAS
PubMed
Google Scholar
Merino-Serrais P, Benavides-Piccione R, Blazquez-Llorca L, Kastanauskaite A, Rábano A, Avila J, DeFelipe J: The influence of phospho-tau on dendritic spines of cortical pyramidal neurons in patients with Alzheimer’s disease. Brain 2013, 136: 1913–1928. 10.1093/brain/awt088
PubMed Central
PubMed
Google Scholar
Feng G, Mellor RH, Bernstein M, Keller-Peck C, Nguyen QT, Wallace M, Nerbonne JM, Lichtman JW, Sanes JR: Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP. Neuron 2000,28(1):41–51. 10.1016/S0896-6273(00)00084-2
CAS
PubMed
Google Scholar
Fuhrmann M, Bittner T, Jung CKE, Burgold S, Page RM, Mitteregger G, Haass C, LaFerla FM, Kretzschmar H, Herms J: Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer’s disease. Nat Neurosci 2010,13(4):411–413. 10.1038/nn.2511
PubMed Central
CAS
PubMed
Google Scholar
Holtmaat A, Bonhoeffer T, Chow DK, et al.: Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window. Nat Protoc 2009,4(8):1128–1144. 10.1038/nprot.2009.89
PubMed Central
CAS
PubMed
Google Scholar
Harris KM, Jensen FE, Tsao B: Three-dimensional structure of dendritic spines and synapses in rat hippocampus (CA1) at postnatal day 15 and adult ages: implications for the maturation of synaptic physiology and long-term potentiation. J Neurosci 1992,12(7):2685–2705.
CAS
PubMed
Google Scholar
Higuchi M, Iwata N, Matsuba Y, Sato K, Sasamoto K, Saido TC: 19 F and 1H MRI detection of amyloid β plaques in vivo. Nat Neurosci 2005,8(4):527–533. 10.1038/nn1422
CAS
PubMed
Google Scholar
Sato K, Higuchi M, Iwata N, Saido TC, Sasamoto K: Fluoro-substituted and 13C-labeled styrylbenzene derivatives for detecting brain amyloid plaques. Eur J Med Chem 2004,39(7):573–578. 10.1016/j.ejmech.2004.02.013
CAS
PubMed
Google Scholar
Schön C, Hoffmann NA, Ochs SM, et al.: Long-term in vivo imaging of fibrillar tau in the retina of P301S transgenic mice. Plos One 2012,7(12):e53547. 10.1371/journal.pone.0053547
PubMed Central
PubMed
Google Scholar
Velasco A, Fraser G, Delobel P, Ghetti B, Lavenir I, Goedert M: Detection of filamentous tau inclusions by the fluorescent congo red derivative FSB [(trans, trans)-1-fluoro-2,5-bis(3-hydroxycarbonyl-4-hydroxy)styrylbenzene]. FEBS Lett 2008,582(6):901–906. 10.1016/j.febslet.2008.02.025
PubMed Central
CAS
PubMed
Google Scholar
De Calignon A, Spires-Jones TL, Pitstick R, Carlson GA, Hyman BT: Tangle-bearing neurons survive despite disruption of membrane integrity in a mouse model of tauopathy. J Neuropathol Exp Neurol 2009,68(7):757–761. 10.1097/NEN.0b013e3181a9fc66
PubMed Central
CAS
PubMed
Google Scholar
Brandt R, Hundelt M, Shahani N: Tau alteration and neuronal degeneration in tauopathies: mechanisms and models. Biochim Biophys Acta 2005,1739(2–3):331–354.
CAS
PubMed
Google Scholar
Götz J, Ittner LM: Animal models of Alzheimer’s disease and frontotemporal dementia. Nat Rev Neurosci 2008,9(7):532–544. 10.1038/nrn2420
PubMed
Google Scholar
Fu M, Zuo Y: Experience-dependent structural plasticity in the cortex. Trends Neurosci 2011,34(4):177–187. 10.1016/j.tins.2011.02.001
PubMed Central
CAS
PubMed
Google Scholar
Testa I, Urban NT, Jakobs S, Eggeling C, Willig KI, Hell SW: Nanoscopy of living brain slices with low light levels. Neuron 2012,75(6):992–1000. 10.1016/j.neuron.2012.07.028
CAS
PubMed
Google Scholar
Holtmaat A, Svoboda K: Experience-dependent structural synaptic plasticity in the mammalian brain. Nat Rev Neurosci 2009,10(9):647–658. 10.1038/nrn2699
CAS
PubMed
Google Scholar
Arellano JI, Espinosa A, Fairén A, Yuste R, DeFelipe J: Non-synaptic dendritic spines in neocortex. Neuroscience 2007,145(2):464–469. 10.1016/j.neuroscience.2006.12.015
CAS
PubMed
Google Scholar
Holtmaat AJGD, Trachtenberg JT, Wilbrecht L, Shepherd GM, Zhang X, Knott GW, Svoboda K: Transient and persistent dendritic spines in the neocortex in vivo. Neuron 2005,45(2):279–291. 10.1016/j.neuron.2005.01.003
CAS
PubMed
Google Scholar
Harris JA, Koyama A, Maeda S, Ho K, Devidze N, Dubal DB, Yu G-Q, Masliah E, Mucke L: Human P301L-mutant tau expression in mouse entorhinal-hippocampal network causes tau aggregation and presynaptic pathology but no cognitive deficits. PLOS ONE 2012,7(9):e45881. 10.1371/journal.pone.0045881
PubMed Central
CAS
PubMed
Google Scholar
Takahashi RH, Capetillo-Zarate E, Lin MT, Milner TA, Gouras GK: Co-occurrence of Alzheimer’s disease β-amyloid and tau pathologies at synapses. Neurobiol Aging 2010,31(7):1145–1152. 10.1016/j.neurobiolaging.2008.07.021
PubMed Central
CAS
PubMed
Google Scholar
Chicurel M, Harris K: Three-dimensional analysis of the structure and composition of CA3 branched dendritic spines and their synaptic relationships with mossy fiber boutons in the rat hippocampus. J Comp Neurol 1992,325(2):169–182. 10.1002/cne.903250204
CAS
PubMed
Google Scholar
Sorra K, Harris K: Overview on the structure, composition, function, development, and plasticity of hippocampal dendritic spines. Hippocampus 2000,10(5):501–511. 10.1002/1098-1063(2000)10:5<501::AID-HIPO1>3.0.CO;2-T
CAS
PubMed
Google Scholar
Higuchi M, Lee VMY, Trojanowski JQ: Tau and axonopathy in neurodegenerative disorders. Neuromolecular Med 2002,2(2):131–150. 10.1385/NMM:2:2:131
CAS
PubMed
Google Scholar
Leroy K, Bretteville A, Schindowski K, Gilissen E, Authelet M, De Decker R, Yilmaz Z, Buée L, Brion J-P: Early axonopathy preceding neurofibrillary tangles in mutant tau transgenic mice. Am J Pathol 2007,171(3):976–992. 10.2353/ajpath.2007.070345
PubMed Central
CAS
PubMed
Google Scholar
Spittaels K, Van den Haute C, Van Dorpe J, et al.: Prominent axonopathy in the brain and spinal cord of transgenic mice overexpressing four-repeat human tau protein. Am J Pathol 1999,155(6):2153–2165. 10.1016/S0002-9440(10)65533-2
PubMed Central
CAS
PubMed
Google Scholar
Druga R: Neocortical inhibitory system. Folia Biol 2009, 217: 201–217.
Google Scholar
Kettenmann H, Kirchhoff F, Verkhratsky A: Microglia: new roles for the synaptic stripper. Neuron 2013,77(1):10–18. 10.1016/j.neuron.2012.12.023
CAS
PubMed
Google Scholar
Wake H, Moorhouse A, Jinno S, Kohsaka S, Nabekura J: Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals. J Neurosci 2009,29(13):3974–3980. 10.1523/JNEUROSCI.4363-08.2009
CAS
PubMed
Google Scholar
Wake H, Moorhouse AJ, Miyamoto A, Nabekura J: Microglia: actively surveying and shaping neuronal circuit structure and function. Trends Neurosci 2013,36(4):209–217. 10.1016/j.tins.2012.11.007
CAS
PubMed
Google Scholar
SantaCruz K, Lewis J, Spires T, et al.: Tau suppression in a neurodegenerative mouse model improves memory function. Science 2005,309(5733):476–481. 10.1126/science.1113694
PubMed Central
CAS
PubMed
Google Scholar
Shahani N, Subramaniam S, Wolf T, Tackenberg C, Brandt R: Tau aggregation and progressive neuronal degeneration in the absence of changes in spine density and morphology after targeted expression of Alzheimer’s disease-relevant tau constructs in organotypic hippocampal slices. J Neurosci 2006,26(22):6103–6114. 10.1523/JNEUROSCI.4245-05.2006
CAS
PubMed
Google Scholar
Lasagna-Reeves CA, Castillo-Carranza DL, Sengupta U, Guerrero-Munoz MJ, Kiritoshi T, Neugebauer V, Jackson GR, Kayed R: Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau. Sci Rep 2012, 2: 700.
PubMed Central
PubMed
Google Scholar
Patterson KR, Remmers C, Fu Y, et al.: Characterization of prefibrillar tau oligomers in vitro and in Alzheimer disease. J Biol Chem 2011,286(26):23063–23076. 10.1074/jbc.M111.237974
PubMed Central
CAS
PubMed
Google Scholar
Ward SM, Himmelstein DS, Lancia JK, Binder LI: Tau oligomers and tau toxicity in neurodegenerative disease. Biochem Soc Trans 2012,40(4):667–671. 10.1042/BST20120134
PubMed Central
CAS
PubMed
Google Scholar