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Table 2 Pharmacological targeting of molecular chaperones in neurotoxin-induced models of Parkinson’s disease

From: Molecular chaperones and protein folding as therapeutic targets in Parkinson’s disease and other synucleinopathies

Compound Disease model Readout Reference
Geldanamycin MPTP mouse model • Chaperone and HSF-1 levels Shen et al. 2005 [181]
• Dopamine levels
• Toxicity
Celastrol MPTP mouse model • Hsp70 levels Cleren et al. 2005 [184]
• Dopamine levels
• Toxicity
Trehalose Epoxomicin cell model • α-synuclein aggregation Casarejos et al. 2011 [185]
• α-synuclein and chaperone levels
• Macroautophagy markers
• Proteasome activity
• Oxidative stress
• Toxicity
4-phenylbutyrate Rotenone mouse model • α-synuclein aggregation Inden et al. 2007 [186]
• α-synuclein levels
• Dopamine levels
• Behavioral deficits
• Oxidative stress
• Toxicity