Compound | Disease model | Readout | Reference |
---|---|---|---|
Geldanamycin | MPTP mouse model | • Chaperone and HSF-1 levels | Shen et al. 2005 [181] |
• Dopamine levels | |||
• Toxicity | |||
Celastrol | MPTP mouse model | • Hsp70 levels | Cleren et al. 2005 [184] |
• Dopamine levels | |||
• Toxicity | |||
Trehalose | Epoxomicin cell model | • α-synuclein aggregation | Casarejos et al. 2011 [185] |
• α-synuclein and chaperone levels | |||
• Macroautophagy markers | |||
• Proteasome activity | |||
• Oxidative stress | |||
• Toxicity | |||
4-phenylbutyrate | Rotenone mouse model | • α-synuclein aggregation | Inden et al. 2007 [186] |
• α-synuclein levels | |||
• Dopamine levels | |||
• Behavioral deficits | |||
• Oxidative stress | |||
• Toxicity |