Table 2 Pharmacological targeting of molecular chaperones in neurotoxin-induced models of Parkinson’s disease

Geldanamycin

MPTP mouse model

• Chaperone and HSF-1 levels

Shen et al. 2005 [181]

• Dopamine levels

• Toxicity

Celastrol

MPTP mouse model

• Hsp70 levels

Cleren et al. 2005 [184]

• Dopamine levels

• Toxicity

Trehalose

Epoxomicin cell model

• α-synuclein aggregation

Casarejos et al. 2011 [185]

• α-synuclein and chaperone levels

• Macroautophagy markers

• Proteasome activity

• Oxidative stress

• Toxicity

4-phenylbutyrate

Rotenone mouse model

• α-synuclein aggregation

Inden et al. 2007 [186]

• α-synuclein levels

• Dopamine levels

• Behavioral deficits

• Oxidative stress

• Toxicity