Figure 3
Ultrastructural localisation of PrP using antibody 12F10 in the same frontal cortex section where light microscopical immunohistochemistry revealed linear and worm-like immunoreactivity. Panel a-d demonstrates immunogold labeling specific for PrP mainly associated with endosome-like structures in the pericaryon (indicated by arrows; Nu: nucleus). Intraneuritic accumulation of PrP in longitudinal (e) and cross (f) sections of myelinated axons. Measuring bars represent 2 μm in a, c, d, and e, and 500 nm in b and f.