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Figure 2 | Acta Neuropathologica Communications

Figure 2

From: The link between intraneuronal N-truncated amyloid-β peptide and oxidatively modified lipids in idiopathic autism and dup(15q11.2-q13)/autism

Figure 2

MDA immunoreactivity in large pyramidal neurons in layers 3 or 5 of frontal cortex in 10-year-old individual with dup(15)/autism [dup(15)] and in 8-year-old control subject (contr) brains. Mitochondria, visualized by immunostaining for cytochrome c oxidase COX IV, were the site of weak reactivity for MDA in control but a strong reactivity in dup(15)/autism brain. Most autophagic vacuoles (detected with antibody LC3B) and lysosomes/late endosomes (detected by the presence of Lamp-1 glycoprotein) did not contain a significant fraction of MDA. Bars 10 μm.

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Acta Neuropathologica Communications

ISSN: 2051-5960

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