Fig. 7
From: LINC complex alterations are a key feature of sporadic and familial ALS/FTD
LINC complex disruption correlates with nuclear morphological alterations in ALS MNs. a. Representative images of spinal motor neurons from control (top), sALS (middle), and C9-ALS (bottom) with normal or abnormal SUN1 or SUN2 staining. The dashed yellow lines indicate the cells contour, white dots identify the nucleus, and yellow dots highlight the nucleolus. b-e. The quantification of the relative nuclear (b, d) and nucleolar (c, e) area in cells categorized based on the presence of a normal or abnormal SUN1 (b, c) or SUN2 (c, e) nuclear staining shows a significant correlation between LINC complex disruption and smaller nuclear and sub-nuclear structures (one-way ANOVA with Tukey post hoc test, n = 22, 47, and 15 in b and c, n = 15, 26, and 10 in d and e, *p < 0.05, **p < 0.01, ****p < 0.0001, ns = not significant)