Table 1 Study cohort data and neuropathological scoring. Cases were selected by pathology and grouped into four cohorts: Control; MIX; AD; LBD. Neuropathological scores were evaluated by a board-certified neuropathologist
Case # | Study group | Pathological diagnosis | Thal | Braak | Cerad | LB Score (McKeith) | APOE | Gender | Age | PMI | Exp |
|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Control | PART, definite, Braak II | 0 | II | None | None | 3/3 | m | 85 | NA | 1 |
2 | Control | Atherosclerosis (moderate) | 0 | 0 | None | None | 3/3 | m | 71 | NA | 1 |
3 | Control | Atherosclerosis (moderate) | 0 | 0 | None | None | 3/3 | m | 88 | 5 | 1 |
4 | Control | PART, definite, Braak I | 0 | I | None | None | 3/3 | m | 87 | NA | 1 |
5 | Control | PART, definite, Braak I | 0 | I | None | None | 3/3 | m | 77 | NA | 1 |
6 | Control | Acute microinfarcts | 0 | 0 | None | None | 3/3 | m | 72 | 4 | 1 |
7 | Control | PART, definite, Braak I | 0 | I | None | None | 2/3 | f | 73 | NA | 1 |
8 | Control | PART, definite, Braak II | 0 | II | None | None | N/A | f | 82 | NA | 1 |
9 | Control | PART, definite, Braak II | 0 | II | None | None | 3/3 | f | 90 | NA | 1 |
10 | Control | PART, definite, Braak I | 0 | I | None | None | 3/3 | f | 78 | 5 | 1 |
11 | Control | PART, definite, Braak I | 0 | I | None | None | 2/3 | m | 74 | 5 | 1 |
12 | Control | PART, definite, Braak II | 0 | II | None | None | 3/3 | m | 77 | 6 | 1 |
13 | Control | PART, definite, Braak I | 0 | I | None | None | 2/3 | m | 51 | NA | 1 |
14 | Control | PART, definite, Braak I | 0 | I | None | None | 2/3 | m | 52 | NA | 1 |
15 | Control | Atherosclerosis (moderate) | 1 | I | None | None | 3/3 | m | 84 | NA | 1,2 |
16 | Control | PART, Braak I | 0 | I | None | None | 3/3 | f | 76 | 10 | 1,2 |
17 | Control | PART, Braak I | 0 | I | None | None | 3/3 | m | 71 | 6 | 1,2,3 |
18 | Control | AD low | 1 | II | None | None | 3/3 | m | 90 | 14 | 1,2 |
19 | Control | AD low | 1 | II | None | None | 3/3 | m | 88 | 4 | 1,2 |
20 | Control | PART, definite, Braak II | 0 | II | None | None | 3/3 | f | 72 | 4 | 1,2,3 |
21 | Control | CVD | 1 | II | None | None | 3/3 | f | 90 | 56 | 1,3 |
22 | Control | PART, definite, Braak II | 0 | II | None | None | 3/3 | m | 77 | 12 | 1,2 |
23 | Control | Control | 0 | 0 | None | None | 3/4 | f | 55 | 12 | 1,2,3 |
24 | MIX | AD high | 5 | VI | Frequent | Diffuse neocortical | 4/4 | f | 78 | 13 | 1 |
25 | MIX | AD high | 5 | VI | Frequent | Diffuse neocortical | 3/4 | m | 78 | 22 | 1 |
26 | MIX | AD high | 5 | VI | Frequent | Diffuse neocortical | 4/4 | m | 90+ | 14.25 | 1 |
27 | MIX | AD high | 4 | V | Frequent | Diffuse neocortical | 3/4 | f | 76 | 20 | 1,3 |
28 | MIX | AD high | 5 | VI | Frequent | Diffuse neocortical | 3/3 | m | 83 | 69 | 1 |
29 | MIX | AD high | 5 | VI | Frequent | Diffuse neocortical | 3/3 | m | 62 | 5 | 1,3 |
30 | MIX | AD high | 5 | VI | Frequent | Limbic-transitional | 4/4 | f | 76 | 3 | 1 |
31 | MIX | AD high | 5 | VI | Frequent | Limbic-transitional | 3/3 | f | 81 | 7 | 1 |
32 | MIX | AD high | 5 | VI | Frequent | Limbic-Transitional | 3/4 | m | 64 | 6 | 1 |
33 | MIX | AD high | 5 | V | Frequent | Limbic-transitional | 3/3 | f | 78 | 12 | 1 |
34 | MIX | AD high | 5 | V | Frequent | Diffuse neocortical | 3/3 | f | 63 | 12 | 1 |
35 | MIX | AD high | 5 | V | Frequent | Diffuse neocortical | 2/3 | f | 90+ | 9 | 1 |
36 | MIX | AD high | 5 | V | Frequent | Diffuse neocortical | 4/4 | f | 90+ | 18 | 1 |
37 | MIX | AD high | 5 | VI | Frequent | Diffuse neocortical | 4/4 | f | 75 | NA | 1,3 |
38 | MIX | AD high | 5 | V | Frequent | Limbic-Transitional | 4/4 | f | 85 | NA | 1 |
39 | MIX | AD high | 5 | V | Frequent | Diffuse neocortical | 3/4 | m | 74 | 7 | 1 |
40 | MIX | AD high | 5 | VI | Frequent | Diffuse neocortical | 3/3 | m | 87 | 9 | 1,2,3 |
41 | MIX | AD high | 4 | V | Frequent | Diffuse neocortical | 3/4 | m | 77 | 17 | 1,2,3 |
42 | MIX | AD high | 5 | V | Frequent | Diffuse neocortical | 3/4 | f | 83 | 6 | 1,2,3 |
43 | MIX | AD high | 5 | V | Frequent | Diffuse neocortical | 3/4 | m | 80 | 21 | 1,2,3 |
44 | MIX | AD high | 5 | V | Frequent | Diffuse neocortical | 2/4 | f | 74 | 8 | 1,2 |
45 | MIX | AD high | 5 | V | Frequent | Diffuse neocortical | 3/4 | f | 68 | 6 | 1,2,3 |
46 | AD | AD high | 5 | VI | Frequent | None | 3/4 | m | 81 | 4 | 1 |
47 | AD | AD high | 5 | VI | Frequent | None | 3/4 | m | 63 | 2 | 1 |
48 | AD | AD high | 5 | VI | Frequent | None | 3/3 | m | 66 | 5 | 1,3 |
49 | AD | AD high | 4 | V | Frequent | None | 3/4 | m | 77 | 5 | 1 |
50 | AD | AD high | 5 | V | Frequent | None | 2/4 | f | 90+ | 10 | 1 |
51 | AD | AD high | 5 | V | Frequent | None | 3/3 | m | 90+ | 5 | 1 |
52 | AD | AD high | 5 | VI | Frequent | None | 3/3 | m | 83 | 7 | 1 |
53 | AD | AD high | 5 | VI | Frequent | None | 3/4 | m | 59 | 7 | 1,3 |
54 | AD | AD high | 5 | V | Frequent | None | 3/3 | f | 64 | 12 | 1 |
55 | AD | AD high | 5 | VI | Frequent | None | 4/4 | m | 74 | 36 | 1 |
56 | AD | AD high | 5 | V | Frequent | None | 3/4 | f | 86 | 14 | 1 |
57 | AD | AD high | 5 | VI | Frequent | None | 3/3 | m | 60 | 20 | 1 |
58 | AD | AD high | 5 | VI | Frequent | None | 4/4 | m | 70 | 8 | 1,3 |
59 | AD | AD high | 5 | V | Frequent | None | 2/3 | m | 74 | 2 | 1 |
60 | AD | AD high | 4 | VI | Frequent | None | 4/4 | m | 75 | NA | 1 |
61 | AD | AD high | 5 | VI | Frequent | None | N/A | f | 75 | NA | 1 |
62 | AD | AD high | 5 | VI | Frequent | None | 3/3 | f | 86 | 6 | 1 |
63 | AD | AD high | 5 | VI | Frequent | None | 3/3 | f | 84 | NA | 1,3 |
64 | AD | AD high | 5 | V | Frequent | None | N/A | f | 82 | NA | 1 |
65 | AD | AD high | 5 | V | Frequent | None | 3/3 | f | 90 | NA | 1 |
66 | AD | AD high | 5 | V | Frequent | None | 3/3 | m | 87 | NA | 1 |
67 | AD | AD high | 5 | V | Frequent | None | 3/3 | m | 73 | NA | 1 |
68 | AD | AD high | 4 | V | Frequent | None | 3/4 | m | 84 | 16 | 1,2 |
69 | AD | AD high | 4 | V | Frequent | None | 3/4 | f | 85 | 18 | 1 |
70 | AD | AD high | 5 | V | Frequent | None | 3/4 | f | 72 | 12 | 1,2 |
71 | AD | AD high | 5 | V | Frequent | None | 3/3 | f | 78 | 5 | 1,2 |
72 | AD | AD high | 4 | V | Frequent | None | 3/3 | f | 78 | 20 | 1 |
73 | AD | AD high | 5 | V | Frequent | None | 3/4 | m | 78 | 20 | 1,2 |
74 | AD | AD high | 5 | VI | Frequent | None | 3/3 | m | 83 | 18 | 1,2 |
75 | LBD | LBD | 3 | II | None | Limbic-transitional | 3/3 | m | 83 | 18 | 1 |
76 | LBD | LBD | 3 | II | Sparse | Diffuse neocortical | 3/4 | m | 68 | 8 | 1,3 |
77 | LBD | LBD | 3 | I | None | Diffuse neocortical | 2/3 | m | 69 | 3 | 1 |
78 | LBD | LBD | 2 | I | None | Brainstem predominant | 3/3 | m | 77 | NA | 1 |
79 | LBD | LBD | 0 | I | None | Diffuse neocortical | 2/3 | m | 80 | 3 | 1,3 |
80 | LBD | LBD | 2 | II | None | Limbic-transitional | 3/3 | f | 86 | 11 | 1,3 |
81 | LBD | LBD | 3 | I | None | Brainstem predominant | 3/3 | m | 57 | 17 | 1,3 |
82 | LBD | LBD | 2 | I | None | Brainstem predominant | 3/3 | m | 84 | 13 | 1,3 |
83 | LBD | LBD | 3 | II | None | Diffuse neocortical | 3/3 | f | 67 | 8 | 1 |
84 | LBD | LBD | 3 | II | Sparse | Brainstem predominant | 2/3 | m | 90+ | 9 | 1,3 |
85 | LBD | LBD | 1 | II | None | Limbic-transitional | 3/4 | m | 75 | 12 | 1 |
86 | LBD | LBD | 3 | II | None | Diffuse neocortical | 3/4 | m | 80 | 7 | 1 |
87 | LBD | LBD | 3 | II | None | Diffuse neocortical | 3/3 | m | 83 | NA | 1 |
88 | LBD | LBD | 3 | II | None | Diffuse neocortical | 3/3 | m | 76 | 11 | 1,2 |
89 | LBD | LBD | 3 | II | Moderate | Diffuse neocortical | 3/3 | m | 80 | 4 | 1,2,3 |
90 | LBD | LBD | 3 | II | Sparse | Diffuse neocortical | 3/3 | m | 79 | < 15 | 1,2,3 |
91 | LBD | LBD | 0 | II | None | Diffuse neocortical | 3/3 | m | 85 | 12 | 1,2,3 |
92 | LBD | LBD | 1 | II | None | Diffuse Neocortical | 3/3 | m | 62 | 10 | 1,2,3 |
93 | LBD | LBD | 1 | II | Sparse | Diffuse neocortical | 3/3 | m | 81 | 3 | 1,2 |