Fig. 1

High BTK expression in glioma tumors and vasculature. High BTK expression seen in grade IV gliomas with highest expression in glioblastoma tumors as noted by CGGA (left) and TCGA (right) plotted data (a). Representative low and high BTK expression staining in glioblastoma TMA. Low power magnification of BTK expression seen in tumor cells and high magnification is BTK expression of endothelium. Red arrows denote vascular staining (b). High BTK expression scoring predominately seen in both tissue and vascular staining, with table delineating sole versus dual BTK expression, ****p < 0.001 (c)