Fig. 5

Performance of an unsupervised pan-cancer dimension reduction (UMAP) with partial, brain tumour-restricted reference annotation (GSE90496) against bona fide integrated diagnoses (based on clinical, histological, copy number, and sequencing data). 798 routine diagnostic cases were analysed. Between 50 and 75’000 most variably methylated array probes were considered (TDMP = top differentially methylated probes)