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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Neuropathological changes associated with aberrant cerebrospinal fluid p-tau181 and Aβ42 in Alzheimer’s disease and other neurodegenerative diseases

Fig. 4

The association between CSF Aβ42 and Postmortem Amyloid Pathologic Scores in DLB/PDD and PSP/CBD. The study was performed in 21 patients with DLB/PDD (DLB, n = 11; PDD, n = 10) and 22 patients with PSP/CBD (PSP, n = 18; CBD n = 4). (A) A significant difference in CSF Aβ42 was observed between patients grouped according to postmortem Thal phase in DLB/PDD and tended to be lower in the highest Thal phase. (B) CSF Aβ42 was significantly lower in patients with frequent neuritic plaques in terms of the CERAD score at autopsy in DLB/PDD. (C, D) The difference in CSF Aβ42 was nonsignificant between patients grouped according to postmortem Thal phase or CERAD score in PSP/CBD. Decreased CSF Aβ42 below the cut-off was frequently observed in patients with a low Thal phase and CERAD score at autopsy. Note Circles, upward triangles, downward triangles, and squares represent data from patients with DLB, PDD, PSP, and CBD, respectively

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Acta Neuropathologica Communications

ISSN: 2051-5960

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