Fig. 6

CD206⁺ CAM accumulation in the mouse IA wall. a An increased number of CD206⁺ macrophages found in the ipsilateral hemisphere at Day5 post-aneurysm induction, especially around the IAs. This was significantly higher than the number of CD206⁺ cells found around the control vessels. b Quantification of accumulated CAMs confirmed the significant accumulation of these cells in the IA area (****P < 0.0001, N = 11 mice, n = 47 IAs/n = 23 contra arteries, Mann–Whitney U test). c CAMs (CD206⁺ cells) are positive for the lysosomal marker CD68. Scale bar: 100 μm. Scale bar: 100 μm. d Quantification of CD68⁺ cells in the IA area. (****P < 0.0001, N = 11 mice, n = 47 IAs/n = 23 contra arteries, Mann–Whitney U test). Statistical analysis was performed using Mann–Whitney U test; **P < 0.01, ***P < 0.001; NS, not significant. Further detailed information on statistics is provided in the Methods and Materials