Fig. 5

ltGLICO astrocytes are defined by regulators characteristic of reactive gliosis and ischemia. a UMAPs calculated on combined (weighted nearest neighbors) RNA and ATAC single cell data from 5 to 12 month ltGLICOs colored by genotype, age, clusters and cell type. b Expression density plots of pro-tumorigenic ligands (FGF1, FGF2, PDEFA and SPP1) in ltGLICOs. c Differential expression of transcription factors and enrichment of their associated motifs in cluster 10 astrocytes. d Motif plots of enriched regulators