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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Human adipose tissue-derived stem cell extracellular vesicles attenuate ocular hypertension-induced retinal ganglion cell damage by inhibiting microglia- TLR4/MAPK/NF-κB proinflammatory cascade signaling

Fig. 4

ADSC-EVs promote inner retinal thickness and retinal function in the OHT mice 2 weeks after injection. (A) In vivo experimental design. (a) Timeline of the study design when microbeads injection, intravitreal administration, and sample collection were carried out. (b) Representative fluorescence image of the anterior segment cross-Sect. 14 days after microbeads (arrow) injection. (c) Simultaneous IOP measurements in OHT eyes compared to the control group. ***p < 0.001 OHT + PBS eyes vs. control. ###p < 0.001 OHT + EVs eyes vs. control, ##p < 0.01 OHT + EVs eyes vs. control. (B) Representative fundus photographs, OCT images, retinal DAPI immunostaining and quantification of inner retinal thickness (n = 6–9, **p < 0.01, ***p < 0.001). RNFL (retinal nerve fiber layer), RGCL (retinal ganglion cell layer), IPL (inner plexiform layer), INL (inner nuclear layer). (C) F-VEP examination results in per group. (n = 6, ***p < 0.001)

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Acta Neuropathologica Communications

ISSN: 2051-5960

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