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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Human adipose tissue-derived stem cell extracellular vesicles attenuate ocular hypertension-induced retinal ganglion cell damage by inhibiting microglia- TLR4/MAPK/NF-κB proinflammatory cascade signaling

Fig. 1

Activation and proliferation of microglial cells in OHT mice. (A) Increased Iba-1 expression in microglia from OHT mice. (a) Iba-1 immunostaining (red) in the retina and optic nerve of intracameral injection of microsphere-induced OHT mice and PBS control. (b) Quantification of Iba-1+ microglia cells. (n = 3–4, **p < 0.01). (B) Increased CD68 and CCL2 expressions in microglia of OHT mice. (a, b) Immunostaining images of the retina from control and OHT mice at 7 days, demonstrated that activated microglia in the OHT group had a strong co-expression of CD68 or CCL2 with Iba-1 positive microglia (white arrows, n = 5, ***p < 0.001). (c, d) Representative immunostaining images of the optic nerve in control and OHT mice at 7 days, showed that activated microglia in the OHT group had a strong co-expression of CD68 or CCL2 with Iba-1 positive microglia (white arrows, n = 5, ***p < 0.001). GCL, ganglion cell layer; IPL, inner plexiform layer; INL, inner nuclear layer; ONL, outer nuclear layer

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Acta Neuropathologica Communications

ISSN: 2051-5960

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